2739-12-0

Basic information

• Product Name: N-METHYLANILINE HYDROCHLORIDE
• Synonyms: ANILINOMETHANE HYDROCHLORIDE;Hydrochloride N-methylaniline salt;METHYLANILINE HYDROCHLORIDE;TIMTEC-BB SBB008162;n-methylaniliniumchloride;N-METHYLAMINOBENZENE HYDROCHLORIDE;N-METHYLANILINE HYDROCHLORIDE;N-MethylanilineHCl
• CAS NO: 2739-12-0
• Molecular Formula: C7H10ClN
• Molecular Weight: 143.61
• EINECS: 220-363-0
• Mol File: 2739-12-0.mol
• Article Data: 18

Chemical Properties

• Melting Point: 122.7°C
• Boiling Point: 234.4°C (rough estimate)
• Flash Point: 78.9 °C
• Appearance: /
• Density: 1.0660
• Vapor Pressure: 0.402mmHg at 25°C
• Refractive Index: 1.5760 (estimate)
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Chloroform (Sparingly), Methanol (Slightly)
• Stability: Hygroscopic
• CAS DataBase Reference: N-METHYLANILINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: N-METHYLANILINE HYDROCHLORIDE(2739-12-0)
• EPA Substance Registry System: N-METHYLANILINE HYDROCHLORIDE(2739-12-0)

Safety Data

• Hazardous Substances Data: 2739-12-0(Hazardous Substances Data)

Usage

Description

N-METHYLANILINE HYDROCHLORIDE is an organic compound with the chemical formula C7H10ClN. It is a derivative of aniline, where one hydrogen atom of the amino group is replaced by a methyl group. N-METHYLANILINE HYDROCHLORIDE is a white crystalline solid and is known for its various applications in the pharmaceutical and chemical industries.

Uses

Used in Pharmaceutical Industry:
N-METHYLANILINE HYDROCHLORIDE is used as an antithrombotic drug for the prevention and treatment of blood clots. It helps in reducing the risk of heart attacks, strokes, and other thrombotic disorders by inhibiting platelet aggregation and blood coagulation.
Used in Synthesis of Argatroban Monohydrate:
In the pharmaceutical industry, N-METHYLANILINE HYDROCHLORIDE is also utilized in the synthesis method of argatroban monohydrate, which is another antithrombotic drug. Argatroban monohydrate is used to treat patients with heparin-induced thrombocytopenia, a rare but serious blood clotting disorder. The catalytic reduction process involving N-METHYLANILINE HYDROCHLORIDE contributes to the production of this life-saving medication.

Purification Methods

Crystallise the salt from dry *benzene/CHCl3 and dry under vacuum. [Beilstein 12 IV 241.]

InChI:InChI=1/C7H9N.ClH/c1-8-7-5-3-2-4-6-7;/h2-6,8H,1H3;1H

Upstream product

• 100-61-8 N-methylaniline 
• 98-88-4 benzoyl chloride 
• 73551-23-2 N,2,2-trimethyl-N-phenylpropanethioamide 
• 64317-34-6 N-(pentafluorophenyl)carbonimidoyl dichloride 
• 7647-01-0 hydrogenchloride 
• 614-00-6 N-methyl-N-nitrosoaniline 
• 60-29-7 diethyl ether 
• 64-17-5 ethanol 
• 122-39-4 diphenylamine 
• 103-70-8 Formanilid 
• 87463-10-3 (N,N'-dimethyl-N,N'-diphenylcarbamoyl)sulfenamide 
• 3422-01-3 tert-butyl phenylcarbamate 
• 2603-10-3 N-phenyl methyl carbamate 
• 50-00-0 formaldehyd 

Downstream Products

• 108481-98-7 2,N⁴-dimethyl-N⁴-phenyl-pyrimidine-4,6-diyldiamine; hydrochloride 
• 64890-22-8 4-(N-methyl-N-phenylamino)pyridine 
• 95944-83-5 N-methyl-4-trityl-aniline 
• 94-34-8 N-(2-cyanoethyl)-N-methylaniline 
• 4559-87-9 1-methyl-1-phenylurea 
• 90559-25-4 1-Methyl-1-phenyl-biuret 
• 101574-57-6 N-phenylacetyl-glycine-(N-methyl-anilide) 
• 5462-68-0 carbamoylsulfanyl-acetic acid-(N-methyl-anilide) 
• 100-60-7 N-methylcyclohexylamine 
• 7560-83-0 N-Methyldicyclohexylamine 
• 30536-43-7 2-benzyl-1,3-dimethyl-indole 
• 106-49-0 p-toluidine 
• 540-23-8 p-toluidine hydrochloride 
• 121-69-7 N,N-dimethyl-aniline 

Relevant articles and documents

N-Methylaniline-induced Si-Si bond cleavages of perchlorooligosilanes

This study describes Si-Si bond cleavage of perchlorooligosilane using an amine. N-Methylaniline-induced Si-Si bond cleavage reactions of cyclic perchlorosilanes Si5Cl10 (1) and Si4Cl 8 (2), and acyclic perchlor

Formal Aniline Synthesis from Phenols through Deoxygenative N-Centered Radical Substitution

Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.

High-throughput approach for the identification of anilinium-based ionic liquids that are suitable for electropolymerisation

We report the synthesis of new protic ionic liquids (PILs) based on aniline derivatives and the use of high-throughput (HT) techniques to screen possible candidates. In this work, a simple HT method was applied to rapidly screen different aniline derivatives against different acids in order to identify possible combinations that produce PILs. This was followed by repeating the HT process with a Chemspeed robotic synthesis platform for more accurate results. One of the successful combinations were then chosen to be synthesised on a larger scale for further analysis. The new PILs are of interest to the fields of ionic liquids, energy storage and especially, conducting polymers as they serve as solvents, electrolytes and monomers at the same time for possible electropolymerisation (i.e. a self-contained polymer precursor).