26744-15-0

Basic information

• Product Name: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE
• Synonyms: (R)-4-METHOXYPHENYL GLYCIDYL ETHER;(2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE
• CAS NO: 26744-15-0
• Molecular Formula: C10H12O3
• Molecular Weight: 180.2
• Mol File: 26744-15-0.mol
• Article Data: 60

Chemical Properties

• Boiling Point: 287.9 °C at 760 mmHg
• Flash Point: 95.5 °C
• Appearance: /
• Density: 1.142 g/cm³
• CAS DataBase Reference: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE(CAS DataBase Reference)
• NIST Chemistry Reference: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE(26744-15-0)
• EPA Substance Registry System: (2R)-2-[(4-METHOXYPHENOXY)METHYL]OXIRANE(26744-15-0)

Safety Data

• Hazardous Substances Data: 26744-15-0(Hazardous Substances Data)

Usage

General Description

(2R)-2-[(4-Methoxyphenoxy)methyl]oxirane is a chemical compound that belongs to the class of epoxides. It contains a 2R stereochemistry and consists of a three-membered ring with an oxygen atom. The compound is characterized by the presence of a methoxy group and a phenoxy group attached to a 2-carbon chain, which is in turn part of the oxirane ring. This chemical is used in various industrial and research applications, including as a reagent for organic synthesis and as a building block for the production of pharmaceuticals and agrochemicals. Its unique structure and properties make it a valuable tool in the development of new compounds and materials.

Upstream product

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Downstream Products

• 32569-58-7 1-(4-methoxy-phenoxy)-3-piperidin-1-yl-propan-2-ol 
• 391901-52-3 [2-(4-amino-phenyl)-ethyl]-[2-hydroxy-3-(4-methoxy-phenoxy)-propyl]-carbamic acid tert-butyl ester 
• 1414941-74-4 1-(4-methoxyphenoxy)-3-[4-[3-(3-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol 
• 1414941-75-5 1-(4-methoxyphenoxy)-3-[4-[3-(4-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol 
• 1414941-73-3 1-(4-methoxyphenoxy)-3-[4-[3-(2-pyridyl)-2-pyridyl]piperazin-1-yl]propan-2-ol 
• 1607802-83-4 1-(4-methoxyphenoxy)-3-[4-[2-(3-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-84-5 1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-82-3 1-(4-methoxyphenoxy)-3-[4-[2-(2-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-86-7 (R)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 
• 1607802-87-8 (S)-1-(4-methoxyphenoxy)-3-[4-[2-(4-pyridyl)-3-pyridyl]piperazin-1-yl]-2-propanol 

Relevant articles and documents

Design, synthesis and biological evaluation of imidazole and triazole-based carbamates as novel aromatase inhibitors

In the search for novel aromatase inhibitors, a series of triazole and imidazole-based carbamate derivatives were designed and synthesized. Final compounds were thus evaluated against human aromatase by in vitro kinetic experiments in a fluorimetric assay in comparison with letrozole. The effect of most active derivatives 13a and 15c was then evaluated in vitro on the human breast cancer cell line MCF7 by MTT assay, cytotoxicity assay (LDH release) and cell cycle analysis, revealing a dose-dependent inhibition profile of cell viability and low micromolar IC50 values. In addition, docking simulations were also carried out to elucidate at a molecular level of detail the binding modes adopted to target human aromatase.

Substituted diaryl compound and preparation method and application thereof

The invention relates to the field of medicinal chemistry, in particular to a substituted diaryl compound (I). The preparation method comprises the following steps: medicine preparation and medical application thereof. Test results show that the substituted diaryl compound has a good inhibition effect on human lung cancer (A549), human ovarian cancer (SKOV3), human melanoma (A375) and human colon cancer (LOVO) cells. Formula (I):

Chemoselective Epoxidation of Allyloxybenzene by Hydrogen Peroxide Over MFI-Type Titanosilicate

The chemoselective synthesis of 2-(phenoxymethyl)oxirane from allyloxybenzene is achieved with over 90 % yield in a sustainable reaction system using titanium-substituted silicalite-1 (TS-1) as a catalyst, hydrogen peroxide (H2O2) as an oxidant, and a mixture of MeOH/MeCN as a solvent at 40 °C. No acid-catalyzed side reactions prompted by the Lewis acidity of the Ti active site in TS-1 are observed. The TS-1 catalyst can also promote the formation of oxiranes from various p-substituted allyloxybenzenes in good yields. The reaction mechanism is investigated through the reaction with other allyloxy compounds. The results, which are supported by DFT calculations, indicate that an active species of Ti peroxides formed from the reaction of TS-1 with H2O2 selectively oxidizes the allyloxybenzene to 2-(phenoxymethyl)oxirane.