27584-70-9

Basic information

• Product Name: (3H)-OXAZOLONE)
• Synonyms: 2(3H)-oxazolone;2-Hydroxyoxazole;2-Oxazolone;4-Oxazolin-2-one;Oxazol-2(3H)-one;oxazol-2-one;(3H)-OXAZOLONE)
• CAS NO: 27584-70-9
• Molecular Formula: C₃H₃NO₂
• Molecular Weight: 85.06
• Mol File: 27584-70-9.mol
• Article Data: 13

Chemical Properties

• Melting Point: 111-113 °C
• Boiling Point: 219.2 °C at 760 mmHg
• Flash Point: 86.4 °C
• Appearance: /
• Density: 1.296 g/cm³
• Vapor Pressure: 0.0819mmHg at 25°C
• Refractive Index: 1.476
• Storage Temp.: 2-8°C
• PKA: 9.01±0.20(Predicted)
• CAS DataBase Reference: (3H)-OXAZOLONE)(CAS DataBase Reference)
• NIST Chemistry Reference: (3H)-OXAZOLONE)(27584-70-9)
• EPA Substance Registry System: (3H)-OXAZOLONE)(27584-70-9)

Safety Data

• Hazardous Substances Data: 27584-70-9(Hazardous Substances Data)

Usage

Description

(3H)-OXAZOLONE, also known as 2-Oxazolone, is a heterocyclic compound featuring a five-membered ring with two oxygen atoms and one nitrogen atom. It is a valuable and versatile building block in synthetic organic chemistry due to its unique structure and reactivity.

Uses

Used in Synthetic Organic Chemistry:
(3H)-OXAZOLONE is used as an activating group in coupling reactions for [facilitating the formation of new chemical bonds and enhancing the reactivity of molecules].
(3H)-OXAZOLONE is used as a chiral auxiliary in [improving the selectivity and efficiency of asymmetric synthesis, leading to enantiomerically pure products].
Used in Pharmaceutical Industry:
(3H)-OXAZOLONE is used as a reagent in the synthesis of (±)-8α-hydroxystreptazolone, which is a compound with potential pharmaceutical applications [due to its biological activities and therapeutic potential].

InChI:InChI=1/C3H3NO2/c5-3-4-1-2-6-3/h1-2H,(H,4,5)

Upstream product

• 14441-94-2 4-methoxy-1,3-oxazolidin-2-one 
• 126541-67-1 N-<(benzotriazol-1-yl)methyl>(1-phenylethyl)amine 
• 1432-43-5 3-acetyl-1,3-oxazolidin-2-one 
• 60759-49-1 N-acetyl-1,3-oxazol-2-one 
• 618-36-0 rac-methylbenzylamine 
• 530-62-1 1,1'-carbonyldiimidazole 
• 100-47-0 benzonitrile 
• 98-86-2 acetophenone 
• 288-42-6 oxazol 

Downstream Products

• 191033-05-3 1-[3-(5-(1,2,4-triazol-4-yl)-1H-indol-3-yl)propyl]-4-[2-(oxazol-2-on-3-yl)-1-phenylethyl]piperazine 
• 89338-08-9 phenyloxazolone 
• 64843-25-0 3-benzyloxazol-2(3H)-one 
• 344243-61-4 3-propyloxazol-2(3H)-one 
• 1301254-75-0 tetraethyl 6-amino-5,8-dimethylnaphthalene-2,2,3,3-(1H,4H)-tetracarboxylate 
• 1301254-68-1 2,2-bis((benzyloxy)methyl)-4,7-dimethyl-2,3-dihydro-1H-inden-5-amine 
• 1301254-71-6 dimethyl 5-amino-4,7-diisopropyl-1H-indene-2,2(3H)-dicarboxylate 
• 1301254-65-8 2,2,4',7'-tetramethyl-1',3'-dihydrospiro[[1,3]dioxane-5,2'-inden]-5'-amine 
• 1301254-62-5 methyl 5-amino-4,7-dimethyl-2,3-dihydro-1H-indene-2-carboxylate 
• 1301254-70-5 dimethyl 5-amino-4,7-diphenyl-1H-indene-2,2(3H)-dicarboxylate 
• 1301254-76-1 tetraethyl 6-aminonaphthalene-2,2,3,3(1H,4H)-tetracarboxylate 
• 1301254-64-7 4,7-dimethyl-2-tosylisoindolin-5-amine 
• 1301254-61-4 dimethyl 5-amino-4,7-dimethyl-1H-indene-2,2(3H)-dicarboxylate 
• 1301254-63-6 4,7-dimethyl-1,3-dihydroisobenzofuran-5-amine 

Relevant articles and documents

General Synthesis of Secondary Alkylamines by Reductive Alkylation of Nitriles by Aldehydes and Ketones

The development of C?N bond formation reactions is highly desirable due to their importance in biology and chemistry. Recent progress in 3d metal catalysis is indicative of unique selectivity patterns that may permit solving challenges of chemical synthesis. We report here on a catalytic C?N bond formation reaction—the reductive alkylation of nitriles. Aldehydes or ketones and nitriles, all abundantly available and low-cost starting materials, undergo a reductive coupling to form secondary alkylamines and inexpensive hydrogen is used as the reducing agent. The reaction has a very broad scope and many functional groups, including hydrogenation-sensitive examples, are tolerated. We developed a novel cobalt catalyst, which is nanostructured, reusable, and easy to handle. The key seems the earth-abundant metal in combination with a porous support material, N-doped SiC, synthesized from acrylonitrile and a commercially available polycarbosilane.

Compounds which mimic the chemical and biological properties of discodermolide

Compounds which mimic the chemical and/or biological activity of discodermolide are provided and intermediates useful in their preparation.

Synthetic techniques and intermediates for polyhydroxy, dienyl lactone derivatives

Synthetic methods for lactone-containing compounds such as the discodermolides are provided, as are compounds which mimic the chemical and/or biological activity thereof, and methods and intermediates useful in their preparation.