27088-83-1

Basic information

• Product Name: 2-p-tolylthiazole
• Synonyms: 2-p-tolylthiazole
• CAS NO: 27088-83-1
• Molecular Formula: C₁₀H₉NS
• Molecular Weight: 175.2502
• Mol File: 27088-83-1.mol
• Article Data: 15

Chemical Properties

• Boiling Point: 290.1 °C at 760 mmHg
• Flash Point: 132.3 °C
• Appearance: /
• Density: 1.14 g/cm³
• Vapor Pressure: 0.00368mmHg at 25°C
• Refractive Index: 1.593
• CAS DataBase Reference: 2-p-tolylthiazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-p-tolylthiazole(27088-83-1)
• EPA Substance Registry System: 2-p-tolylthiazole(27088-83-1)

Safety Data

• Hazardous Substances Data: 27088-83-1(Hazardous Substances Data)

Usage

Description

2-p-tolylthiazole is a heterocyclic aromatic compound that belongs to the thiazole group. It features a five-membered ring structure composed of four carbon atoms, one sulfur atom, and a nitrogen atom. This versatile chemical compound is widely recognized for its potential applications across various industries.

Uses

Used in Pharmaceutical and Agrochemical Industries:
2-p-tolylthiazole is utilized as a key building block in the synthesis of pharmaceuticals and agrochemicals due to its unique chemical properties and potential therapeutic effects.
Used in Antimicrobial Applications:
In the field of antimicrobial agents, 2-p-tolylthiazole is employed as an antimicrobial substance, leveraging its ability to combat various microorganisms and inhibit their growth.
Used in Antitumor Applications:
2-p-tolylthiazole is used as an antitumor agent, contributing to the development of new drugs that target and inhibit the growth of cancer cells.
Used in Anti-inflammatory Applications:
2-p-tolylthiazole is also used as an anti-inflammatory agent, helping to reduce inflammation and associated symptoms in various medical treatments.
Used in Organic Electronic Materials:
2-p-tolylthiazole is utilized in the fabrication of organic electronic materials, such as organic light-emitting diodes (OLEDs) and organic solar cells, due to its electronic properties and stability.
Used as a Corrosion Inhibitor in Industrial Applications:
In industrial settings, 2-p-tolylthiazole serves as a corrosion inhibitor, protecting materials from degradation and extending their service life.

InChI:InChI=1/C10H9NS/c1-8-2-4-9(5-3-8)10-11-6-7-12-10/h2-7H,1H3

Upstream product

• 2362-62-1 4-methylthiobenzamide 
• 15873-56-0 monochloroacetaldehyde hydrate 
• 288-47-1 1,3-thiazole 
• 106-38-7 para-bromotoluene 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 36719-51-4 3,3-diethyl-1-(4-methylphenyl)-1-triazene 
• 106-49-0 p-toluidine 
• 459-44-9 4-methylbenzenediazonium tetrafluoroborate 
• 623-13-2 4-methylphenyl methylsulfide 
• 624-31-7 4-tolyl iodide 
• 25563-06-8 N-methoxy-4-methylbenzamide 
• 3034-52-4 2-chlorothiazole 
• 149104-90-5 4-acetylphenylboronic acid 
• 17157-48-1 bromoacetaldehyde 

Downstream Products

• 1000029-33-3 2-(4-methylphenyl)-5-(4-nitrophenyl)thiazole 
• 1000029-32-2 5-(4-chlorophenyl)-2-(4-methylphenyl)thiazole 
• 132360-38-4 2,5-bis(4-methylphenyl)thiazole 
• 72997-55-8 5-(4-methoxyphenyl)-2-(4-methylphenyl)thiazole 
• 16112-22-4 2-(4-methylphenyl)-5-phenylthiazole 
• 75601-35-3 2-mesitylthiazole 
• 2227-61-4 4-phenyl-2-(4′-methylphenyl)thiazole 
• 1393673-11-4 C₂₀H₁₆N₂S₂ 
• 1393673-09-0 4-bromo-5-iodo-2-tolylthiazole 
• 1142196-28-8 4-bromo-2-tolylthiazole 
• 1086382-54-8 5-bromo-2-tolylthiazole 
• 1393673-25-0 C₄₀H₂₈N₄S₄ 
• 1393673-24-9 C₂₀H₁₄Br₂N₂S₂ 
• 1393673-23-8 2,2'-di-p-tolyl-4,4'-bithiazole 

Relevant articles and documents

Photoinduced Heterogeneous C?H Arylation by a Reusable Hybrid Copper Catalyst

Heterogeneous copper catalysis enabled photoinduced C?H arylations under exceedingly mild conditions at room temperature. The versatile hybrid copper catalyst provided step-economical access to arylated heteroarenes, terpenes and alkaloid natural products with various aryl halides. The hybrid copper catalyst could be reused without significant loss of catalytic efficacy. Detailed studies in terms of TEM, HRTEM and XPS analysis of the hybrid copper catalyst, among others, supported its outstanding stability and reusability.

Palladium-catalyzed direct C2-arylation of azoles with aromatic triazenes

A highly efficient palladium-catalyzed arylation of azoles at the C2-position using 1-aryltriazenes as aryl reagents was developed. Azoles including oxazoles, thiazoles, imidazoles, 1,3,4-oxadiazoles, and oxazolines could react with 1-aryltriazenes smoothly to generate the corresponding products in good to excellent yields, and various substitution patterns were tolerated toward the reaction.

Palladium-Catalyzed Zinc-Amide-Mediated C-H Arylation of Fluoroarenes and Heteroarenes with Aryl Sulfides

C-H arylation of polyfluoroarenes and heteroarenes with aryl sulfides proceeds smoothly with the aid of a palladium-N-heterocyclic carbene catalyst. A bulky zinc amide, TMPZnCl an effective base to generate the corresponding arylzinc species in situ. This arylation protocol is practically much easier to perform than our previous method, which necessitates preparation of the arylzinc reagents in advance from the corresponding aryl halides. Aryl sulfides that are prepared through sulfur-specific reactions, such as SNAr sulfanylation and extended Pummerer reactions, undergo this direct arylation, offering interesting transformations that are otherwise difficult to achieve with conventional halogen-based organic synthesis.