28540-48-9

Basic information

• Product Name: Benzo[b]thiophene, 2-(2-phenylethyl)-
• CAS NO: 28540-48-9
• Molecular Formula: C16H14S
• Molecular Weight: 238.353
• Mol File: 28540-48-9.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: Benzo[b]thiophene, 2-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzo[b]thiophene, 2-(2-phenylethyl)-(28540-48-9)
• EPA Substance Registry System: Benzo[b]thiophene, 2-(2-phenylethyl)-(28540-48-9)

Safety Data

• Hazardous Substances Data: 28540-48-9(Hazardous Substances Data)

Upstream product

• 765292-75-9 2-[2'-(tert-butyldimethylsilylsulfanyl)phenyl]-1.3-dithiane 
• 765292-71-5 1-[2'-(tert-butylsulfanyl)phenyl]-4-phenylbutan-2-one 
• 65924-65-4 2-(tert-butylthio)benzaldehyde 
• 552-89-6 2-nitro-benzaldehyde 
• 147-93-3 Thiosalicylic acid 
• 35531-58-9 2-(2-nitrophenyl)-1,3-dithiane 
• 55164-16-4 2,2'-dithiodibenzaldehyde 
• 4521-31-7 o-hydroxymethyl thiophenol 
• 53165-22-3 2-(2'-aminophenyl)-1,3-dithiane 
• 765292-73-7 C₂₀H₂₂S₆ 
• 765292-68-0 2-[2'-(tert-butylsulfanyl)phenyl]-1,3-dithiane 
• 765292-74-8 2-(2'-mercaptophenyl)-1,3-dithiane 

Downstream Products

• 28684-74-4 2-[(E)-2-phenylvinyl]-1-benzothiophene 
• 205-43-6 Benzo[b]naphtho[1,2-d]thiophene 

Relevant articles and documents

Titanium reagents for the synthesis of 2-substituted benzo[b]thiophenes on the solid phase

Titanium(IV) benzylidenes (Schrock carbenes) bearing a masked sulfur nucleophile in the ortho position were generated from thioacetals with use of low-valent titanocene complex Cp2Ti[P(OEt)3]2 and alkylidenated Merrifield resin-bound esters to give enol ethers. Treatment of the resin-bound enol ethers with a 5:5:90 mixture of TFA, TFAA, and dichloromethane led to cleavage from resin, removal of the tert- butyldimethylsilyl (TBDMS) protecting group, and concomitant cyclization to complete the traceless solid-phase synthesis (SPS) of benzothiophenes. Switching the nature of the linker from acid-stable to acid-sensitive ensured good purity.