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27387-90-2

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  • 27387-90-2 Structure

  • Basic information

    1. Product Name: 3-(3,5-Dichlorophenyl)-1-methylhydantoin
    2. Synonyms: 3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-IMIDAZOLIDINEDIONE;3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-IMIDAZOLIDINONE;3-(3,5-DICHLOROPHENYL)-1-METHYL HYDANTOIN;3-(3,5-Dichlorophenyl)Hydantoin;3-(3,5-DICHLOROPHENYL)-1-METHYLHYDANTOIN(3-(3,5-DICHLOROPHENYL)-1-METHYL-2,4-IMIDAZOLIDINEDIONE)
    3. CAS NO:27387-90-2
    4. Molecular Formula: C10H8Cl2N2O2
    5. Molecular Weight: 259.09
    6. EINECS: N/A
    7. Product Categories: N/A
    8. Mol File: 27387-90-2.mol
    9. Article Data: 6

  • Chemical Properties

    1. Melting Point: 202-203.5 °C(Solv: ethanol (64-17-5))
    2. Boiling Point: 377.293 °C at 760 mmHg
    3. Flash Point: 181.98 °C
    4. Appearance: /
    5. Density: 1.507 g/cm3
    6. Vapor Pressure: 0mmHg at 25°C
    7. Refractive Index: 1.617
    8. Storage Temp.: N/A
    9. Solubility: N/A
    10. PKA: -1.90±0.20(Predicted)
    11. CAS DataBase Reference: 3-(3,5-Dichlorophenyl)-1-methylhydantoin(CAS DataBase Reference)
    12. NIST Chemistry Reference: 3-(3,5-Dichlorophenyl)-1-methylhydantoin(27387-90-2)
    13. EPA Substance Registry System: 3-(3,5-Dichlorophenyl)-1-methylhydantoin(27387-90-2)

  • Safety Data

    1. Hazard Codes: N/A
    2. Statements: N/A
    3. Safety Statements: N/A
    4. WGK Germany:
    5. RTECS:
    6. HazardClass: N/A
    7. PackingGroup: N/A
    8. Hazardous Substances Data: 27387-90-2(Hazardous Substances Data)

27387-90-2 Usage

Description

3-(3,5-Dichlorophenyl)-1-methylhydantoin, commonly known as Diclazuril, is a hydantoin compound that serves as an antiprotozoal drug in veterinary medicine. It is specifically effective against coccidiosis, a parasitic disease impacting the intestinal tracts of animals. Diclazuril operates by inhibiting the development and proliferation of coccidian parasites, thereby preventing and treating the infection. It is characterized by its low toxicity and minimal side effects when administered correctly.

Uses

Used in Veterinary Medicine:
3-(3,5-Dichlorophenyl)-1-methylhydantoin is used as an antiprotozoal agent for the prevention and treatment of coccidiosis in animals. It is particularly effective in controlling the disease in poultry and other livestock due to its ability to inhibit the growth and spread of coccidian parasites.
Used in Poultry and Livestock Industries:
3-(3,5-Dichlorophenyl)-1-methylhydantoin is used as a feed additive in the poultry and livestock industries to manage coccidiosis. Its administration helps in maintaining the health of the animals and improving their productivity by preventing the negative impacts of the parasitic infection.

Check Digit Verification of cas no

The CAS Registry Mumber 27387-90-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,3,8 and 7 respectively; the second part has 2 digits, 9 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 27387-90:
(7*2)+(6*7)+(5*3)+(4*8)+(3*7)+(2*9)+(1*0)=142
142 % 10 = 2
So 27387-90-2 is a valid CAS Registry Number.
InChI:InChI=1/C10H8Cl2N2O2/c1-13-5-9(15)14(10(13)16)8-3-6(11)2-7(12)4-8/h2-4H,5H2,1H3

27387-90-2SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-(3,5-dichlorophenyl)-1-methylimidazolidine-2,4-dione

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:27387-90-2 SDS

27387-90-2Relevant articles and documents

Discovery and development of 5-[(5S,9R)-9-(4-cyanophenyl)-3-(3,5- dichlorophenyl)-1-methyl-2,4-dioxo-1,3,7-triazaspiro[4.4]non-7-yl-methyl] -3-thiophenecarboxylic Acid (BMS-587101) - A small molecule antagonist of leukocyte function associated antigen-1

Potin, Dominiques,Launay, Michele,Monatlik, Francoise,Malabre, Patrice,Fabreguettes, Maud,Fouquet, Andre,Maillet, Magali,Nicolai, Eric,Dorgeret, Lo?c,Chevallier, Fran?ois,Besse, Dominique,Dufort, Monique,Caussade, Fran?ois,Ahmad, Syed Z.,Stetsko, Dawn K.,Skala, Stacey,Davis, Patricia M.,Balimane, Praveen,Patel, Karishma,Yang, Zheng,Marathe, Punit,Postelneck, Jennifer,Townsend, Robert M.,Goldfarb, Valentina,Sheriff, Steven,Einspahr, Howard,Kish, Kevin,Malley, Mary F.,DiMarco, John D.,Gougoutas, Jack Z.,Kadiyala, Pathanjali,Cheney, Daniel L.,Tejwani, Ravindra W.,Murphy, Denette K.,Mcintyre, Kim W.,Yang, Xiaoxia,Chao, Sam,Leith, Leslie,Xiao, Zili,Mathur, Arvind,Chen, Bang-Chi,Wu, Daugh-Rurng,Traeger, Sarah C.,McKinnon, Murray,Barrish, Joel C.,Robl, Jeffrey A.,Iwanowicz, Edwin J.,Suchard, Suzanne J.,Dhar, T. G. Murali

, p. 6946 - 6949 (2006)

LFA-1 (leukocyte function-associated antigen-1), is a member of the β2-integrin family and is expressed on all leukocytes. This letter describes the discovery and preliminary SAR of spirocyclic hydantoin based LFA-1 antagonists that culminated in the iden

Kilogram synthesis of a LFA-1/ICAM inhibitor

Delmonte, Albert J.,Waltermire, Robert E.,Fan, Yu,McLeod, Douglas D.,Gao, Zhinong,Gesenberg, Kirsten D.,Girard, Kevin P.,Rosingana, Miguel,Wang, Xuebao,Kuehne-Willmore, Jennifer,Braem, Alan D.,Castoro, John A.

scheme or table, p. 553 - 561 (2011/07/30)

The process development and the kilogram-scale synthesis of BMS-587101 (1) are described. The synthesis features a [3 + 2] azomethine ylide cycloaddition to efficiently build the spirocyclic core in a diastereoselective fashion followed by a classical res

Crystalline forms and process for preparing spiro-hydantoin compounds

-

Page/Page column 24, (2010/10/20)

A process is provided for preparing spiro-hydantoin compounds of the formula II wherein Z is N or CR4b; K and L are independently O or S; Ar is an optionally substituted aryl or heteroaryl; A2 is a linker, G′ is a linker; Q is a link

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