24255-31-0Relevant articles and documents
Synthesis of 2-Alkylaminoquinolines and 1,8-Naphthyridines by Successive Ruthenium-Catalyzed Dehydrogenative Annulation and N-Alkylation Processes
Lv, Wan,Xiong, Biao,Jiang, Huanfeng,Zhang, Min
, p. 1202 - 1207 (2017)
A new one-pot synthetic protocol, enabling the facile access to 2-alkylaminoquinolines and 1,8-naphthyridines by successive ruthenium-catalyzed dehydrogenative annulation and N-alkylation processes, has been demonstrated. A series of 2-aminoarylmethanols were efficiently converted in combination with different types of nitriles and alcohols into various desired products in moderate to excellent yields after isolation. Advantageously, the synthesis proceeds with high atom-efficiency, broad substrate scope, operational simplicity, no need for external hydrogen sources and less environmentally benign halogenated reagents, thus offering a practical approach to access these two types of compounds that are currently difficult to prepare with the conventional methods. (Figure presented.).
N -Alkylation of organonitrogen compounds catalyzed by methylene-linked bis-NHC half-sandwich ruthenium complexes
Botubol-Ares, José Manuel,Collado, Isidro G.,Jiménez-Tenorio, Manuel,Moutaoukil, Zakaria,Serrano-Díez, Emmanuel
supporting information, p. 831 - 839 (2022/02/03)
An efficient ruthenium-catalyzed N-alkylation of amines, amides and sulfonamides has been developed employing novel pentamethylcyclopentadienylruthenium(ii) complexes bearing the methylene linked bis(NHC) ligand bis(3-methylimidazol-2-ylidene)methane. The
A Borrowing Hydrogen Strategy for Dehydrative Coupling of Aminoisoquinolines with Benzyl Alcohols in Water
Hikawa, Hidemasa,Tan, Rie,Tazawa, Aoi,Kikkawa, Shoko,Azumaya, Isao
supporting information, p. 539 - 547 (2020/01/02)
We report a borrowing hydrogen strategy for a palladium-catalyzed dehydrative coupling of aminoisoquinolines with benzylic alcohols in water. This cascade reaction using the π-benzylpalladium system can be achieved in an atom-economic process without the