278788-66-2

Basic information

• Product Name: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
• Synonyms: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER;(R)-4-N-BOC-2-HYDROXYMETHYL-PIPERAZINE;(R)-1-Boc-3-hydroxymethyl-piperazine;(R)-tert-Butyl 3-(hydroxymethyl)piperazine-1-carboxylate;H57159;(R)-4-Boc-2-hydroxymethyl-piperazine;1-Piperazinecarboxylic acid, 3-(hydroxymethyl)-, 1,1-dimethylethyl ester, (3R)-;(R)-1-Boc-3-(Hydroxymethyl)piperazine ,98%
• CAS NO: 278788-66-2
• Molecular Formula: C₁₀H₂₀N₂O₃
• Molecular Weight: 216.28
• Product Categories: pharmacetical;Piperaizine
• Mol File: 278788-66-2.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 322.9 °C at 760 mmHg
• Flash Point: 149.1 °C
• Appearance: /
• Density: 1.085 g/cm³
• Vapor Pressure: 2.15E-05mmHg at 25°C
• Refractive Index: 1.477
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly)
• PKA: 14.97±0.10(Predicted)
• CAS DataBase Reference: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)
• EPA Substance Registry System: (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER(278788-66-2)

Safety Data

• Hazard Codes: Xi
• Statements: 41-52
• Safety Statements: 26-39
• Hazardous Substances Data: 278788-66-2(Hazardous Substances Data)

Usage

Description

(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER, also known as (R)-1-Boc-3-hydroxymethylpiperazine, is an organic compound that serves as a crucial building block in the synthesis of various pharmaceutical agents. It is characterized by its unique molecular structure, which includes a hydroxymethyl group and a tert-butyl ester group attached to a piperazine-1-carboxylic acid framework. This versatile compound plays a significant role in the development of innovative therapeutics for a range of medical conditions.

Uses

Used in Pharmaceutical Industry:
(R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is used as a building block for the preparation of PI3K inhibitors for rheumatoid arthritis treatment. Its incorporation into these inhibitors allows for the development of targeted therapies that can effectively manage the symptoms and progression of rheumatoid arthritis.
Used in Antimalarial Agents:
In the field of antimalarial drug development, (R)-3-HYDROXYMETHYL-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER is utilized in the synthesis of benzoxaborole derivatives. These derivatives exhibit potent antimalarial activity, offering a promising avenue for the creation of new treatments to combat malaria.
Used in Anti-tuberculosis Agents:
Similarly, this compound is employed in the production of benzoxaborole derivatives that possess anti-tuberculosis properties. The development of these agents is crucial in the ongoing fight against tuberculosis, a disease that continues to affect millions of people worldwide.

InChI:InChI=1/C10H20N2O3/c1-10(2,3)15-9(14)12-5-4-11-8(6-12)7-13/h8,11,13H,4-7H2,1-3H3/t8-/m1/s1

Upstream product

• 173774-50-0 N-Boc-piperazine-2-amidoanhydride 

Downstream Products

• 943238-14-0 1,1-dimethylethyl (3R)-4-[3-fluoro-5-(trifluoromethyl)-2-pyridinyl]-3-(hydroxymethyl)-1-piperazinecarboxylate 
• 1147422-39-6 (R)-4-(2-chloroacetyl)-3-(hydroxymethyl)piperazine-1-carboxylic acid tert-butyl ester 
• 1147422-40-9 (R)-4-oxohexahydropyrazino[2,1-c][1,4]oxazine-8-carboxylic acid tert-butyl ester 
• 930783-26-9 (R)-hexahydropyrazino[2,1-c][1,4]oxazin-4-one 
• 1147421-61-1 (R)-8-((2-(5-fluoro-1H-indol-4-yl)-4-morpholinothieno[3,2-d]pyrimidin-6-yl)methyl)octahydropyrazino[2,1-c][1,4]oxazine 
• 1147422-41-0 (R)-8-(2-chloro-4-morpholin-4-ylthieno[3,2-d]pyrimidin-6-ylmethyl)octahydropyrazino[2,1-c][1,4]oxazine 
• 508241-14-3 (R)-octahydropiperazine[2,1-c][1,4]oxazine 
• 1426073-09-7 (3R,9aS)-3-(3-cyano-4-fluoro-2-methyl-phenyl)-3-hydroxy-hexahydro-pyrazino[2,1-c][ 1,4]oxazine-8-carboxylic acid tert-butyl ester 
• 1443737-21-0 tert-butyl (3R)-4-[2-(4-cyano-3-methoxyphenyl)-2-hydroxyethyl]-3-(hydroxymethyl)piperazine-1-carboxylate 
• 660862-82-8 (R)-2-phenoxymethylpiperazine 
• 1589081-70-8 (R)-3-phenoxymethylpiperazine-1-carboxylic acid tert-butyl ester 
• 1589081-79-7 (R)-2-(2-fluorophenoxymethyl)piperazine 
• 1589081-71-9 (R)-3-(2-fluorophenoxymethyl)piperazine-1-carboxylic acid tert-butyl ester 

Relevant articles and documents

FARNESYL PROTEIN TRANSFERASE INHIBITORS

Disclosed are compounds of formula (1.0), wherein R represents a cyclic moiety to which is bound an imodazolylalkyl group; R represents a carbamate, urea, amide or sulfonamide group; and the remaining substituents are as defined herein. Also disclosed is a method of treating cancer and a method of inhibiting farnesyl protein transferase using the disclosed compounds.