265648-23-5

Basic information

• Product Name: N-<3-Benzoyl-4-(2-phenylacetylamino)phenyl>-N^α-tert-butyloxycarbonyl-S-tritylcysteine amide
• CAS NO: 265648-23-5
• Molecular Weight: 775.968
• Mol File: 265648-23-5.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: N-<3-Benzoyl-4-(2-phenylacetylamino)phenyl>-N^α-tert-butyloxycarbonyl-S-tritylcysteine amide(CAS DataBase Reference)
• NIST Chemistry Reference: N-<3-Benzoyl-4-(2-phenylacetylamino)phenyl>-N^α-tert-butyloxycarbonyl-S-tritylcysteine amide(265648-23-5)
• EPA Substance Registry System: N-<3-Benzoyl-4-(2-phenylacetylamino)phenyl>-N^α-tert-butyloxycarbonyl-S-tritylcysteine amide(265648-23-5)

Safety Data

• Hazardous Substances Data: 265648-23-5(Hazardous Substances Data)

Upstream product

• 265648-21-3 N-(2-benzoyl-4-nitrophenyl)-2-phenylacetamide 
• 1775-95-7 2-amino-5-nitrobenzophenone 
• 103-80-0 phenylacetyl chloride 
• 21947-98-8 N-tert-butyloxycarbonyl-S-trityl-L-cysteine 
• 265648-22-4 N-(4-amino-2-benzoylphenyl)phenylacetic acid amide 

Relevant articles and documents

Different amino acid replacements in CAAX-tetrapeptide based peptidomimetic farnesyltransferase inhibitors

In a series of CAAX-tetrapeptide based farnesyltransferase inhibitors it has been shown that the central AA-dipeptide can be replaced by tranexamic acid, 4-aminobenzenesulfonic acid, and 3-amino-N-(2,3- dimethylphenyl)benzenesulfonamide, respectively, yielding inhibitors active in the low micromolar range. Lipophilic derivatives of these compounds showed moderate antiproliferative activity against different tumor cell lines. A promising class of peptidomimetic farnesyltransferase inhibitors was discovered through the replacement of the terminal AAX motif of the CAAX- tetrapeptide by 2-acylamino-5-aminobenzophenones.