2814-20-2 Usage
Description
2-Isopropyl-6-methyl-4-pyrimidinol is a pyrimidine compound that serves as a significant intermediate in the synthesis of various benzophenone derivatives, which possess antifungal and antibacterial properties. It is also recognized as a major metabolite of the pesticide diazinon and has been identified in the general population exposed to organophosphorus compounds, such as insecticides, flame retardants, and plasticizers, as well as moth repellents used in Japanese households.
Uses
Used in Pharmaceutical Industry:
2-Isopropyl-6-methyl-4-pyrimidinol is used as an intermediate for the synthesis of benzophenone derivatives, which exhibit antifungal and antibacterial activities. These derivatives are essential in the development of pharmaceutical products aimed at treating various infections and diseases caused by fungi and bacteria.
Used in Pesticide Synthesis:
In the agricultural industry, 2-Isopropyl-6-methyl-4-pyrimidinol is utilized as a key intermediate in the synthesis of Diazinon (D416880) and Diazoxon (D416890), which are organophosphate insecticides. These insecticides play a crucial role in controlling pests and protecting crops from damage, thereby ensuring food security and crop yield.
Used in Environmental and Analytical Chemistry:
2-Isopropyl-6-methyl-4-pyrimidinol has been identified as a urinary metabolite in the general population exposed to organophosphorus compounds, such as insecticides, flame retardants, and plasticizers. This makes it an important biomarker for assessing human exposure to these compounds and understanding their potential health impacts. Additionally, the photocatalytic oxidation of 2-isopropyl-6-methyl-4-pyrimidinol has been reported, which could have implications for environmental remediation and the development of new analytical methods for detecting and monitoring the presence of organophosphorus compounds in the environment.
Check Digit Verification of cas no
The CAS Registry Mumber 2814-20-2 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,8,1 and 4 respectively; the second part has 2 digits, 2 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 2814-20:
(6*2)+(5*8)+(4*1)+(3*4)+(2*2)+(1*0)=72
72 % 10 = 2
So 2814-20-2 is a valid CAS Registry Number.
InChI:InChI=1/C8H12N2O/c1-5(2)8-9-6(3)4-7(11)10-8/h4-5H,1-3H3,(H,9,10,11)
2814-20-2Relevant articles and documents
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Snyder,Foster
, p. 118,121 (1954)
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SUPPORTED MOLYBDENUM PEROXO COMPLEXES FOR TRANSFORMING ORGANO PHOSPHATE NEUROTOXINS TO A VALUE-ADDED, COMMODITY PHOSPHORUS CHEMICAL
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Paragraph 0022, (2018/10/21)
The invention relates to degradation of organophosphate neurotoxins with molybdenum complexes. In particular, the degradation of phosphate ester neurotoxins can be performed with molybdenum peroxo complexes resulting in recoverable phosphorus-containing compounds.
Influence of Natural Dissolved Organic Matter, Temperature, and Mixing on the Abiotic Hydrolysis of Triazine and Organophosphate Pesticides
Noblet, James A.,Smith, Lynda A.,Suffet
, p. 3685 - 3693 (2007/10/03)
Abiotic hydrolysis of simazine, atrazine, diazinon, methylparathion, and chlorpyrifos was studied in three different natural waters and buffered Milli-Q water. The triazines showed no detectable decrease in concentration in any of the waters over 43 days at pH 8.0 and 40 °C. The rates of hydrolysis for diazinon and methylparathion were statistically similar in all waters tested. Chlorpyrifos exhibited a ～32% decrease in hydrolysis rate in the presence of a high concentration of dissolved organic matter (DOM) (34.5 mg/L dissolved organic carbon). The activation energies are larger, and thus the predicted hydrolysis rates are significantly slower than those previously reported. The effect of continuous vigorous mixing on hydrolysis rates was investigated and found to have only a minor effect. The results suggest that uncatalyzed abiotic hydrolysis is very slow for these compounds at the temperatures and pH's typical of most natural waters and affirm the need for a greater understanding of the relative influence of DOM, catalysis, and biodegradation on the fate of organophosphate and triazine pesticides.
