24201-13-6

Basic information

• Product Name: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid
• Synonyms: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid;4-ACETAMIDO-5-CHLORO-O-ANISIC ACID;4-ACETAMIDO-5-CHLORO-2-METHOXYBENZOIC ACID,95% MIN(HPLC);4-Acetamido-5-chloro-2-methoxybenzoic acid;4-Acetamino-5-chloro-2-methoxybenzoic acid
• CAS NO: 24201-13-6
• Molecular Formula: C₁₀H₁₀ClNO₄
• Molecular Weight: 243.6437
• Mol File: 24201-13-6.mol
• Article Data: 13

Chemical Properties

• Melting Point: 188 ºC
• Boiling Point: 454.615 °C at 760 mmHg
• Flash Point: 228.743 °C
• Appearance: /
• Density: 1.424
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.607
• PKA: 3.79±0.10(Predicted)
• CAS DataBase Reference: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid(24201-13-6)
• EPA Substance Registry System: 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid(24201-13-6)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 24201-13-6(Hazardous Substances Data)

Usage

Description

4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid is a chemical compound with the molecular formula C10H10ClNO4, derived from salicylic acid. It features an acetamino group, a chlorine atom, and a methoxy group attached to a benzoic acid backbone, making it a versatile and important building block in organic chemistry. Its unique molecular structure and properties also make it a valuable tool for drug discovery and development, with potential medical applications as an anti-inflammatory and analgesic agent.

Uses

Used in Pharmaceutical Industry:
4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid is used as an intermediate in the synthesis of pharmaceuticals for its potential medical applications as an anti-inflammatory and analgesic agent. Its unique molecular structure allows for the development of new drugs with improved efficacy and reduced side effects.
Used in Agrochemical Industry:
4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid is also used as an intermediate in the synthesis of agrochemicals, contributing to the development of new pesticides and herbicides with enhanced performance and selectivity.
Used in Drug Discovery and Development:
Due to its versatile chemical structure, 4-Acetamino-5-Chloro-2-Methoxyl Benzoic Acid serves as a valuable building block in drug discovery and development. It can be modified and combined with other chemical entities to create novel compounds with potential therapeutic applications.

InChI:InChI=1/C10H10ClNO4/c1-5(13)12-8-4-9(16-2)6(10(14)15)3-7(8)11/h3-4H,1-2H3,(H,12,13)(H,14,15)

Upstream product

• 4093-31-6 methyl 2-methoxy 4-acetamido 5-chloro benzoate 

Downstream Products

• 134202-57-6 4-Amino-5-chloro-N-(1S,7aS)-hexahydro-pyrrolizin-1-yl-2-methoxy-benzamide 
• 134202-57-6 4-Amino-5-chloro-N-(1S,7aR)-hexahydro-pyrrolizin-1-yl-2-methoxy-benzamide 
• 141197-00-4 4-Amino-5-chloro-N-[(1R,7aR)-1-(hexahydro-pyrrolizin-1-yl)methyl]-2-methoxy-benzamide 
• 141196-99-8 4-amino-5-chloro-N-[(hexahydro-1H-pyrrolizin-1-yl)methyl]-2-methoxybenzamide 
• 134202-44-1 4-Amino-5-chloro-N-[(1R,7aS)-1-(hexahydro-pyrrolizin-1-yl)methyl]-2-methoxy-benzamide 
• 134202-44-1 4-amino-5-chloro-N-[exo-(hexahydro-1H-pyrrolizin-1-yl)-methyl]-2-methoxybenzamide 
• 4516-32-9 4-acetylamino-5-chloro-2-methoxy-benzoyl chloride 
• 55-21-0 benzamide 
• 171804-67-4 4-(Acetylamino)-5-chloro-N-(hexahydro-2,6-methano-1H-pyrrolizin-8-ylmethyl)-2-methoxybenzamide, hydrochloride 
• 65504-30-5 4-acetylamino-5-chloro-2-methoxy-N-[4-ethyl-1-piperazinyl]benzamide 
• 65504-21-4 4-amino-5-chloro-N-(4-ethyl-piperazin-1-yl)-2-methoxy-benzamide 
• 78991-40-9 4-amino-5-chloro-2-methoxy-N-[4-(3-thenyl)-1-piperazinyl]-benzamide 
• 56594-05-9 N-ethyl-2-(2-methoxy-4-amino-5-chloro benzamido methyl)-3-azabicyclo(3,3,0) octane 
• 70181-03-2 4-Amino-5-chloro-2-methoxy-N-(1.2-diethyl-4-pyrazolidinyl)benzamide 

Relevant articles and documents

Synthesis

The present invention provides an improved process for the production of [(±)-endo]-4-amino-5-chloro-2-methoxy-N-(1-azabicyclo[3.3.1]non-4-yl)benzamide hydrochloride, compositions thereof, and intermediates thereto.

NF-KB ACTIVATION INHIBITORS

A medicament having inhibitory activity against NF-κB activation which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to ―CONH― group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula ―O―A wherein A has the same meaning as that defined above and the group represented by formula ― CONH―E wherein E has the same meaning as that defined above.

REMEDIES FOR NEURODEGENERATIVE DISEASES

A medicament for preventive and/or therapeutic treatment of neurodegenerative diseases such as Alzheimer's disease or the like which comprises as an active ingredient a substance selected from the group consisting of a compound represented by the following general formula (I) and a pharmacologically acceptable salt thereof, and a hydrate thereof and a solvate thereof: wherein A represents hydrogen atom or acetyl group, E represents a 2,5-di-substituted or a 3,5-di-substituted phenyl group, or a monocyclic or a fused polycyclic heteroaryl group which may be substituted, provided that the compound wherein said heteroaryl group is 1○ a fused polycyclic heteroaryl group wherein the ring which binds directly to -CONH- group in the formula (I) is a benzene ring, 2○ unsubstituted thiazol-2-yl group, or 3○ unsubstituted benzothiazol-2-yl group is excluded, ring Z represents an arene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above, or a heteroarene which may have one or more substituents in addition to the group represented by formula -O-A wherein A has the same meaning as that defined above and the group represented by formula -CONH-E wherein E has the same meaning as that defined above.