281211-09-4 Usage
General Description
N-(tert-Butyl)-3,6,7-trichloroquinoxalin-2-amine is a chemical compound that consists of a trichloroquinoxaline core with a tert-butyl group and an amine group attached to it. It is primarily used as a building block in organic synthesis and pharmaceutical research. N-(tert-Butyl)-3,6,7-trichloroquinoxalin-2-amine has potential applications in the development of drugs and agrochemicals due to its unique structural features. It may also have biological activities that make it suitable for further investigation in medicinal chemistry and pharmacology. Additionally, the tert-butyl group provides steric hindrance, which can impact its reactivity and pharmacokinetic properties. Overall, N-(tert-Butyl)-3,6,7-trichloroquinoxalin-2-amine is a versatile and valuable compound with promising potential for various scientific and industrial applications.
Check Digit Verification of cas no
The CAS Registry Mumber 281211-09-4 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,8,1,2,1 and 1 respectively; the second part has 2 digits, 0 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 281211-09:
(8*2)+(7*8)+(6*1)+(5*2)+(4*1)+(3*1)+(2*0)+(1*9)=104
104 % 10 = 4
So 281211-09-4 is a valid CAS Registry Number.
InChI:InChI=1/C12H12Cl3N3/c1-12(2,3)18-11-10(15)16-8-4-6(13)7(14)5-9(8)17-11/h4-5H,1-3H3,(H,17,18)
281211-09-4Relevant articles and documents
Small molecule ago-allosteric modulators of the human glucagon-like peptide-1 (hGLP-1) receptor
Teng, Min,Johnson, Michael D.,Thomas, Christine,Kiel, Dan,Lakis, James N.,Kercher, Tim,Aytes, Shelley,Kostrowicki, Jarek,Bhumralkar, Dilip,Truesdale, Larry,May, John,Sidelman, Ulla,Kodra, Janos T.,Jorgensen, Anker Steen,Olesen, Preben Houlberg,de Jong, Johannes Cornelis,Madsen, Peter,Behrens, Carsten,Pettersson, Ingrid,Knudsen, Lotte Bjerre,Holst, Jens J.,Lau, Jesper
, p. 5472 - 5478 (2008/09/18)
Following our previous publication describing the biological profiles, we herein describe the structure-activity relationships of a core set of quinoxalines as the hGLP-1 receptor agonists. The most potent and efficacious compounds are 6,7-dichloroquinoxalines bearing an alkyl sulfonyl group at the C-2 position and a secondary alkyl amino group at the C-3 position. These findings serve as a valuable starting point for the discovery of more drug-like small molecule agonists for the hGLP-1 receptor.
