246877-32-7 Usage
Description
(tert-butoxycarbonyl)-homophenylalanyl-diethylamide, also known as Boc-homophenylalanine diethylamide or Boc-Hph-DiEt, is a synthetic compound derived from phenylalanine. It has a chemical formula of C23H34N2O3 and is characterized by its white crystalline solid appearance. (tert-butoxycarbonyl)-homophenylalanyl-diethylamide is insoluble in water but soluble in organic solvents. Boc-Hph-DiEt is widely utilized in the field of peptide chemistry, particularly in solid-phase peptide synthesis, where it serves as a protective group for the amino group of homophenylalanine. This protective role prevents unwanted side reactions during the peptide chain assembly process.
Uses
Used in Peptide Chemistry:
(tert-butoxycarbonyl)-homophenylalanyl-diethylamide is used as a protective group in peptide chemistry for the amino group of homophenylalanine. The application reason is to prevent unwanted side reactions during the peptide chain assembly process, ensuring the successful synthesis of the desired peptide sequence.
Used in Pharmaceutical Research:
In the pharmaceutical industry, Boc-Hph-DiEt may be used as a building block or intermediate in the development of new drugs, particularly those targeting specific biological pathways or receptors. The application reason is its structural similarity to phenylalanine, which can be exploited to design molecules with specific biological activities.
Used in Chemical Synthesis:
(tert-butoxycarbonyl)-homophenylalanyl-diethylamide can also be employed in various chemical synthesis processes, where its unique structure and reactivity can be utilized to create a range of different compounds. The application reason is its versatility as a synthetic intermediate, allowing for the development of novel chemical entities with potential applications in various fields.
Check Digit Verification of cas no
The CAS Registry Mumber 246877-32-7 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,4,6,8,7 and 7 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 246877-32:
(8*2)+(7*4)+(6*6)+(5*8)+(4*7)+(3*7)+(2*3)+(1*2)=177
177 % 10 = 7
So 246877-32-7 is a valid CAS Registry Number.
246877-32-7Relevant articles and documents
Structure-activity relationship of HIV-1 protease inhibitors containing α-hydroxy-β-amino acids. Detailed study of P1 site
Takashiro, Eiji,Hayakawa, Ichiro,Nitta, Tamayo,Kasuya, Atsushi,Miyamoto, Shuichi,Ozawa, Yuji,Yagi, Ryuichi,Yamamoto, Ikue,Shibayama, Takahiro,Nakagawa, Akihiko,Yabe, Yuichiro
, p. 2063 - 2072 (1999)
The structure-activity relationship of HIV-1 protease (HIV-1 PR) inhibitors containing α-hydroxy-β-amino acids is discussed. We demonstrated that substituent groups on the P1 aromatic rings of the inhibitors exert significant influence on their biological activity. Inhibitors bearing an alkyl or a fluorine atom at the meta and para position on their P1 benzene ring were found to be good inhibitors. We also discovered that the substitution positions of the P2 benzamides were crucial for good antiviral potency. In this study, inhibitor 48 was the most potent {IC90 (CEM/HIV-1 IIIB) 27 nM} and showed good pharmacokinetics in rats.
