289893-25-0

Basic information

• Product Name: (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol
• Synonyms: (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol;arimoclomol;Amrioclomol;Pefcalcitol
• CAS NO: 289893-25-0
• Molecular Formula: C₁₄H₂₀ClN₃O₃
• Molecular Weight: 313.7799
• Mol File: 289893-25-0.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 539.2°Cat760mmHg
• Flash Point: 279.9°C
• Appearance: /
• Density: 1.32g/cm³
• Vapor Pressure: 1.85E-12mmHg at 25°C
• Refractive Index: 1.593
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 14.03±0.20(Predicted)
• Stability: Hygroscopic
• CAS DataBase Reference: (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol(289893-25-0)
• EPA Substance Registry System: (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol(289893-25-0)

Safety Data

• Hazardous Substances Data: 289893-25-0(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol is used as a potential therapeutic agent for the treatment of motor neuron degenerative diseases. Its action as a co-inducer of heat shock proteins (HSP) through heat shock factor 1 (HSF1) in cells undergoing cellular stress provides a promising avenue for therapeutic intervention in such conditions.
Used in Treatment of Liposomal Storage Disorders:
In the field of genetic medicine, (2R)-1-[[chloro-(1-oxidopyridin-5-yl)methylidene]amino]oxy-3-(1-piperidyl)propan-2-ol demonstrates potential as a treatment for liposomal storage disorders, such as Niemann-Pick disease type C. Its ability to modulate cellular processes and interact with cellular components may contribute to its therapeutic effects in these disorders.

InChI:InChI=1/C14H20ClN3O3/c15-14(12-5-4-8-18(20)9-12)16-21-11-13(19)10-17-6-2-1-3-7-17/h4-5,8-9,13,19H,1-3,6-7,10-11H2/t13-/m1/s1

Relevant articles and documents

THERAPEUTIC AGENT FOR CHORIORETINAL DEGENERATIVE DISEASES COMPRISING PYRIDINE-3-CARBALDEHYDE O-(PIPERIDIN-1-YL-PROPYL)-OXIME DERIVATIVE AS ACTIVE INGREDIENT

Provided is a novel prophylactic or therapeutic agent for a chorioretinal degenerative disease. The compound of formula (1) or its salt has inhibitory effects on photoreceptor cell death or visual cell death in a mouse model of light damage. Therefore, the compound or its salt is useful as a prophylactic or therapeutic agent for a chorioretinal degenerative disease such as age-related macular degeneration, retinitis pigmentosa. In the formula(1), A is a group (p1), (p2) or (p3); R1 is H, alkyl, aralkyl or OH or its ester; R2 is H or alkyl; R3 is halogen, H, alkyl or OH or its ester; R4 is halogen, H, OH, alkoxy, amino, alkylamino or cycloalkylamino, R3 and R4 may be joined to each other through N to form an unsaturated [1,2,4]oxadiazine ring; R5 is H, alkyl or cycloalkyl; m is 0 or 1; and n is 0 or 1.