29174-66-1

Basic information

• Product Name: 3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID&
• Synonyms: 3-BROMO-1-BENZOTHIOPHENE-2-CARBOXYLIC ACID
• CAS NO: 29174-66-1
• Molecular Formula: C₉H₅BrO₂S
• Molecular Weight: 257.1
• Product Categories: Benzothiophenes;BenzothiophenesHeterocyclic Building Blocks;Building Blocks;Halogenated Heterocycles;Heterocyclic Building Blocks;Building Blocks;Chemical Synthesis;Halogenated Heterocycles;Heterocyclic Building Blocks
• Mol File: 29174-66-1.mol
• Article Data: 5

Chemical Properties

• Melting Point: 275-279 °C(lit.)
• Appearance: /
• CAS DataBase Reference: 3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID&(CAS DataBase Reference)
• NIST Chemistry Reference: 3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID&(29174-66-1)
• EPA Substance Registry System: 3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID&(29174-66-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22-43
• Safety Statements: 36/37
• WGK Germany: 3
• Hazardous Substances Data: 29174-66-1(Hazardous Substances Data)

Usage

Description

3-Bromobenzothiophene-2-carboxylic acid, with the molecular formula C9H5BrO2S, is a brominated derivative of benzothiophene carboxylic acid. It is a chemical compound known for its unique aromatic and heterocyclic structure, which makes it valuable for the production of various pharmaceuticals, agrochemicals, and materials. Its potential applications in medicinal chemistry are further highlighted by its antimicrobial, anticancer, and anti-inflammatory properties.

Uses

Used in Pharmaceutical Industry:
3-Bromobenzothiophene-2-carboxylic acid is used as a building block in organic synthesis for the development of novel molecules with potential therapeutic applications. Its unique structure allows for the creation of biologically active compounds, making it a valuable component in the production of pharmaceuticals.
Used in Agrochemical Industry:
In the agrochemical industry, 3-Bromobenzothiophene-2-carboxylic acid is utilized as a starting material for the synthesis of various agrochemicals. Its unique properties contribute to the development of effective compounds for agricultural applications.
Used in Materials Science:
3-Bromobenzothiophene-2-carboxylic acid is also used in materials science for the production of advanced materials. Its aromatic and heterocyclic structure provides unique properties that can be leveraged in the development of new materials with specific characteristics.
Used in Antimicrobial Applications:
3-Bromobenzothiophene-2-carboxylic acid is studied for its antimicrobial properties, making it a potential candidate for use in the development of new antimicrobial agents to combat resistant bacteria and other pathogens.
Used in Anticancer Applications:
3-BROMOBENZOTHIOPHENE-2-CARBOXYLIC ACID& has been studied for its anticancer properties, indicating its potential use in the development of novel anticancer drugs. Its unique structure may contribute to the inhibition of cancer cell growth and the modulation of oncological signaling pathways.
Used in Anti-inflammatory Applications:
3-Bromobenzothiophene-2-carboxylic acid's anti-inflammatory properties make it a promising candidate for the development of new anti-inflammatory drugs, which could be used to treat various inflammatory conditions and diseases.

Upstream product

• 6287-82-7 2,3-dibromobenzo[b]thiophene 
• 10135-00-9 3-bromobenzo[b]thiophene-2-carbaldehyde 
• 124-38-9 carbon dioxide 
• 637-44-5 phenylpropyolic acid 
• 95-15-8 Benzo[b]thiophene 
• 3541-37-5 benzothiophene-2-carboxaldehyde 
• 6314-28-9 benzo[b]thiophene-2-carboxylic acid 

Downstream Products

• 34128-30-8 methyl 3-bromobenzothiophene-2-carboxylate 
• 853328-52-6 3-bromo-benzo[b]thiophene-2-carboxylic acid phenylamide 
• 876620-11-0 3-bromo-benzo[b]thiophene-2-carboxylic acid 4-methoxy-benzylamide 
• 1155888-07-5 3-(2-fluorophenyl)-1H-[1]benzothieno[2,3-c]pyran-1-one 
• 1155888-02-0 3-phenyl-1H-[1]benzothieno[2,3-c]pyran-1-one 
• 1155888-05-3 3-(4-methoxyphenyl)-1H-[1]benzothieno[2,3-c]pyran-1-one 
• 1355943-30-4 N-benzyl-3-bromobenzo[b]thiophene-2-carboxamide 
• 1355943-32-6 3-bromo-N-[4-(trifluoromethyl)benzyl]-benzo[b]thiophene-2-carboxamide 
• 2387-23-7 1,3-Dicyclohexylurea 
• 1355943-34-8 3-bromo-N-(naphthalen-1-ylmethyl)-benzo[b]thiophene-2-carboxamide 
• 1355943-31-5 (3-bromo-N-(4-fluorobenzyl)benzo[b]thiophene-2-carboxamide) 
• 1355943-33-7 3-bromo-N-(2-phenylethyl)-benzo[b]thiophene-2-carboxamide 
• 1355943-35-9 3-bromo-N-(4-fluorobenzyl)-N-(prop-2-en-1-yl)-benzo[b]thiophene-2-carboxamide 
• 886-66-8 1,4-diphenyl-1,3-butadiyne 

Relevant articles and documents

Synthesis of new benzo[b]thieno fused ring systems via transition metal-mediated cyclisations

The compact synthesis of a new ring fused benzo[b]thieno derivative with an embedded nine-membered ring system via ring closing metathesis methodology is described. The preparation of the novel 11H-benzo[b]thieno[2,3-c]pyrrolo[2,3-a] indol-11-one via palladium-mediated oxidative cyclisation of benzo[b]thien-2-oyl indole derivatives is also reported.

Synthesis of novel chiral thiophene-, benzothiophene- and benzofuran-oxazoline ligands and their use in the enantioselective Pd-catalyzed allylation

Novel thiophene, benzothiophene and benzofuran-oxazoline ligands 6-11 containing a diphenylphosphino group at different positions of the heterocyclic skeleton have been prepared and used in the enantioselective allylation. The advantage of these new ligands is their easy accessibility and their high reactivity. The best results were obtained with ligand 9 to give the product 13 in 97.0% ee with 92% yield in 2 hours at 0°C.

An Improved Synthesis of Thiophene-2,3-dicarboxylic Acid by Sequential Carboxylation

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