27746-03-8

Basic information

• Product Name: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID
• Synonyms: 4-Chloropyrrole-2-carboxylicacid
• CAS NO: 27746-03-8
• Molecular Formula: C₅H₄ClNO₂
• Molecular Weight: 145.54
• Mol File: 27746-03-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 361.9 °C at 760 mmHg
• Flash Point: 172.7 °C
• Appearance: /
• Density: 1.577 g/cm³
• Vapor Pressure: 7.17E-06mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID(27746-03-8)
• EPA Substance Registry System: 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID(27746-03-8)

Safety Data

• Hazardous Substances Data: 27746-03-8(Hazardous Substances Data)

Usage

Description

4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID is a chlorinated derivative of pyrrole-2-carboxylic acid with the molecular formula C5H4ClNO2. It is a white solid at room temperature, soluble in organic solvents, and is commonly used in the synthesis of pharmaceuticals and agrochemicals. This chemical compound has been studied for its potential biological activity and pharmacological applications, making it a significant component in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID is used as an intermediate in the synthesis of various pharmaceuticals for its potential biological activity and pharmacological applications. It plays a crucial role in the development of new drugs and therapeutic agents.
Used in Agrochemical Industry:
In the agrochemical industry, 4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID is utilized in the production of agrochemicals, contributing to the development of effective and safe products for agricultural applications.
Used in Dye and Pigment Manufacturing:
4-CHLORO-1H-PYRROLE-2-CARBOXYLIC ACID is used as a key component in the manufacture of dyes and pigments, enabling the creation of a wide range of colors and shades for various applications.
Used in Organic Compound Synthesis:
This chemical compound is also used in the synthesis of other organic compounds, further expanding its applications across different industries and research areas.

InChI:InChI=1/C5H4ClNO2/c6-3-1-4(5(8)9)7-2-3/h1-2,7H,(H,8,9)

Upstream product

• 35302-72-8 pyrrol-2-yl trichloromethyl ketone 
• 72652-31-4 2,2,2-trichloro-1-(4-chloro-1H-pyrrol-2-yl)ethan-1-one 

Downstream Products

• 915229-94-6 (S)-3-[5-(4-chloro-1H-pyrrol-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidine-1-carboxylic acid tert-butyl ester 
• 915229-95-7 (S)-3-[5-(4-chloro-1H-pyrrol-2-yl)-[1,2,4]oxadiazol-3-yl]-piperidine hydrochloride 
• 869634-03-7 4-chloro-1H-pyrrole-2-carbohydrazide 
• 959771-58-5 4-chloro-N-[3-(3-cyano-4-fluorophenyl)prop-2-yn-1-yl]-N-(2,4-dimethoxybenzyl)-1H-pyrrole-2-carboxamide 
• 959771-66-5 5-[(6,7-dichloro-1-oxo-1,2-dihydropyrrolo[1,2-a]pyrazin-4-yl)methyl]-2-fluorobenzoic acid 
• 1196047-05-8 4-chloro-1-(4-chlorobenzyl)-1H-pyrrole-2-carboxylic acid 
• 1253377-02-4 tert-butyl (2R,5S)-5-[(Z,E)-amino({[(4-chloro-1H-pyrrol-2-yl)carbonyl]oxy}imino)methyl]-2-methylpiperidine-1-carboxylate 
• 959771-56-3 1-{[(4-chloro-1H-pyrrol-2-yl)carbonyl]oxy}pyrrolidine-2,5-dione 

Relevant articles and documents

Biosynthesis of pyrrolylpolyenes in Auxarthron umbrinum

The biosynthesis of the pyrrolylpolyene rumbrin (1) in the fungus Auxarthron umbrinum was elucidated using feeding studies with labelled precursors. Incorporation of stable isotopes from [15N]-proline, [13C]-methionine and [13/

PHENYL-3-{ (3- (1H- PYRROL- 2 -YL) - [1 , 2 , 4] 0XADIAZ0L-5-YL] PIPERIDIN-1-YL}-METHANONE DERIVATIVES AND RELATED COMPOUNDS AS POSITIVE ALLOSTERIC MODULATORS OF METABOTROPIC GLUTAMATE RECEPTORS

The present invention provides new compounds of formula (I) as positive allosteric modulators of metabotropic receptors - subtype 5 ("mGluR5") which are useful for the treatment or prevention of central nervous system disorders such as for example, cognitive decline, both positive and negative symptoms in schizophrenia as well as other central or peripheral nervous system disorders in which the mGluR5 subtype of glutamate metabotropic receptor is involved. The invention is also directed to pharmaceutical compounds and compositions in the prevention or treatment of such diseases in which mGluKi is involved. W represents (C4-C7)cycloalkyl, (C3-C7)heterocycloalkyl , (C3-C7)heterocycloalkyl-(C1-C3)alkyl or (C3-C7)heterocycloalkenyl ring; represents a (C5-C7)heteroeycloalkyl, (C5-C7)heterocycloalkeiiyl ring or a heteroaryl group of formula (a), (b), (c), (d), (e), (f), (g), (i). Q denotes a cycloalkyl, an aryl or heteroaryl group of formula (j), (k), (l), (m), (n). A is azo -N=N-, ethyl, ethenyl, ethynyl, -NR8C(=O)-, -NR8C(=O)-O-, -NR8C(=O)-NR9, NR8S(=O)2-, -C(=O)NR8-, -O-C(=O)NR8-, -S-, -S(=O)-, -S(=O)2-, -S(C=O)2NR8-, -C(=0)-0-, -0-C(=0)-, -C(=NR8)NR9-, C(C=NOR8)NR9- , -NR8C(=NOR9)-, =N-0-, -0-N=CH- or a group aryl or heteroaryl of formula, (o), (p), (q), (r), (s), (t), (u), (v), (w), (x). The other substituents are defined in the claims.