24751-40-4 Usage
Description
5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid, also known as 3-methoxy-4-hydroxybenzyl ester of N-acetylneuraminic acid, is a synthetic compound derived from sialic acid, a crucial component of numerous glycoproteins and glycolipids. This unique chemical is utilized in biochemical research and drug development, offering potential therapeutic applications in treating various diseases, including cancer and viral infections. Its distinctive structural attributes make it an invaluable tool for elucidating the biological functions of sialic acids and for the development of novel drugs targeting sialic acid-related pathways.
Uses
Used in Pharmaceutical Industry:
5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid is used as a therapeutic agent for the treatment of various diseases, such as cancer and viral infections, due to its potential to target sialic acid-related pathways and modulate their effects on disease progression.
Used in Biochemical Research:
In the field of biochemical research, 5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid serves as a valuable tool for studying sialic acid metabolism and its role in cellular processes, providing insights into the fundamental biological functions of sialic acids.
Used in Drug Development:
5-N-acetyl-2-O-(3-methoxyphenyl)-alpha-D-neuraminic acid is employed as a lead compound in drug development, facilitating the discovery and design of new pharmaceuticals that can effectively target sialic acid-related pathways, potentially leading to innovative treatments for a range of diseases.
Check Digit Verification of cas no
The CAS Registry Mumber 24751-40-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,7,5 and 1 respectively; the second part has 2 digits, 4 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 24751-40:
(7*2)+(6*4)+(5*7)+(4*5)+(3*1)+(2*4)+(1*0)=104
104 % 10 = 4
So 24751-40-4 is a valid CAS Registry Number.
InChI:InChI=1/C18H25NO10/c1-9(21)19-14-12(22)7-18(17(25)26,29-16(14)15(24)13(23)8-20)28-11-5-3-4-10(6-11)27-2/h3-6,12-16,20,22-24H,7-8H2,1-2H3,(H,19,21)(H,25,26)/t12-,13+,14+,15+,16+,18+/m0/s1
24751-40-4Relevant articles and documents
PHASE-TRANSFER-CATALYZED SYNTHESIS OF ARYL α-KETOSIDES OF N-ACETYLNEURAMINIC ACID. A 2-METHYLFLUORAN-6-YL GLYCOSIDE OF N-ACETYLNEURAMINIC ACID, 2-METHYL-6-(5-ACETAMIDO-3,5-DIDEOXY-α-D-glycero-D-galacto-NONULOPYRANOSYLONIC ACID)XANTHENE-9-SPIRO-1'-ISOBENZOFURAN-3'-ONE, A NEW SUBSTRATE..
Rothermel, Joerg,Faillard, Hans
, p. 29 - 40 (2007/10/02)
Glycosidation of N-acetylneuraminic acid by phase-transfer catalysis in chloroform-aqueous alkali gave several known and some new aryl α-ketosides in a short reaction time and in good yields.The 4-methylumbelliferyl α-ketoside, the standard substrate for neuraminidase, was prepared in a yield of up to 70percent.New Neu5Ac ketosides were prepared with fluorescein and the fluorescein analog, 2-methyl-6-hydroxyfluoran (2-methyl-6-hydroxyxanthene-9-spiro-1'-isobenzofuran-3'-one) as aglycons, the latter being synthesized from 2-(2-hydroxy-5-methylbenzoyl) benzoic acid and 3-fluorophenol.The α configuration was ascertained by 400-MHz 1H-NMR spectroscopy and by cleavage of the ketosides with neuraminidases from Vibrio cholerae and Clostridium perfringens.The enzymic hydrolysis of the 2-methylfluoran-6-yl ketoside gave Km values of 82 μM (V. cholerae) and 96 μM (C. perfringens).
