27646-80-6Relevant articles and documents
Jautelat,M.,Roberts,J.D.
, p. 642 - 645 (1969)
2,3-DIHYDROIMIDAZOL[1,2-C]PYRIMIDIN-5(1H)-ONE BASED LIPOPROTEIN-ASSOCIATED PHOSPHOLIPASE A2 (LP-PLA2) INHIBITORS
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Page/Page column 27-28, (2014/08/07)
The present invention relates to novel compounds that inhibit Lp-PLA2 activity, processes for their preparation, to compositions containing them and to their use in the treatment of diseases associated with the activity of Lp-PLA2, for example atherosclerosis, Alzheimer's disease.
Synthesis, conformation, crystal structures and DNA cleavage abilities of tetracyclic analogs of quinocarcin
Williams, Robert M.,Glinka, Tomasz,Gallegos, Renee,Ehrlich, Paul P.,Flanagan, Mark E.,Coffman, Hazel,Park, Gyoosoon
, p. 2629 - 2642 (2007/10/02)
Two totally synthetic, racemic analogs of quinocarcin have been designed and their crystal structures determined. Both substances effect the modest cleavage of plasmid DNA. Alteration of the conformation of the reactive oxazolidine fused to the piperazine