25412-62-8

Basic information

• Product Name: 3-CHLORO-BENZAMIDINE
• Synonyms: 3-CHLORO-BENZAMIDINE;3-Chlorobenzene-1-carboximidamide;3-Chlorobenzenecarboximidamide;m-Chlorobenzamidine;3-ChlorobenziMidaMide;3-chlorobenziMidaMide hydrochloride;BenzenecarboxiMidaMide, 3-chloro-
• CAS NO: 25412-62-8
• Molecular Formula: C₇H₇ClN₂
• Molecular Weight: 154.6
• Product Categories: pharmacetical
• Mol File: 25412-62-8.mol
• Article Data: 5

Chemical Properties

• Melting Point: 131-133 °C
• Boiling Point: 254.7 °C at 760 mmHg
• Flash Point: 107.8 °C
• Appearance: /
• Density: 1.29
• Vapor Pressure: 0.017mmHg at 25°C
• Refractive Index: 1.597
• Storage Temp.: 2-8°C
• PKA: 11.09±0.50(Predicted)
• CAS DataBase Reference: 3-CHLORO-BENZAMIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 3-CHLORO-BENZAMIDINE(25412-62-8)
• EPA Substance Registry System: 3-CHLORO-BENZAMIDINE(25412-62-8)

Safety Data

• Hazardous Substances Data: 25412-62-8(Hazardous Substances Data)

Usage

General Description

3-Chloro-Benzamidine, also known as 3672-72-1, is a chemical compound characterized by its benzamidine structure with a chlorine atom attached to the third position of its benzene ring. Benzamidine derivatives, such as this one, are known for their biological activity which includes inhibition of certain enzymes like serine proteases. Notably, the compound's properties related to reactivity, physical characteristics, safety, and handling require appropriate caution and protective measures. However, detailed scientific research is lacking for the full understanding of its potential applications and hazards.

InChI:InChI=1/C7H7ClN2/c8-6-3-1-2-5(4-6)7(9)10/h1-4H,(H3,9,10)

Upstream product

• 766-84-7 3-chloro-benzonitrile 
• 84738-98-7 amino(methyl)aluminum chloride 

Downstream Products

• 106690-56-6 2-(3-chlorophenyl)-pyrimidin-4-one 
• 1431952-33-8 2-[2-(3-chlorophenyl)-4-(4-hydroxyphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide 
• 1431952-32-7 2-{2-(3-chlorophenyl)-4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]-1H-imidazol-1-yl}-N-(propan-2-yl)acetamide 
• 1431952-10-1 2-{2-(3-chlorophenyl)-4-[4-(2-hydroxyethyl)phenyl]-1H-imidazol-1-yl}-N-(propan-2-yl)acetamide 
• 1431952-09-8 2-[2-(3-chlorophenyl)-4-(4-ethenylphenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide 
• 1431952-07-6 2-[4-(4-bromophenyl)-2-(3-chlorophenyl)-1H-imidazol-1-yl]-N-(propan-2-yl)acetamide 

Relevant articles and documents

Novel Allosteric Inhibitors of Deoxyhypusine Synthase against Malignant Melanoma: Design, Synthesis, and Biological Evaluation

Based on the novel allosteric site of deoxyhypusine synthase (DHPS), two series of 30 novel 5-(2-methoxyphenoxy)-2-phenylpyrimidin-4-amine derivatives as DHPS inhibitors were designed and synthesized. Among them, compound8m, with the best DHPS inhibitory potency (IC50= 0.014 μM), exhibited excellent inhibition against melanoma cells, which was superior to that of GC7. Besides, molecular docking and molecular dynamics (MD) simulations further proved that compound8mwas tightly bound to the allosteric site of DHPS. Flow cytometric analysis and enzyme-linked immunosorbent assay (ELISA) showed that compound8mcould inhibit the intracellular reactive oxygen species (ROS) level. Furthermore, by western blot analysis, compound8meffectively activated caspase 3 and decreased the expressions of GP-100, tyrosinase, eIF5A2, MMP2, and MMP9. Moreover, both Transwell analysis and wound healing analysis showed that compound8mcould inhibit the invasion and migration of melanoma cells. In thein vivostudy, the tumor xenograft model showed that compound8meffectively inhibited melanoma development with low toxicity.

CARBOXAMIDE INHIBITORS OF TGFB

Certain appropriately substituted forms of pyrimidine having a pyridylamine group at C- 4 of the pyrimidine and an amide group on the pyridine ring are useful in the treatment of conditions associated with excessive TGFB activity.

Pteridinecarboxamide diuretics. I. Reaction of 4,6-diamino-5-nitrosopyrimidines with substituted malonamides.

-