28447-91-8Relevant articles and documents
Pulse radiolysis-laser flash photolysis study of xanthene in 1,2-dichloroethane/carbon tetrachloride
Sumiyoshi, Takashi,Wu, Feng,Shindo, Toshihiko,Ueta, Syohei,Sawamura, Sadashi
, p. 1167 - 1168 (1997)
The photochemistry of 9-xanthenyl radicals produced by pulse radiolysis of xanthene in 1,2-dichloroethane (1,2-DCE) and CCl4 was studied by means of successive laser flash photolysis. Photobleaching due to chlorine atom transfer from solvents to the excited 9-xanthenyl radical was observed with quantum yields of 0.04 and 0.29 in 1,2-DCE and CCl4, respectively.
Correlating ionic liquid solvent effects with solvent parameters for a reaction that proceeds through a xanthylium intermediate
Gilbert, Alyssa,Bucher, G?tz,Haines, Ronald S.,Harper, Jason B.
supporting information, p. 9336 - 9342 (2019/11/13)
A unimolecular nucleophilic substitution reaction that proceeds through a xanthylium carbocation was studied in seven ionic liquid solvents. It was found that the general trend in the rate constant with changing proportion of ionic liquid in the reaction mixture was different to that seen for other unimolecular processes, with the rate constant increasing as more ionic liquid was added to the reaction mixture. A significant correlation was found between the natural logarithm of the rate constant and a combination of the Kamlet-Taft solvent parameters. This relationship indicated that the principal interaction involved hydrogen bonding between the ionic liquid and some species along the reaction coordinate. Further, this correlation enables prediction of the effects that other ionic liquids will have on this, and other, reactions that proceed through a similar intermediate.
Steric structure–activity relationship of cyproheptadine derivatives as inhibitors of histone methyltransferase Set7/9
Fujiwara, Takashi,Ohira, Kasumi,Urushibara, Ko,Ito, Akihiro,Yoshida, Minoru,Kanai, Misae,Tanatani, Aya,Kagechika, Hiroyuki,Hirano, Tomoya
, p. 4318 - 4323 (2016/08/23)
Set7/9 is a histone lysine methyltransferase, but it is also thought to be involved in a wide variety of pathophysiological functions. We previously identified cyproheptadine, which has a characteristic butterfly-like molecular conformation with bent tricyclic dibenzosuberene and chair-form N-methylpiperidine moieties, as a Set7/9 inhibitor. In this work, we synthesized several derivatives in order to examine the steric structure–inhibitory activity relationship. We found that even a small change of molecular shape due to reduction or replacement of the 10,11-olefinic bond of the tricyclic ring generally resulted in a drastic decrease of the inhibitory activity. Our results should be useful not only for development of more potent and selective inhibitors, but also for the construction of novel inhibitor scaffolds.