2605-68-7

Basic information

• Product Name: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE
• Synonyms: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE;2-(Triphenylphosphoranylidene)-propanoic acid methyl ester;2-(Triphenylphosphoranylidene)propionic acid methyl ester;Methyl 2-(triphenylphosphoranediyl)propionate;Methyl 2-(triphenylphosphoranylidene)propanoate
• CAS NO: 2605-68-7
• Molecular Formula: C₂₂H₂₁O₂P
• Molecular Weight: 348.37
• Mol File: 2605-68-7.mol
• Article Data: 13

Chemical Properties

• Melting Point: 153-156℃ (ethyl acetate )
• Boiling Point: 485.8±28.0 °C(Predicted)
• Appearance: /
• Density: 1.16±0.1 g/cm3 (20 ºC 760 Torr)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE(2605-68-7)
• EPA Substance Registry System: 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE(2605-68-7)

Safety Data

• Hazardous Substances Data: 2605-68-7(Hazardous Substances Data)

Usage

Description

1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE, also known as methoxycarbonyl phosphorane, is a chemical compound belonging to the phosphorane family. It has the molecular formula C24H20O2P and is characterized by a phosphorous atom surrounded by four different groups in a tetrahedral arrangement with a formal charge of +1. The "1-methoxycarbonyl" refers to the ethylidene group (-CH2-) attached to a methoxy carbonyl (-COOCH3) group. This unique combination of features makes it a potentially interesting compound for further exploration in various chemical reactions.

Uses

Currently, there is limited public information regarding the specific applications of 1-METHOXYCARBONYLETHYLIDENETRIPHENYLPHOSPHORANE. However, given its unique structure and properties, it may be used in various chemical reactions and processes in the fields of organic chemistry, pharmaceuticals, and materials science. Further research and development are needed to fully understand and exploit its potential applications.

Upstream product

• 56904-90-6 (1-methoxy-1-oxopropan-2-yl)triphenylphosphonium iodide 
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• 21204-67-1 methyl (triphenylphosphoranylidene)acetate 
• 1779-58-4 (methyloxycarbonylmethyl)triphenylphosphonium bromide 
• 56905-18-1 methyl 2-iodopropionate 

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Relevant articles and documents

SYNTHESIS AND DETERMINATION OF THE ABSOLUTE CONFIGURATION OF THE MACROLIDE (+)-CONGLOBATIN

(+)-Conglobatin is synthesized from (-)-(2S,4R)-2,4-dimethyl glutaric acid halfester in 15 steps (total yield 4.4percent).The synthesis proves the sense of chirality of the natural (-)-conglobatin to be opposite to the one previously assigned.

7-Step total synthesis of (+)-EBC-329: Photoisomerisation reveals new: Seco -casbane family member

The first seco-casbane, EBC-329, isolated from the Australian rainforest, was synthesised from (+)-2-carene in seven steps. This endeavour not only established the absolute stereochemical assignment as (8R,9S)-EBC-329, but also identified, via photoisomer

Ring-closing metathesis approaches towards the total synthesis of rhizoxins

Efforts are described towards the total synthesis of the bacterial macrolide rhizoxin F, which is a potent tubulin assembly and cancer cell growth inhibitor. A significant amount of work was expanded on the construction of the rhizoxin core macrocycle by ring-closing olefin metathesis (RCM) between C(9) and C(10), either directly or by using relay substrates, but in no case was ringclosure achieved. Macrocycle formation was possible by ring-closing alkyne metathesis (RCAM) at the C(9)/C(10) site. The requisite diyne was obtained from advanced intermediates that had been prepared as part of the synthesis of the RCM substrates. While the direct conversion of the triple bond formed in the ring-closing step into the C(9)-C(10) E double bond of the rhizoxin macrocycle proved to be elusive, the corresponding Z isomer was accessible with high selectivity by reductive decomplexation of the biscobalt hexacarbonyl complex of the triple bond with ethylpiperidinium hypophosphite. Radical-induced double bond isomerization, full elaboration of the C(15) side chain, and directed epoxidation of the C(11)-C(12) double bond completed the total synthesis of rhizoxin F.

NOVEL LACTAM DERIVATIVES HAVING THERAPEUTIC EFFECT ON CANCERS

The present invention relates to a novel lactam derivative having a cancer therapeutic effect or a pharmaceutically acceptable salt thereof and a pharmaceutical composition containing the same as an active ingredient. The novel lactam derivative in accordance with the present invention is capable of selectively and effectively inhibiting the growth of cancer cells, that is B-cell non-Hodgkinandprime;s lymphoma, thereby being usefully used as a pharmaceutical composition for treating cancer or inhibiting the growth of cancer cells.COPYRIGHT KIPO 2015