275-02-5

Basic information

• Product Name: 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE
• Synonyms: 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE;1,2,4-TRIAZOLO(1,5-A)PYRIMIDINE 98%
• CAS NO: 275-02-5
• Molecular Formula: C₅H₄N₄
• Molecular Weight: 120.11
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Pyrimidines
• Mol File: 275-02-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 142-145 °C(lit.)
• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.48 g/cm³
• Refractive Index: 1.772
• PKA: 0.70±0.30(Predicted)
• CAS DataBase Reference: 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE(275-02-5)
• EPA Substance Registry System: 1,2,4-TRIAZOLO[1,5-A]PYRIMIDINE(275-02-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-37/39
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 275-02-5(Hazardous Substances Data)

Usage

General Description

1,2,4-Triazolo[1,5-a]pyrimidine is a chemical compound classified in the category of heterocyclic compounds, more specifically, the group of triazolopyrimidines. These compounds are known for their variety in chemical behavior and applications. 1,2,4-Triazolo[1,5-a]pyrimidine, in particular, serves as an essential building block in the synthesis of a range of pharmaceuticals and biologically active molecules. It has aroused considerable interest due to its therapeutic potential, showing anti-inflammatory, analgesic, antitumor, antimicrobial and antiviral properties, amongst others. Its synthesis and derivatization have been explored in various research studies with increasing interest.

InChI:InChI=1/C5H4N4/c1-2-6-5-7-4-8-9(5)3-1/h1-4H

Upstream product

• 7504-94-1 2-pyrimidinylhydrazine 
• 64-18-6 formic acid 
• 61-82-5 3⁽⁵⁾-amino-1,2,4-triazole 
• 122-31-6 malondialdehyde bis(diethyl acetal) 
• 764-63-6 (E)-3-ethoxyacrylaldehyde 
• 61-82-5 3-amino-1,2,4-triazole 
• 927-63-9 3-dimethylaminoacrolein 
• 542-78-9 Malondialdehyde 
• 102-52-3 malonaldehydebis(dimethylacetal) 
• 31592-08-2 4,7-dihydro-1,2,4-triazolo<1,5-a>pyrimidin-7-one 
• 927-63-9 (E)-3-(dimethylamino)acrolein 
• 52341-91-0 7-chloro-[1,2,4]triazolo[1,5-a]pyrimidine 
• 274-98-6 [1,2,4]triazolo[4,3-a]pyrimidine 

Downstream Products

• 160290-42-6 7-(4-chlorophenyl)-1,2,4-triazolo<1,5-a>pyrimidine 
• 39573-72-3 7-phenyl-1,2,4-triazolo<1,5-a>pyrimidine 

Relevant articles and documents

Two different compounds formed from copper(II) tetrafluoridoborate and [1,2,4]triazolo[1,5-a]pyrimidine. Synthesis, spectroscopy and single-crystal structures

Two coordination compounds copper(II) with tetrafluoridoborate as the anion and [1,2,4]triazolo[1,5-a] pyrimidine (abbreviated as tp) as the ligand are presented, together with their crystal structure and spectroscopic properties. A light blue compound [Cu(tp)4 H2O)2](BF 4)2 (CH3OH) (1) with a tetragonal chromophore and a dark blue compound [Cu(tp)5](BF4)2(CH3OH) (2) are formed from the same batch. Compound (2) has a quite unusual geometry for Cu(II) with just 5 tp ligands, homoleptically coordinated to the metal ion. Both compounds show interesting hydrogenbond interactions in the solid state, where coordinated water is intramolecularly bound to non-coordinated N atoms of tp (in 1), and methanol is attached to the anion (in 2). The Author(s) 2010.

Differentiation between [1,2,4]triazolo[1,5-a] pyrimidine and [1,2,4]triazolo[4,3-a]- Pyrimidine regioisomers by 1H-15N HMBC experiments

The condensation of malonoaldehyde derivatives with either a 3-amino-[1,2,4]-triazole or a 3,5-diamino-[1,2,4]-triazole precursor was studied. In agreement with previous reports, two different bicycles, namely, bearing the regioisomeric [1,2,4]triazolo[1,

Triazolo- und -pyrimidine aus 3-Alkoxyacroleinen und 3-Amino-1,2,4-triazolen

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