25914-44-7

Basic information

• Product Name: 5,10-diphenyl-11H-benzofluorene

Upstream product

• 5471-63-6 1,3-diphenylisobenzofuran 
• 95-13-6 1-indene 
• 26129-29-3 trans-2-Benzyliden-1-diphenylmethylenindan 
• 96271-41-9 2-Benzyliden-1-diphenylmethylen-indan 
• 7647-01-0 hydrogenchloride 
• 64-17-5 ethanol 
• 59046-72-9 o-(phenylethynyl)benzaldehyde 
• 141-97-9 ethyl acetoacetate 
• 184155-05-3 diphenyl(2,2-diphenyl-1-iodoethenyl)phosphine oxide 

Relevant articles and documents

Copper(II)-catalyzed asymmetric henry reaction of o-alkynylbenzaldehydes followed by gold(I)-mediated cycloisomerization: An enantioselective route to chiral 1 H-isochromenes and 1,3-dihydroisobenzofurans

By combining the copper(II)-catalyzed asymmetric Henry reaction of o-alkynylbenzaldehydes with subsequent gold(I)-catalyzed cycloisomerization, optically active 1H-isochromenes and 1,3-dihydroisobenzofurans were successfully synthesized in good overall yields with good to excellent enantioselectivities (up to 98%). Various substrates were investigated, and a correlation between the regioselectivity and electronic nature of the substrates was studied. The substrates with electro-donating groups at the alkynyl moiety preferred a 6-endo-dig manner to generated 1H-isochromenes 3 as main products (up to >30:1) while the ones with electron-withdrawing groups were inclined to undergo 5-exo-dig cyclization to form 1,3-dihydroisobenzofurans 4 (up to 1:5).