26944-48-9 Usage
Description
Glibornuride, also known by its brand name Glutril, is a pharmaceutical compound developed by Hoffmann-LaRoche. It is a second-generation sulfonylurea derivative that functions as an antidiabetic drug. Glibornuride works by stimulating the release of insulin from the pancreatic beta cells, which helps in the regulation of blood sugar levels. It is particularly effective in managing type 2 diabetes mellitus.
Uses
Used in Pharmaceutical Industry:
Glibornuride is used as an antidiabetic agent for the treatment of type 2 diabetes mellitus. It helps in controlling blood sugar levels by promoting the release of insulin from the pancreatic beta cells, thus assisting in the regulation of glucose metabolism.
Additionally, Glibornuride has been shown to have potential applications in other areas, such as:
1. Airway Smooth Muscle Relaxation:
Glibornuride is used as a relaxant for airway smooth muscle relaxation. It has been demonstrated to antagonize the relaxant response to the K+ channel opener cromakalim, which can be beneficial in treating conditions related to airway constriction.
2. Lactic Acidosis and Hypoglycemia Management:
Glibornuride is associated with the management of lactic acidosis and hypoglycemia in patients with type 2 diabetes mellitus. By regulating insulin release and glucose metabolism, it can help prevent or mitigate the onset of these complications.
Originator
Glutril,Roche,W. Germany,1972
Manufacturing Process
2.1 grams of 3-endo-aminoborneol hydrochloride and 2.4 grams of O-methylN-p-toluene-sulfonyl-urea are heated at 125°C for 3 hours with 2 ml of
dimethylformamide. After cooling, the reaction mixture is stirred with 100 ml
of water for 10 minutes, while a pH of 3.5 is maintained by the addition of a
few drops of dilute hydrochloric acid. The precipitate is removed by filtration,
washed with water and suspended in 100 ml of water. The suspension is
dissolved by the addition of 20 ml of 1 N caustic soda. The alkaline solution is
extracted with ether, acidified with dilute hydrochloric acid and filtered. The
precipitate is washed with water and recrystallized from alcohol/water to yield
1-(p-toluene-sulfonyl)-3-(2-endo-hydroxy-3-endo-bornyl)-urea having a
melting point of 193° to 195°C.
Therapeutic Function
Oral hypoglycemic
Check Digit Verification of cas no
The CAS Registry Mumber 26944-48-9 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,6,9,4 and 4 respectively; the second part has 2 digits, 4 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 26944-48:
(7*2)+(6*6)+(5*9)+(4*4)+(3*4)+(2*4)+(1*8)=139
139 % 10 = 9
So 26944-48-9 is a valid CAS Registry Number.
InChI:InChI=1/C18H26N2O4S/c1-11-5-7-12(8-6-11)25(23,24)20-16(22)19-14-13-9-10-18(4,15(14)21)17(13,2)3/h5-8,13-15,21H,9-10H2,1-4H3,(H2,19,20,22)
26944-48-9Relevant articles and documents
USE OF SUBSTITUTED 2 PHENYLBENZIMIDAZOLES AS MEDICAMENTS
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, (2008/06/13)
The present invention relates to the use of a substituted 2-phenylbenzimidazole of formula I wherein R1, R2, R3, R 4, R5 and m have the meanings given in the claims, for the preparation of a medicament for the treatment or prevention of diseases involving glucagon receptors, as well as new compounds of formula I wherein R1 is a group of formula
