289483-79-0

Basic information

• Product Name: 4-methyl-7-nitro-1H-indole-2-carboxylic acid
• Synonyms: 4-methyl-7-nitro-1H-indole-2-carboxylic acid
• CAS NO: 289483-79-0
• Molecular Formula: C10H8N2O4
• Molecular Weight: 220.18152
• Mol File: 289483-79-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 532.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.544±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.12±0.30(Predicted)
• CAS DataBase Reference: 4-methyl-7-nitro-1H-indole-2-carboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-methyl-7-nitro-1H-indole-2-carboxylic acid(289483-79-0)
• EPA Substance Registry System: 4-methyl-7-nitro-1H-indole-2-carboxylic acid(289483-79-0)

Safety Data

• Hazardous Substances Data: 289483-79-0(Hazardous Substances Data)

Usage

Description

4-methyl-7-nitro-1H-indole-2-carboxylic acid is a chemical compound with the molecular formula C11H8N2O4. It is an indole derivative that features a nitro group and a carboxylic acid functional group, making it a versatile building block in organic chemistry and a potential candidate for various applications in pharmaceuticals, agrochemicals, and research.

Uses

Used in Pharmaceutical and Agrochemical Synthesis:
4-methyl-7-nitro-1H-indole-2-carboxylic acid is used as a key intermediate in the synthesis of pharmaceuticals and agrochemicals due to its unique structural features and reactivity, contributing to the development of new drugs and pesticides.
Used as a Fluorescent Marker in Research:
In biological and medical research, 4-methyl-7-nitro-1H-indole-2-carboxylic acid serves as a fluorescent marker, enabling the tracking and visualization of cellular processes and molecular interactions, thus aiding in the advancement of scientific understanding.
Used in Anti-inflammatory and Anti-cancer Applications:
4-methyl-7-nitro-1H-indole-2-carboxylic acid has been studied for its potential as an anti-inflammatory and anti-cancer agent, with its unique chemical properties possibly offering therapeutic benefits in the treatment of inflammation and cancer.
Safety Precautions:
It is crucial to handle 4-methyl-7-nitro-1H-indole-2-carboxylic acid with care, as it may pose health risks if ingested, inhaled, or comes into contact with the skin, necessitating proper safety measures during its use and disposal.

Upstream product

• 61149-52-8 4-methyl-7-nitro-indole-2-carboxylic acid ethyl ester 

Relevant articles and documents

Integrin expression inhibitors

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, —CH═CH— or —(CR4bR5b)mb— (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or —CO—NH—; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.

INTEGRIN EXPRESSION INHIBITORS

The present invention provides an integrin expression inhibitor, and an agent for treating arterial sclerosis, psoriasis, cancer, retinal angiogenesis, diabetic retinopathy or inflammatory diseases, an anticoagulant, or a cancer metastasis suppressor on the basis of an integrin inhibitory action. Namely, it provides an integrin expression inhibitor comprising, as an active ingredient, a sulfonamide compound represented by the following formula (I), a pharmacologically acceptable salt thereof or a hydrate of them. In the formula, B means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated; K means a single bond, -CH=CH- or - (CR4bR5b)mb- (wherein R4b and R5b are the same as or different from each other and each means hydrogen atom or a C1-C4 alkyl group; and mb means an integer of 1 or 2); R1 means hydrogen atom or a C1-C6 alkyl group; Z means a single bond or -CO-NH-; and R means a C6-C10 aryl ring or 6- to 10-membered heteroaryl ring which may have a substituent and in which a part of the ring may be saturated, respectively.