273-98-3

Basic information

• Product Name: THIAZOLO[4,5-B]PYRIDINE
• Synonyms: THIAZOLO[4,5-B]PYRIDINE;Thiazolo[4,5-b]pyridine (8CI,9CI);[1,3]Thiazolo[4,5-b]pyridine
• CAS NO: 273-98-3
• Molecular Formula: C6H4N2S
• Molecular Weight: 136.178
• Mol File: 273-98-3.mol
• Article Data: 3

Chemical Properties

• Appearance: /
• CAS DataBase Reference: THIAZOLO[4,5-B]PYRIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: THIAZOLO[4,5-B]PYRIDINE(273-98-3)
• EPA Substance Registry System: THIAZOLO[4,5-B]PYRIDINE(273-98-3)

Safety Data

• Hazardous Substances Data: 273-98-3(Hazardous Substances Data)

Usage

General Description

Thiazolo[4,5-b]pyridine is a heterocyclic compound with a fused thiazole and pyridine ring system. It is a potential building block for pharmaceuticals, agrochemicals, and materials due to its unique structure and functional properties. Thiazolo[4,5-b]pyridine derivatives have been studied for their various biological activities, including anti-cancer, anti-inflammatory, anti-tuberculosis, and anti-microbial properties. THIAZOLO[4,5-B]PYRIDINE has also been explored for its potential use in organic electronics and as a ligand in coordination chemistry. Its diverse applications make it an important target in synthetic and medicinal chemistry research.

Upstream product

• 104830-06-0 3-iodo-2-aminopyridine 
• 67-68-5 dimethyl sulfoxide 
• 13575-41-2 [1,3]thiazolo[4,5-b]pyridin-2-amine 
• 13534-99-1 2-Amino-3-bromopyridine 

Relevant articles and documents

Synthetic method of ammonium acetate-mediated benzothiazole compound

The invention discloses a synthetic method of an ammonium acetate-mediated benzothiazole compound . The synthetic method comprises the steps: adding an o-haloaniline derivative, potassium sulfide, dimethyl sulfoxide, a catalyst, an additive 1 and an additive 2 into a reaction tube, carrying out a stirring reaction at the temperature of 130-150 DEG C, cooling to room temperature after the reactionis finished, and separating and purifying the product to obtain the benzothiazole compound. The invention provides the synthetic method of the benzothiazole compound by taking K2S as a sulfur source,DMSO as a carbon source and an oxidizing agent, an o-haloaniline derivative as a substrate and an ammonium acetate mediated three-component one-pot method. The method has the advantages of fewer reaction steps, mild reaction conditions, good functional group tolerance and the like.

A thiazole pyridine compound and its preparation method

The invention relates to a thiazole pyridine compound and its preparation method. The compound is thiazolo(4,5-b)pyridine. The preparation method comprises the following steps: (1) a compound 13-bromine-2-aminopyridine is used as a starting material to react in the presence of benzoyl chloride and ammonium thiocyanate so as to obtain a benzoyl-protected thiourea-containing derivative compound 2; (2) the compound 2 undergoes hydrolysis to obtain a thiourea derivative compound; (3) the compound 3 undergoes ring closure under the action of NaH to generate a compound 4; and (4) the compound 4 undergoes deamination by the use of isoamyl nitrite to obtain a target product compound 5. According to the method, raw materials are cheap and easily available. The synthetic method is simple. The preparation method meets requirements of large-scale industrial production.