288-14-2 Usage
Description
Isoxazole is a five-membered heterocyclic compound with various pharmacological actions, characterized by a monocyclic structure consisting of three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is found in some natural products and serves as the basis for a number of drugs. Isoxazoles are largely applied in pharmaceuticals and therapeutics, including insecticidal, antibacterial, antibiotic, antitumor, antifungal, antituberculosis, anticancer, and ulcerogenic properties. They also have effects on reducing blood glucose, eliminating pain, resisting inflammation, killing harmful bacteria, and controlling and reducing the risk of HIV.
Uses
Used in Pharmaceutical Industry:
Isoxazole is used as a key component in the development of various drugs, such as the COX-2 inhibitor valdecoxib and anti-inflammatory drugs, due to its diverse pharmacological actions and potential therapeutic applications.
Used in Insecticide Industry:
Isoxazole is used as a natural insecticide, acting as an inhibitor of acetylcholinesterase (AChE) and binding to the Sxcantiporter, which helps in controlling and reducing the risk of insect infestations.
Used in Antibacterial and Antifungal Applications:
Isoxazole is used as an antibacterial and antifungal agent, contributing to the development of treatments for bacterial and fungal infections.
Used in Antituberculosis and Anticancer Applications:
Isoxazole is used as an antituberculosis and anticancer agent, playing a role in the development of drugs for the treatment of tuberculosis and various types of cancer.
Used in Anti-inflammatory and Analgesic Applications:
Isoxazole is used as an anti-inflammatory and analgesic agent, helping in reducing inflammation and eliminating pain.
Used in Antiviral Applications:
Isoxazole is used in the development of antiviral drugs, particularly for controlling and reducing the risk of HIV.
Used in Beta-lactamase-resistant Antibiotics:
Isoxazole is used as a component in some beta-lactamase-resistant antibiotics, such as cloxacillin, dicloxacillin, and flucloxacillin, to enhance their effectiveness against bacterial infections.
Chemical Properties:
Isoxazole is a colorless liquid with a wide range of applications in various industries.
References
https://en.wikipedia.org/wiki/Isoxazole
http://www.ijpcbs.com/files/volume3-2-2013/15.pdf
Hazard
Narcotic and psychomimetic effects.
Check Digit Verification of cas no
The CAS Registry Mumber 288-14-2 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,8 and 8 respectively; the second part has 2 digits, 1 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 288-14:
(5*2)+(4*8)+(3*8)+(2*1)+(1*4)=72
72 % 10 = 2
So 288-14-2 is a valid CAS Registry Number.
InChI:InChI=1/C3H3NO/c1-2-4-5-3-1/h1-3H
288-14-2Relevant articles and documents
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Pouchan et al.
, p. 39,40,42,43 (1976)
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Photocycloaddition of aromatic and aliphatic aldehydes to isoxazoles: Cycloaddition reactivity and stability studies
Griesbeck, Axel G.,Franke, Marco,Neudoerfl, Joerg,Kotaka, Hidehiro
experimental part, p. 127 - 134 (2011/05/16)
The first photocycloadditions of aromatic and aliphatic aldehydes to methylated isoxazoles are reported. The reactions lead solely to the exo-adducts with high regio- and diastereoselectivities. Ring methylation of the isoxazole substrates is crucial for high conversions and product stability. The 6-arylated bicyclic oxetanes 9a-9c were characterized by X-ray structure analyses and showed the highest thermal stabilities. All oxetanes formed from isoxazoles were highly acid-sensitive and also thermally unstable. Cleavage to the original substrates is dominant and the isoxazole derived oxetanes show type T photochromism.
NOVEL FLORFENICOL-TYPE ANTIBIOTICS
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, (2008/06/13)
The present invention relates to novel florfenicol compounds having the chemical structure: wherein the compounds are useful for the treatment and/or prevention of bacterial infections in a broad range of patients such as, without limitation, birds, fish, shellfish and mammals
