25249-16-5

Basic information

• Product Name: POLY(2-HYDROXYETHYL METHACRYLATE)
• Synonyms: CELLFORM(TM) POLYMER;2-HYDROXYETHYL METHACRYLATE POLYMER;POLY(2-HEMA);POLY(2-HYDROXYETHYL METHACRYLATE);POLY-HEMA;polyhydroxyethylmethacrylate;POLY(2-HYDROXYETHYL METHACRYLATE), MV CA;POLY(2-HYDROXYETHYL METHACRYLATE) CELL*C ULTURE TEST
• CAS NO: 25249-16-5
• Molecular Formula: (C6H10O3)n
• Molecular Weight: 130.14
• EINECS: 212-782-2
• Product Categories: Acrylics;and Related Polymers;Contact Printing;Ethacrylate;Hydrophilic Polymers;Materials Science;Methacrylate;Micro/NanoElectronics;Microcontact Printing;PMMA-Based Resins;Polymer Science;Polymers;Self Assembly &Stamps for Nanoprint Lithography &
• Mol File: 25249-16-5.mol
• Article Data: 36

Chemical Properties

• Boiling Point: 189°Cat760mmHg
• Flash Point: 97.2°C
• Appearance: /powder
• Density: 1.15 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.159mmHg at 25°C
• Refractive Index: 1.442
• Solubility: ethanol: 120 mg/mL
• CAS DataBase Reference: POLY(2-HYDROXYETHYL METHACRYLATE)(CAS DataBase Reference)
• NIST Chemistry Reference: POLY(2-HYDROXYETHYL METHACRYLATE)(25249-16-5)
• EPA Substance Registry System: POLY(2-HYDROXYETHYL METHACRYLATE)(25249-16-5)

Safety Data

• Safety Statements: 24/25
• WGK Germany: 3
• Hazardous Substances Data: 25249-16-5(Hazardous Substances Data)

Usage

Description

Poly(2-hydroxyethyl methacrylate), also known as pHEMA, is a versatile polymer with both hydrophilic and hydrophobic properties. It is composed of repeating 2-hydroxyethyl 2-methylpropanoate units and is characterized by non-covalent interactions of hydrogen-bonds among the polymer chains and the hydrated water molecules. The presence of polar hydroxyl and carboxyl groups on each repeat unit makes this polymer compatible with water, while the hydrophobic α-methyl groups of the backbone provide hydrolytic stability and enhance the mechanical strength of the polymer matrix.

Uses

Used in Biomedical Applications:
pHEMA is used as a nonadhesive substrate in the preparation of single cell suspensions to implant into mice cornea for corneal micropocket assays. It is also used to coat well plates for sphere assays using adipose-derived mesenchymal stem cells.
Used in Tissue Engineering:
pHEMA scaffolds are used in tissue engineering, where they can be utilized in hydrogels for biomedical applications and as sorbents for metal ions.
Used in Ophthalmology:
pHEMA has been used in the development of soft contact lenses, providing a comfortable and effective alternative to traditional hard lenses.
Used in Drug Delivery Systems:
pHEMA is employed in drug delivery systems, where it can be used to control the release of medications and improve their efficacy.
Used in Medical Devices:
pHEMA has been utilized in the production of kidney dialysis membranes, offering improved biocompatibility and performance.
Used in Controlled Drug Delivery:
Nanoparticles of pHEMA may be employed as a carrier for controlled delivery of anticancer and antitumor drugs, enhancing the therapeutic outcomes and reducing side effects.
Used in Different Industries:
In the biomedical industry, pHEMA is used as a versatile material for various applications, including tissue engineering, drug delivery systems, and medical devices.
In the ophthalmology industry, pHEMA is used in the development of soft contact lenses, providing a comfortable and effective alternative to traditional hard lenses.

Biochem/physiol Actions

Poly(2-hydroxyethyl methacrylate) is an acrylic compound and has dental usage. It is mainly used to inhibit cell adhesion to growth surfaces in culture vessels.

InChI:InChI=1/C6H10O3/c1-5(2)6(8)9-4-3-7/h7H,1,3-4H2,2H3

Upstream product

• 75-21-8 oxirane 
• 79-41-4 poly(methacrylic acid) 
• 107-21-1 ethylene glycol 
• 80-62-6 methacrylic acid methyl ester 
• 920-46-7 Methacryloyl chloride 
• 21282-97-3 2-(methacryloyloxy)ethyl acetoacetate 
• 1269794-11-7 2,2-(2-nitro-1,4-phenylene)bis(methylene)bis(oxy) bis(oxomethylene)bis(oxy)bis(ethane-2,1-diyl) bis(2-methylacrylate) 
• 20166-49-8 2-acetoxyethyl methylacrylate 
• 1279115-97-7 C₂₃H₄₅NO₁₀P₂ 
• 1279115-96-6 C₁₈H₃₅NO₁₀P₂ 
• 67-56-1 methanol 
• 1279116-12-9 C₃₁H₆₉NO₁₀P₂Si₄ 
• 1279116-11-8 C₂₆H₅₉NO₁₀P₂Si₄ 
• 2421-28-5 dianhydride of benzophenone-3,4,3',4'-tetracarboxy acid 

Downstream Products

• 102729-29-3 C₂₁H₂₀N₂O₅ 
• 1338495-88-7 1,3,5-tri(2-hydroxyethyl)isocyanurate tris-HEMA phthalate 

Relevant articles and documents

Acrylate monomer having hydrophilic end group and a method for preparing the same

More particularly, the present invention relates to an acrylate monomer having a high-purity hydrophilic terminal group which does not contain unreacted 1 water or undesirable by-products, and a method for producing the acrylate monomer. These acrylate monomers are substantially free of polymerization inhibitors. Chemical Formula 1. In Chemical Formula 1, R. 1 Chem. R. 2 Chem. R. 3 May be H, or linear, branched or cyclic C, independently of each other. 1 -C12 alkyl group. R4 Is linear, branched or cyclic C. 1 -C12 alkyl Or C1 -C12 It is alkoxy group, wherein alkyl group carbon atoms can be unsubstituted or substituted with oxygen atoms, n Is an integer selected from 1 and 10.

BIOGUM AND BOTANICAL GUM HYDROGEL BIOINKS FOR THE PHYSIOLOGICAL 3D BIOPRINTING OF TISSUE CONSTRUCTS FOR IN VITRO CULTURE AND TRANSPLANTATION

Bioink compositions comprising a biomaterial (mammalian, plant based, synthetically derived, or microbially derived) such as a hydrogel and a microbial-, fungal-, or plant-produced polysaccharide, with or without cells, for use in the 3D bioprinting of human tissues and scaffolds are described. The bioink compositions have excellent printability and improved cell function, viability and engraftment. Furthermore, the bioink compositions can be supplemented through the additional of auxiliary proteins and other molecules such as growth factors including extracellular matrix components, Laminins, super affinity growth factors and morphogens. The bioink compositions can be used under physiological conditions related to 3D bioprinting parameters which are cytocompatible (e.g. temperature, printing pressure, nozzle size, bioink gelation process). The combination of a biogum-based biomaterial together with mammalian, plant, microbial or synthetically derived hydrogels exhibited improvement in printability, cell function and viability compared to tissues printed with bioink not containing biogums.

METHOD FOR PREPARING HYDROXYETHYL (METH) ACRYLATE

Hydroxyethyl (methyl)acrylate is prepared by a process of a combination of a three-stage tubular reactor and a tower reactor, wherein, firstly, a catalyst, a polymerization inhibitor and (methyl) acrylic acid are mixed until the solids are dissolved, then mixed with a part of ethylene oxide and thereafter enter into a first tubular reactor for a reaction, a reaction liquid flowing out from the first tubular reactor is mixed with a certain amount of ethylene oxide and enters into a second tubular reactor for a reaction, a reaction liquid flowing out from the second tubular reactor is then mixed with a certain amount of ethylene oxide and thereafter enters into a third tubular reactor, and a reaction liquid flowing out from the third tubular reactor is then passed through a stage of an adiabatic tower reactor and aged such that a product liquid is obtained from extraction.