258279-04-8

Basic information

• Product Name: GHRELIN (HUMAN)
• Synonyms: H-GLY-SER-SER(OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;H-GLY-SER-[SER(N-OCTANOYL)]-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG-OH;GLY-SER-SER(N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GLY-SER-SER(O-N-OCTANOYL)-PHE-LEU-SER-PRO-GLU-HIS-GLN-ARG-VAL-GLN-GLN-ARG-LYS-GLU-SER-LYS-LYS-PRO-PRO-ALA-LYS-LEU-GLN-PRO-ARG;GHRELIN (HUMAN);GHRELIN (HUMAN) TRIFLUOROACETATE;GHRELIN TRIFLUOROACETATE SALT;GS-S(N-OCTANOYL)-FLSPEHQRVQQRKESKKPPAKLQPR
• CAS NO: 258279-04-8
• Molecular Formula: C149H249N47O42
• Molecular Weight: 3370.86
• Product Categories: Peptide;Ghrelin receptor;Peptide Receptors;Cytokine
• Mol File: 258279-04-8.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Density: 1.49±0.1 g/cm3(Predicted)
• Storage Temp.: -15°C
• Solubility: Soluble in H2O
• Water Solubility: Soluble in water, and 5% acetic acid.
• CAS DataBase Reference: GHRELIN (HUMAN)(CAS DataBase Reference)
• NIST Chemistry Reference: GHRELIN (HUMAN)(258279-04-8)
• EPA Substance Registry System: GHRELIN (HUMAN)(258279-04-8)

Safety Data

• Hazardous Substances Data: 258279-04-8(Hazardous Substances Data)

Usage

Description

Ghrelin (human) is an endogenous ligand for the growth hormone secretagogue receptor, primarily synthesized in the stomach. It is a peptide consisting of 28 amino acids, with the serine 3 residue being n-octanoylated, which is essential for its biological activity. Ghrelin plays a crucial role in stimulating food intake and signaling to hypothalamic regulatory nuclei that control energy homeostasis.

Uses

Used in Pharmaceutical Industry:
Ghrelin (human) is used as a growth hormone secretagogue receptor (GHS-R) activator for its ability to potently stimulate growth hormone release from the pituitary gland both in vivo and in vitro. This application is particularly relevant in the development of treatments for growth hormone deficiencies and related conditions.
Used in Nutrition and Obesity Research:
Ghrelin (human) is used as a research tool for understanding the regulation of appetite and energy balance. Its role in stimulating food intake and signaling to hypothalamic regulatory nuclei makes it a valuable compound for studying the underlying mechanisms of obesity and the development of potential therapeutic interventions.
Used in Endocrinology:
Ghrelin (human) is used as a diagnostic marker in endocrinology, particularly in the assessment of growth hormone secretion and the function of the pituitary gland. Its ability to stimulate growth hormone release can help in the diagnosis and monitoring of various endocrine disorders.

Biological Activity

ghrelin is a specific endogenous ligand for the ghs receptor which can stimulate strong increase in circulating gh levels both in vitro and in vivo in a dose-dependent manner, human acylated ghrelin is the major active form that can cross the blood-brain barrier, and has an effection on the activity of arcute neurones with a much stronger affinity (ic50, 0.3×10-9m) than ghsr antagonist (d-lys3)-ghrp-6 (ic50, 0.9×10-6m)[1].ghrelin has effects in stimulating appetite, increasing secretion of gh and hypo-catabolism, improvement of gastrointestinal motility, increasing cardiac output, improvement of pulmonary function and anti-inflammatory effect.clinical applications of ghrelin in total gastrectomy, esophagectomy and neoadjuvant chemotherapy can stimulate food intake, improve guality of life scores and minimize adverse events. recently, ghrelin as a effective approach in the management of anorexia nervosa[2],cachexia[3], bw[4] and appetite loss[5], systemic inflammatory response[6]and cancer[7]. in conclusion, ghrelin is a promising candidate for treating catabolic states and enhancing immune function in cachexia or acquired immunodeficiency syndrome, as well as for treating eating disorders such as obesity and anorexia nervosa.

references

1. m. traebert,* t. riediger,? s. whitebread,* e. scharrer? and h. a. schmid*. ghrelin acts on leptin-responsive neurones in the rat arcuate nucleus. journal of neuroendocrinology, 2002, vol. 14, 580–5862. hotta m, ohwada r, akamizu t, shibasaki t, takano k, kangawa k. ghrelin increases hunger and food intake in patients with restricting-type anorexia nervosa: a pilot study. endocr j. 2009;56:1119–28.3. nagaya n, itoh t, murakami s, oya h, uematsu m, miyatake k, et al. treatment of cachexia with ghrelin in patients with copd. chest. 2005;128:1187–93.4. adachi s, takiguchi s, okada k, yamamoto k, yamasaki m, miyata h, et al. effects of ghrelin administration after total gastrectomy: a prospective, randomized, placebo-controlled phase ii study. gastroenterology. 2010;138:1312–20.5. hiura y, takiguchi s, yamamoto k, kurokawa y, yamasaki m, nakajima k, et al. fall in plasma ghrelin concentrations after cisplatin-based chemotherapy in esophageal cancer patients. int j clin oncol. 2012;17:316–23.6. cheyuo c, jacob a, wang p. ghrelin-mediated sympathoinhibition and suppression of inflammation in sepsis. am j physiol endocrinol metab. 2012;302:e265–72.7. yoshida n, watanabe m, baba y, iwagami s, ishimoto t, iwatsuki m, et al. risk factors for pulmonary complications after esophagectomy for esophageal cancer. surg today. 2014;44:526–32.