2380-86-1 Usage
Description
6-Hydroxyindole is a white to off-white shiny crystalline powder that serves as a versatile reactant in the synthesis of various compounds with potential applications in the pharmaceutical and chemical industries.
Uses
Used in Pharmaceutical Industry:
6-Hydroxyindole is used as a reactant for the preparation of tryptophan dioxygenase inhibitors, pyridyl-ethenyl-indoles, which have potential as anticancer immunomodulators. It is also used as a reactant for the asymmetrical synthesis of notoamide J, a potential biosynthetic precursor of prenylated indole alkaloids.
Used in Antituberculosis Applications:
In the field of antituberculosis drug development, 6-Hydroxyindole is utilized as a reactant for the preparation of (quinolinyloxymethyl)isoxazolecarboxylate esters, which are potential antituberculosis agents.
Used in HIV Treatment:
6-Hydroxyindole is employed as a reactant for the preparation of indolyl(propanolamine) derivatives, which have potential as HIV inhibitors, contributing to the development of treatments for HIV/AIDS.
Used in Peroxisome Proliferator-Activated Receptor Agonists:
It is also used as a reactant for the preparation of indoleoxyacetic acid derivatives, which act as peroxisome proliferator-activated receptor agonists, playing a role in the regulation of cellular processes and potential therapeutic applications.
Used in Antitumor Applications:
6-Hydroxyindole is used as a reactant for the preparation of 1-aroylindole 3-aroylindoles, which are combretastatin A-4 analogs. These compounds have potential as antitumor agents and tubulin polymerization inhibitors, contributing to the development of cancer treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 2380-86-1 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,3,8 and 0 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2380-86:
(6*2)+(5*3)+(4*8)+(3*0)+(2*8)+(1*6)=81
81 % 10 = 1
So 2380-86-1 is a valid CAS Registry Number.
InChI:InChI=1/C8H5Cl2N/c9-6-3-5-1-2-11-8(5)7(10)4-6/h1-4,11H
2380-86-1Relevant articles and documents
Development of large-scale preparations of indole derivatives: Evaluation of potential thermal hazards and studies of reaction kinetics and mechanisms
Akao, Atsushi,Nonoyama, Nobuaki,Mase, Toshiaki,Yasuda, Nobuyoshi
, p. 1178 - 1183 (2012/12/23)
Hydrogenation of (E)-2-nitropyrrolidinostyrene in the presence of the doped rhodium catalyst is safe, scalable, and highly effective for the preparation of 6-benzyloxyindole. Reaction kinetics with/without additives also were examined using in situ IR for
PROCESS FOR PRODUCING INDOLOPYRROLOCARBAZOLE DERIVATIVE
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Page/Page column 39-40, (2010/02/11)
The present invention provides a process for industrially advantageously producing a compound represented by the formula (I): or a pharmaceutically acceptable salt thereof, which is useful as an anticancer agent, and also provides a catalyst used for hydrogenation reaction in the process.
HYDROXYLATION OF INDOLINES AND INDOLES BY HYDROGEN PEROXIDE IN SUPERACIDS
Berrier, Christian,Jacquesy, Jean-Claude,Jouannetaud, Marie-Paule,Renoux, Alain
, p. 4565 - 4568 (2007/10/02)
In SbF5-HF, indolines and indoles are hydroxylated on the aromatic ring, protonated hydrogen peroxide H3O2+ reacting on the protonated substrates.
