24785-38-4

Basic information

• Product Name: Benzene, 1-methoxy-4-[(4-methylphenyl)ethynyl]-
• Synonyms: 1-methoxy-4-(4'-methylphenylethynyl)benzene;1-(4-methoxyphenyl)-2-(4-methylphenyl)acetylene;1-{4-[2-(4-methylphenyl)ethynyl]phenyl}methyl ether;Benzene,1-methoxy-4-[(4-methylphenyl)ethynyl];4-[2-(4-methylphenyl)ethynyl]phenyl methyl ether;1-(2-(4-methoxyphenyl)ethynyl)-4-methylbenzene
• CAS NO: 24785-38-4
• Molecular Formula: C16H14O
• Molecular Weight: 222.287
• Mol File: 24785-38-4.mol
• Article Data: 118

Chemical Properties

• Melting Point: 125.5-126 °C
• Boiling Point: 351.5±35.0 °C(Predicted)
• Density: 1.08±0.1 g/cm3(Predicted)
• CAS DataBase Reference: Benzene, 1-methoxy-4-[(4-methylphenyl)ethynyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1-methoxy-4-[(4-methylphenyl)ethynyl]-(24785-38-4)
• EPA Substance Registry System: Benzene, 1-methoxy-4-[(4-methylphenyl)ethynyl]-(24785-38-4)

Safety Data

• Hazardous Substances Data: 24785-38-4(Hazardous Substances Data)

Upstream product

• 874988-43-9 C₁₆H₁₆Br₂O 
• 106-38-7 para-bromotoluene 
• 768-60-5 4-methoxyphenylacetylen 
• 123-11-5 4-methoxy-benzaldehyde 
• 186968-69-4 2-(Bromo-p-tolyl-methyl)-5,5-dimethyl-[1,3,2]dioxaphosphinane 2-oxide 
• 624-31-7 4-tolyl iodide 
• 696-62-8 para-iodoanisole 
• 766-97-2 4-n-methylphenylacetylene 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 3989-14-8 (4-methoxyphenylethynyl)trimethylsilane 
• 60512-57-4 1-(2,2-dibromovinyl)-4-methoxybenzene 
• 5142-75-6 tri(p-tolyl)bismuth 
• 1066-54-2 trimethylsilylacetylene 
• 33675-56-8 1-(iodoethynyl)-4-methylbenzene 

Downstream Products

• 23798-59-6 trans-1-<4-Methoxy-phenyl>-2-<4'-phenyl-stilben-4-yl>-acetylen 
• 23798-61-0 trans-1-<4-Methoxy-phenyl>-2-<4-(-2-naphthyl-(1)-aethenyl)-phenyl>-acetylen 
• 23798-60-9 trans-1-<4-Methoxy-phenyl>-2-<4-(-2-naphthyl-(2)-aethenyl)-phenyl>-acetylen 
• 53348-78-0 C₃₁H₂₄O 
• 23798-57-4 trans-1-<4-Methoxy-phenyl>-2-<4'-chlor-stilben-4-yl>-acetylen 
• 23798-58-5 trans-1-<4-Methoxy-phenyl>-2-<4'-methoxy-stilben-4-yl>-acetylen 
• 874988-47-3 1-benzyl-4-(4-methoxyphenyl)-5-(p-tolyl)-1H-1,2,3-triazole 
• 57297-25-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethanone 
• 33425-19-3 1-(4-methoxyphenyl)-2-(4-methylphenyl)ethane-1,2-dione 
• 23886-71-7 4-methoxy-4'-methylbenzophenone 
• 345617-51-8 2-(4-methoxyphenyl)-1-(4-methylphenyl)ethanone 
• 1337542-05-8 (Z)-2-iodo-1-(4-methoxyphenyl)-2-(p-tolyl)vinyl acetate 
• 1337541-93-1 (E)-2-iodo-1-(4-methoxyphenyl)-2-(p-tolyl)vinyl acetate 
• 1370552-45-6 3-bromo-5-(4-methoxyphenyl)-2-phenyl-4-(p-tolyl)furan 

Relevant articles and documents

Samarium powder-catalyzed palladium-free and ligand-free sonogashira coupling reactions

A study of samarium powder-catalyzed cross-coupling reactions of aryl halides with terminal alkynes is described. The couplings performed in the polyethylene glycol PEG-600 provided the corresponding coupling products in good yields. The first example of palladium-free, copper-free and amine-free catalytic system for Sonogashira couplings is presented in the absence of ligand.

Lipids as versatile solvents for chemical synthesis

Development of safe, renewable, cheap and versatile solvents is a longstanding challenge in chemistry. We show here that vegetable oils and related systems can become prominent solvents for organic synthesis. Suzuki-Miyaura, Hiyama, Stille, Sonogashira and Heck cross-couplings proceed with quantitative yields in a range of vegetable oils, fish oil, butter and waxes used as solvents. Appropriate methodologies for high-throughput screening and sustainable isolation techniques applicable for vegetable oils and related lipids are presented.

Selective Phosphoranation of Unactivated Alkynes with Phosphonium Cation to Achieve Isoquinoline Synthesis

We herein develop a selective phosphoranation of alkynes with phosphonium cation, which directs a concise approach to isoquinolines from unactivated alkyne and nitrile feedstocks in a single step. Mechanistic studies suggest that the annulation reaction is initiated by the unprecedented phosphoranation of alkynes, thus representing a unique reaction pattern of phosphonium salts and distinguishing it from existing protocols that largely rely on the utilization of highly functionalized imines/oximes and/or highly polarized alkynes.