Welcome to LookChem.com Sign In|Join Free

CAS

  • or

291773-90-5

Post Buying Request

291773-90-5 Suppliers

Recommended suppliersmore

  • Product
  • FOB Price
  • Min.Order
  • Supply Ability
  • Supplier
  • Contact Supplier

291773-90-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 291773-90-5 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,9,1,7,7 and 3 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 291773-90:
(8*2)+(7*9)+(6*1)+(5*7)+(4*7)+(3*3)+(2*9)+(1*0)=175
175 % 10 = 5
So 291773-90-5 is a valid CAS Registry Number.

291773-90-5Relevant articles and documents

Synthesis and pharmacological evaluation of new pyrazolidine-3,5-diones as AT1 angiotensin II receptor antagonists

Le Bourdonnec, Bertrand,Meulon, Emmanuelle,Yous, Sa?d,Goossens, Jean-Fran?ois,Houssin, Raymond,Hénichart, Jean-Pierre

, p. 2685 - 2697 (2007/10/03)

On the basis of the structure of the non-peptide receptor antagonist irbesartan, a new series of AT1 ligands was designed. In these compounds the central imidazolone nucleus of irbesartan was replaced by a pyrazolidine-3,5-dione structure. The key intermediate N-alkylpyrazolidine-3,5-diones were synthesized according to a new and general method. The most active compounds possess a spirocyclopentane ring at position 4, a linear butyl chain at position 1, and the [2'(5-tetrazolyl)biphenyl-4- yl]methyl or [2'-(benzoylaminosulfonyl)biphenyl-4-yl]methyl group at position 2. Affinity toward the AT1 and AT2 receptors was assessed by the ability of the compounds to competitively displace [3H]AII from its specific binding sites. The most active compounds, 28 and 48, displayed high affinity for the AT1 receptor, good selectivity AT1 versus AT2, and potent in vitro antagonist activity.

Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 291773-90-5