27687-46-3

Basic information

• Product Name: (2E)-N-methyl-N,3-diphenylprop-2-enamide
• Synonyms: 2-Propenamide, N-methyl-N,3-diphenyl-
• CAS NO: 27687-46-3
• Molecular Formula: C₁₆H₁₅NO
• Molecular Weight: 237.2964
• Mol File: 27687-46-3.mol
• Article Data: 27

Chemical Properties

• Boiling Point: 360.4°C at 760 mmHg
• Flash Point: 160.4°C
• Density: 1.13g/cm³
• Vapor Pressure: 2.22E-05mmHg at 25°C
• Refractive Index: 1.644
• CAS DataBase Reference: (2E)-N-methyl-N,3-diphenylprop-2-enamide(CAS DataBase Reference)
• NIST Chemistry Reference: (2E)-N-methyl-N,3-diphenylprop-2-enamide(27687-46-3)
• EPA Substance Registry System: (2E)-N-methyl-N,3-diphenylprop-2-enamide(27687-46-3)

Safety Data

• Hazardous Substances Data: 27687-46-3(Hazardous Substances Data)

Usage

Description

(2E)-N-methyl-N,3-diphenylprop-2-enamide is an organic chemical compound with the molecular formula C18H17NO. It features a double bond between the second and third carbon atoms, along with a methyl group and two phenyl groups attached to the nitrogen atom. (2E)-N-methyl-N,3-diphenylprop-2-enamide is a derivative of N,N-diphenylprop-2-en-1-amine and serves as a valuable building block in organic synthesis.

Uses

Used in Pharmaceutical Industry:
(2E)-N-methyl-N,3-diphenylprop-2-enamide is utilized as a starting material for the synthesis of various pharmaceuticals and organic compounds. Its unique structure allows for the creation of a wide range of molecules with potential therapeutic applications.
Used in Organic Synthesis:
In the field of organic synthesis, (2E)-N-methyl-N,3-diphenylprop-2-enamide is employed as a key intermediate for constructing complex organic molecules. Its reactivity and functional groups make it a versatile component in the development of new chemical entities.
Used in Antifungal and Antimicrobial Applications:
(2E)-N-methyl-N,3-diphenylprop-2-enamide has been studied for its potential pharmacological properties, including its use as an antifungal and antimicrobial agent. Its ability to inhibit the growth of certain fungi and bacteria makes it a candidate for further research and development in the area of infectious disease treatment.

Upstream product

• 102-92-1 cinnamoyl chloride 
• 100-61-8 N-methylaniline 
• 201230-82-2 carbon monoxide 
• 536-74-3 phenylacetylene 
• 121-69-7 N,N-dimethyl-aniline 
• 104-55-2 3-phenyl-propenal 
• 538-56-7 cinnamic acid anhydride 
• 621-82-9 Cinnamic acid 
• 62-53-3 aniline 
• 100-62-9 N-methylenebenzenamine 
• 6273-94-5 N-methyl-N-phenylacrylamide 
• 109-65-9 1-bromo-butane 
• 124-38-9 carbon dioxide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 100-61-8 N-methylaniline 
• 122-57-6 1-Phenylbut-1-en-3-one 
• 854880-24-3 3-phenyl-valeric acid-(N-methyl-anilide) 
• 348611-81-4 3,3-diphenyl-propionic acid-(N-methyl-anilide) 
• 1191104-12-7 N-methyl-N,3-diphenyl-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)propanamide 
• 34219-51-7 (E)-1-methyl-3-benzylidene-2,3-dihydro-1H-indol-2-one 
• 34219-52-8 3-benzylidene-1-methyl-1,3-dihydroindol-2-one 
• 2859-29-2 1-methyl-3-phenylquinolin-2(1H)-one 
• 59181-30-5 3-benzylidene-1H-pyrrolo[2,3-b]pyridin-2(3H)-one 

Relevant articles and documents

Cyclobutane-cleavage of anti-head-to-head coumarin and quinolinone homo- and cross-dimers via single- and two-photon-absorption photochemistry

The light-driven cleavage of cyclobutane containing systems via [2 + 2] cycloreversion, such as di-coumarin, is an important yet poorly investigated photochemical reaction. Its applications can be found in smart crosslinking polymers or light-activated drug release. We report the increased cleavage efficiencies of the coumarins lactam analog quinolinone for single-photon as well as two-photon-absorption experiments. To investigate the structure-function relationship of the molecular substitution pattern and its influence on the photoactivity, a coumarin-quinolinone cross-dimer was synthesized and investigated towards its cleavage efficiencies in single-photon as well as two-photon photocleavage. The cross-dimer shows a lower cleavage efficiency than both homo-dimers. The presented results are of interest, e.g., for applications utilizing highly efficient cleavage reactions in symmetric or asymmetric molecular frameworks.

Chlorination Reaction of Aromatic Compounds and Unsaturated Carbon-Carbon Bonds with Chlorine on Demand

Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing Cl3CCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine in situ on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.

Copper-Catalyzed Radical N-Demethylation of Amides Using N-Fluorobenzenesulfonimide as an Oxidant

An unprecedented N-demethylation of N-methyl amides has been developed by use of N-fluorobenzenesulfonimide as an oxidant with the aid of a copper catalyst. The conversion of amides to carbinolamines involves successive single-electron transfer, hydrogen-atom transfer, and hydrolysis, and is accompanied by formation of N-(phenylsulfonyl)benzenesulfonamide. Carbinolamines spontaneously decompose to N-demethylated amides and formaldehyde, because of their inherent instability.