24279-06-9Relevant articles and documents
Dane et al.
, p. 2755 (1970)
Ligand-Controlled Regiodivergent Pathways of Rhodium(III)-Catalyzed Dihydroisoquinolone Synthesis: Experimental and Computational Studies of Different Cyclopentadienyl Ligands
Wodrich, Matthew D.,Ye, Baihua,Gonthier, Jér?me F.,Corminboeuf, Clémence,Cramer, Nicolai
supporting information, p. 15409 - 15418 (2016/02/18)
RhIII-catalyzed directed C-H functionalizations of arylhydroxamates have become a valuable synthetic tool. To date, the regioselectivity of the insertion of the unsaturated acceptor into the common cyclometalated intermediate was dependent solely on intrinsic substrate control. Herein, we report two different catalytic systems that allow the selective formation of regioisomeric 3-aryl dihydroisoquinolones and previously inaccessible 4-aryl dihydroisoquinolones under full catalyst control. The differences in the catalysts are computationally examined using density functional theory and transition state theory of different possible pathways to elucidate key contributing factors leading to the regioisomeric products. The stabilities of the initially formed rhodium complex styrene adducts, as well as activation barrier differences for the migratory insertion, were identified as key contributing factors for the regiodivergent pathways. RhIII-catalyzed directed C-H functionalization of aryl hydroxamates enables the selective formation of regioisomeric 3-aryl or 4-aryl dihydroisoquinolones with two different catalytic systems. The different selectivities are examined using DFT and transition state theory. The stabilities of the rhodium complex adducts and migratory-insertion activation barriers are key factors for the regiodivergent pathways (see scheme; rs=regioselectivity).
Synthesis and properties of novel substituted 4,5,6,7-tetrahydroindenes and selected metal complexes
Austin, Rachel N.,Clark, T. Jeffrey,Dickson, Thomas E.,Killian, Christopher M.,Nile, Terence A.,et al.
, p. 11 - 18 (2007/10/02)
The synthesis of a complete series of substituted 4,5,6,7-tetrahydroindenes (4,5,6,7-tetrahydroindene, 1; 1-methyl-, 1,3-dimethyl- and 1,2,3-trimethyl-4,5,6,7-tetrahydroindene, 2-4) is reported.The synthesis of ferrocenes (8-11) from these substituted cyclopentadienes is described.The electrochemistry of these ferrocenes indicates that these complexes are more readily oxidized than ferrocene and that the effect of methyl or alkyl substituents on the ease of oxidation is additive.A single crystal X-ray structure of two of the ferrocenes, bis(1,3-dimethyl-4,5,6,7-tetrahydroindenyl)iron(II), 10, and bis(1,2,3-trimethyl-4,5,6,7-tetrahydroindenyl)iron(II), 11, indicates that steric hindrance causes the alkyl substituents to be bent away from the plane of the cyclopentadienyl ring.However, the structures differ in that the cyclopentadienyl rings in 10 are staggered whereas those in 11 are eclipsed.The synthesis of the cyclopentadienyltricarbonylmethyl compounds of molybdenum and tungsten from 3 and 4 is also described.Keywords: Iron; Molybdenum; Tungsten; Indenes; Metallocenes; Electrochemistry