24468-13-1 Usage
Description
2-Ethylhexyl chloroformate is a colorless to light yellow colored liquid that is denser than water. It has the potential to cause irritation upon contact with skin, eyes, and mucous membranes. Additionally, it is considered toxic if ingested, inhaled, or absorbed through the skin.
Uses
Used in Pharmaceutical Industry:
2-Ethylhexyl chloroformate is used as a reagent for the synthesis of various pharmaceutical compounds due to its ability to react with different functional groups and facilitate the formation of desired products.
Used in Chemical Synthesis:
In the field of chemical synthesis, 2-Ethylhexyl chloroformate is utilized as a protecting group for alcohols, which is crucial for the selective protection of functional groups during multi-step reactions.
Used in Research and Development:
2-Ethylhexyl chloroformate is employed as a research tool in the development of new chemical processes and methodologies, particularly in the synthesis of complex organic molecules and the study of reaction mechanisms.
Used in Industrial Applications:
This chloroformate is also used in various industrial applications, such as the production of specialty chemicals, agrochemicals, and other fine chemicals, where its reactivity and selectivity are advantageous.
Air & Water Reactions
Produces corrosive toxic fumes containing HCl on contact with moist air. Decomposes in water.
Reactivity Profile
2-Ethylhexyl chloroformate is water reactive. Incompatible with strong oxidizing agents, alcohols, bases (including amines). May react vigorously or explosively if mixed with diisopropyl ether or other ethers in the presence of trace amounts of metal salts [J. Haz. Mat., 1981, 4, 291].
Health Hazard
TOXIC; inhalation, ingestion or contact (skin, eyes) with vapors, dusts or substance may cause severe injury, burns or death. Contact with molten substance may cause severe burns to skin and eyes. Reaction with water or moist air will release toxic, corrosive or flammable gases. Reaction with water may generate much heat that will increase the concentration of fumes in the air. Fire will produce irritating, corrosive and/or toxic gases. Runoff from fire control or dilution water may be corrosive and/or toxic and cause pollution.
Fire Hazard
Combustible material: may burn but does not ignite readily. Substance will react with water (some violently) releasing flammable, toxic or corrosive gases and runoff. When heated, vapors may form explosive mixtures with air: indoors, outdoors and sewers explosion hazards. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapors may travel to source of ignition and flash back. Contact with metals may evolve flammable hydrogen gas. Containers may explode when heated or if contaminated with water.
Flammability and Explosibility
Nonflammable
Check Digit Verification of cas no
The CAS Registry Mumber 24468-13-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,4,4,6 and 8 respectively; the second part has 2 digits, 1 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 24468-13:
(7*2)+(6*4)+(5*4)+(4*6)+(3*8)+(2*1)+(1*3)=111
111 % 10 = 1
So 24468-13-1 is a valid CAS Registry Number.
InChI:InChI=1/C9H17ClO2/c1-3-5-6-8(4-2)7-12-9(10)11/h8H,3-7H2,1-2H3
24468-13-1Relevant articles and documents
Design and Comparative Evaluation of the Anticonvulsant Profile, Carbonic-Anhydrate Inhibition and Teratogenicity of Novel Carbamate Derivatives of Branched Aliphatic Carboxylic Acids with 4-Aminobenzensulfonamide
Bibi, David,Mawasi, Hafiz,Nocentini, Alessio,Supuran, Claudiu T.,Wlodarczyk, Bogdan,Finnell, Richard H.,Bialer, Meir
, p. 1972 - 1982 (2017)
Epilepsy is one of the most common neurological diseases, with between 34 and 76 per 100,000 people developing epilepsy annually. Epilepsy therapy for the past 100+ years is based on the use of antiepileptic drugs (AEDs). Despite the availability of more than twenty old and new AEDs, approximately 30% of patients with epilepsy are not seizure-free with the existing medications. In addition, the clinical use of the existing AEDs is restricted by their side-effects, including the teratogenicity associated with valproic acid that restricts its use in women of child-bearing age. Thus, there is an unmet clinical need to develop new, effective AEDs. In the present study, a novel class of carbamates incorporating phenethyl or branched aliphatic chains with 6–9 carbons in their side-chain, and 4-benzenesulfonamide-carbamate moieties were synthesized and evaluated for their anticonvulsant activity, teratogenicity and carbonic anhydrase (CA) inhibition. Three of the ten newly synthesized carbamates showed anticonvulsant activity in the maximal-electroshock (MES) and 6?Hz tests in rodents. In mice, 3-methyl-2-propylpentyl(4-sulfamoylphenyl)carbamate(1), 3-methyl-pentan-2-yl-(4-sulfamoylphenyl)carbamate (9) and 3-methylpentyl, (4-sulfamoylphenyl)carbamate (10) had ED50 values of 136, 31 and 14?mg/kg (MES) and 74, 53, and 80?mg/kg (6?Hz), respectively. Compound (10) had rat-MES-ED50 = 13?mg/kg and ED50 of 59?mg/kg at the mouse-corneal-kindling test. These potent carbamates (1,9,10) induced neural tube defects only at doses markedly exceeding their anticonvuslnat-ED50 values. None of these compounds were potent inhibitors of CA IV, but inhibited CA isoforms I, II and VII. The anticonvulsant properties of these compounds and particularly compound 10 make them potential candidates for further evaluation and development as new AEDs.
