244154-66-3

Basic information

• Product Name: BMS-946815
• Synonyms: BMS-946815;(1S)-1-(Chloromethyl)-1,2-dihydro-5-[[(4-methyl-1-piperazinyl)carbonyl]oxy]-3H-benz[e]indole-3-carboxylic acid 1,1-dimethylethyl ester;TERT-BUTYL (S)-1-(CHLOROMETHYL)-5-((4-METHYLPIPERAZINE-1-CARBONYL)OXY)-1,2-DIHYDRO-3H-BENZO[E]INDOLE-3-CARBOXYLATE
• CAS NO: 244154-66-3
• Molecular Formula: C24H30ClN3O4
• Molecular Weight: 459.9657
• Mol File: 244154-66-3.mol
• Article Data: 7

Chemical Properties

• Appearance: /
• CAS DataBase Reference: BMS-946815(CAS DataBase Reference)
• NIST Chemistry Reference: BMS-946815(244154-66-3)
• EPA Substance Registry System: BMS-946815(244154-66-3)

Safety Data

• Hazardous Substances Data: 244154-66-3(Hazardous Substances Data)

Upstream product

• 109-01-3 1-methyl-piperazine 
• 122745-41-9 tert-butyl (1S)-1-(chloromethyl)-5-hydroxy-1,2-dihydro-3H-benzo[e]indole-3-carboxylate 
• 935764-65-1 C₂₄H₂₉ClIN₃O₄ 
• 39539-66-7 4-methyl-piperazine-1-carbonyl chloride 
• 55112-42-0 4-methylpiperazine-1-carbonyl chloride monohydrochloride 
• 128300-11-8 5-(benzyloxy)-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzindole 
• 24424-99-5 di-tert-butyl dicarbonate 
• 2764-95-6 4-methoxy-2-naphthylamine 
• 501440-80-8 3-(N-tert-butyloxycarbonyl)amino-1-O-(tertbutyloxycarbonyl)-1-naphthol 
• 139975-98-7 tert-butyl-(4-hydroxynaphthalen-2-yl)carbamate 
• 122745-36-2 N-(tert-butyloxycarbonyl)-4-(benzyloxy)-2-naphthylamine 
• 161646-53-3 tert-butyl (4-(benzyloxy)-1-iodonaphthalen-2-yl)carbamate 
• 161646-54-4 2-<amino>-4-(benzyloxy)-1-iodonaphthalene 
• 161646-55-5 5-(Benzyloxy)-3-(tert-butyloxycarbonyl)-1-<<(2',2',6',6'-tetramethylpiperidino)oxy>methyl>-1,2-dihydro-3H-benzindole 

Relevant articles and documents

CBI prodrug analogs of CC-1065 and the duocarmycins

The preparation of a small series of CBI-indole2 prodrugs is detailed.

ASYMMETRIC CONJUGATE COMPOUNDS

The invention relates to compound of formula (I): A-X1-L-X2-B and salts, solvates and tautomers thereof, which are useful as medicaments, in particular as anti-proliferative agents and for use as a drug in an antibody-drug conjugate;

PEPTIDOMIMETIC COMPOUNDS AND ANTIBODY-DRUG CONJUGATES THEREOF

This invention relates to peptidomimetic linkers and anti-body drug conjugates thereof, to pharmaceutical compositions containing them, and to their use in therapy for the prevention or treatment of cancer.