244229-34-3

Basic information

• Product Name: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one
• Synonyms: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one;2'-Bromo-2,2,2-trifluoroacetophenone;1-(2-Bromo-phenyl)-2,2,2-trifluoro-ethanone;2'-Bromo-2,2,2-trifluoroacetophenone 97%;2-Bromo-α,α,α-trifluoroacetophenone;2'-Bromo-2,2,2-trifluoroacetophenone97%
• CAS NO: 244229-34-3
• Molecular Formula: C₈H₄BrF₃O
• Molecular Weight: 253.0159696
• Mol File: 244229-34-3.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 230.0±40.0 °C(Predicted)
• Flash Point: 101℃
• Appearance: /
• Density: 1.645 g/mL at 25 °C
• Refractive Index: n20/D1.495
• BRN: 8312425
• CAS DataBase Reference: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one(244229-34-3)
• EPA Substance Registry System: 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one(244229-34-3)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 244229-34-3(Hazardous Substances Data)

Usage

Description

1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is a chemical compound that features a 2-bromophenyl group connected to a trifluoroethyl ketone group. 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is recognized for its unique structure and reactivity, which makes it a valuable intermediate in the synthesis of a wide range of organic compounds.

Uses

Used in Pharmaceutical Synthesis:
1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is utilized as a key building block in the development of pharmaceuticals. Its presence of bromine and trifluoromethyl groups enhances its reactivity and compatibility in various chemical reactions, contributing to the creation of new medicinal compounds.
Used in Agrochemical Production:
In the agrochemical industry, 1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one serves as an important intermediate. Its unique properties allow it to be incorporated into the synthesis of novel agrochemicals, potentially leading to more effective and targeted pest control solutions.
Used in Organic Synthesis:
1-(2-Bromophenyl)-2,2,2-trifluoroethan-1-one is employed as a versatile intermediate in organic synthesis across various industries. Its structural attributes and reactivity make it suitable for the production of complex organic molecules, which can be applied in a multitude of chemical and material science applications.

Upstream product

• 383-63-1 ethyl trifluoroacetate, 
• 583-53-9 2,3-dibromobenzene 
• 6630-33-7 ortho-bromobenzaldehyde 
• 394203-55-5 1-(2-bromophenyl)-2,2,2-trifluoroethanol 
• 75-46-7 trifluoromethan 
• 610-94-6 2-bromobenzoic acid methyl ester 

Downstream Products

• 244229-36-5 (S)-2,2,2-trifluoro-1-(2-bromophenyl)ethanol 
• 244229-38-7 (R)-2,2,2-trifluoro-1-(2-bromophenyl)ethanol 
• 244229-40-1 o-bromo-(S)-(2,2,2-trifluoro-1-acetoxyethyl)benzene 
• 244229-42-3 o-bromo-(R)-(2,2,2-trifluoro-1-acetoxyethyl)benzene 
• 394203-55-5 1-(2-bromophenyl)-2,2,2-trifluoroethanol 
• 1566469-90-6 (E)-1-bromo-2-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)benzene 
• 1566469-93-9 (Z)-1-bromo-2-(3,3,3-trifluoro-1-phenylprop-1-en-2-yl)benzene 

Relevant articles and documents

New approach to a novel axially chiral ligand showing spontaneous enrichment of axial chirality.

We have synthesized novel axially chiral ligand with two chiral centers, (R)-(R)(2)- and (S)-(S)(2)-2,2'-bis(2,2,2-trifluoro-1-hydroxyethyl)biphenyl (1), which showed a high asymmetric induction when used as ligand. Here, another new approach to 1 by kine

Visible light-promoted umpolung coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines

Tertiary alcohols bearing a trifluoromethyl group are of considerable medicinal interest. Using an umpolung strategy, we herein report the first intermolecular reductive cross-coupling of aryl tri-/difluoroethanones with 2-alkenylpyridines with the aid of a Br?nsted acid catalyst upon visible-light irradiation. This metal-free reaction is operationally simple and performed at ambient temperature, allowing access to desired tertiary alcohols with tri-/difluoromethyl groups in moderate to excellent yields. The commercially available and easily handled Hantzsch ester effectively serves as an electron donor, as well as a hydrogen atom source.

One-pot multistep synthesis of trisubstituted alkenes from N -tosylhydrazones and alcohols

A one-pot procedure for the synthesis of trisubstituted alkenes from N-tosylhydrazones and alcohols is reported. This procedure combines the aerobic oxidation reaction and Wittig reaction in one pot, which avoids using of environmentally toxic oxidants and isolation of the intermediates. The simple procedure makes it very attractive for the synthesis of trisubstituted alkenes when alcohols are used as starting materials. A variety of trisubstituted alkenes as well as trifluoromethyl-substituted alkenes were obtained in moderate to good yields (up to 84%) with good E-selectivity (up to 99%). Georg Thieme Verlag Stuttgart.New York.