28005-76-7

Basic information

• Product Name: 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol
• Synonyms: 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol
• CAS NO: 28005-76-7
• Molecular Formula: C₁₁H₁₇NO₃
• Molecular Weight: 211.26
• Mol File: 28005-76-7.mol
• Article Data: 12

Chemical Properties

• Boiling Point: 350.8°Cat760mmHg
• Flash Point: 165.9°C
• Appearance: /
• Density: 1.177g/cm³
• PKA: 14.31±0.10(Predicted)
• CAS DataBase Reference: 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol(28005-76-7)
• EPA Substance Registry System: 2-[2-hydroxyethyl-(2-methoxyphenyl)amino]ethanol(28005-76-7)

Safety Data

• Hazardous Substances Data: 28005-76-7(Hazardous Substances Data)

Usage

2. Chemical structure

consists of a hydroxyethylamine group and a methoxyphenylamine group attached to an ethanol molecule
3. Common usage: pharmaceutical industry as a precursor in the synthesis of various drugs, particularly those with anti-inflammatory and analgesic properties
4. Applications: formulation of cosmetics and personal care products as a skin-conditioning agent
5. Potential use: in organic chemistry as a reagent for the synthesis of other complex molecules
6. Further research required: to fully understand the properties and potential applications of the compound.

Upstream product

• 594-01-4 1-chloroethanol 
• 90-04-0 2-methoxy-phenylamine 
• 584-08-7 potassium carbonate 
• 869634-78-6 [(methoxycarbonylmethyl)(2-methoxyphenyl)amino]-acetic acid methyl ester 
• 98269-29-5 ethyl-2-amino-(N,N-diacetate)anisole 
• 107-07-3 2-chloro-ethanol 
• 75-21-8 oxirane 

Downstream Products

• 98269-22-8 13-(2-methoxyphenyl)-1,4,7,10-tetraoxa-13-cyclopentadecane 
• 2108567-79-7 cis-N-(2-(4-(2-methoxyphenyl)piperazin-1-yl)cyclohexyl)benzenesulfonamide 
• 1268821-38-0 4'-(2-methoxyphenyl)spiro[indoline-1,1'-piperazin]-1-ium chloride 
• 497145-46-7 4-(6-{2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamino}-1,3-dioxo-1H,3H-benzo[de]isoquinolin-2-ylmethyl)-benzoic acid tert-butyl ester 
• 497145-43-4 2-[3-methoxy-4-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-yl)-phenyl]-ethylamine 
• 216852-10-7 N-(4-formyl-2-methoxyphenyl)aza[15]crown-5 ether 
• 113342-99-7 2-[(2-hydroxyethyl)(2-methoxy-4-nitrophenyl)amino]ethanol 
• 98269-26-2 N-(2-methoxyphenyl)monoaza-18-crown-6 
• 1207-00-7 bis-N,N-(2-chloroethyl)-2-methoxyaniline 

Relevant articles and documents

A novel optically based chemosensor for the detection of blood Na+

The azo dye based chemosensor 2 displays extremely good sensitivity and selectivity for Na+ over other physiologically important alkali and alkali earth metal ions in the 0.3-1.0×10-4 M concentration range as well as being pH independent above pH 3.9. This sensitivity coincides with the Na+ concentration range found in blood. The sensor exhibits almost 110 nm hypsochromic shift in the absorption spectrum upon Na+ detection, with a strong colour change from red to yellow in aqueous solution which is clearly visible to the naked eye even at low concentrations.

Preparation method of Na molecular fluorescent intermediate and preparation method of Na molecular fluorescent sensor

The invention provides a preparation method of a Na molecular fluorescent intermediate and a preparation method of a Na molecular fluorescent sensor. The Na molecular fluorescent intermediatehas a structure as shown in a formula I. The preparation method of the Na molecular fluorescent intermediate comprises the following steps: S1, carrying out a substitution reaction on o-anisidineand alpha-methyl haloacetate to obtain a compound 2; S2, carrying out a reduction reaction on the compound 2 to obtain a compound 3; S3, carrying out a hydroxyl substitution on the compound 4 by adopting toluene sulfonyl chloride to obtain a compound 5, wherein the compound 4 has a structural formula as the follows; S4, carrying out a cyclization reaction on the compound 3 and the compound 5 to obtain a compound 6; S5, carrying out a formylation reaction on the compound 6 to obtain a compound 7; S6, carrying out a henry reaction on the compound 7 with nitromethane to obtain a compound 8; and S7, carrying out nitroso reduction reaction on the compound 8 to obtain the Na molecular fluorescent intermediate. The method is beneficial to improving the yield of the Na molecular fluorescentintermediate.

Sodium-Selective Fluoroionophore-Based Optodes for Seawater Salinity Measurement

A new fluorescent sensor for Na+ is presented. The sensor relies on a Na+ selective fluoroionophore based on a bright red-emitting BODIPY chromophore. The fluorescence of the fluoroionophore is enhanced upon binding of Na+-ions to the highly selective aza-crown ether receptor due to reduction of the photoinduced electron transfer (PET) quenching. Solid state sensing materials were prepared by physically embedding the fluoroionophore into water-swellable biocompatible polymer matrices (polyurethane hydrogels), thus enabling continuous measurements of aqueous samples. Despite the simple design, the sensor showed no leaching of the indicator and featured fast and reversible response. Among different polyurethane hydrogels investigated, the hydrogel D1 featuring the highest water uptake was found to be the most suitable due to the highest dynamics between "off" and "on" states. Due to little or no cross sensitivity to other ions (e.g., Mg2+, Ca2+, K+) and its insensitivity to potential changes in pH, this sensor is promising for use in clinical diagnostics and for biological and marine applications. Fiber-optic sensors based on referenced read-out with a compact phase fluorimeter were prepared. To demonstrate their practical applicability, the sensors were used to determine the salinity in the seawater and brackish water of the Baltic Sea.