23687-26-5

Basic information

• Product Name: 6-AMINOISOQUINOLINE
• Synonyms: 6-AMINOISOQUINOLINE;6-aminoisoquanoline;6-Isoquinolinamine;Isoquinoline-6-amine;Isoquinolin-6-ylamine;Isoquinolin-6-amine, 6-Amino-2-azanaphthalene;Isoquinoline,6-amino- (7CI,8CI)
• CAS NO: 23687-26-5
• Molecular Formula: C₉H₈N₂
• Molecular Weight: 144.17
• EINECS: -0
• Product Categories: Building Blocks;Isoquinoline
• Mol File: 23687-26-5.mol
• Article Data: 10

Chemical Properties

• Melting Point: 211-212 °C(Solv: benzene (71-43-2))
• Boiling Point: 343.1 °C at 760 mmHg
• Flash Point: 188.1 °C
• Appearance: /
• Density: 1.21 g/cm³
• Vapor Pressure: 7.2E-05mmHg at 25°C
• Refractive Index: 1.708
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 7.10±0.10(Predicted)
• CAS DataBase Reference: 6-AMINOISOQUINOLINE(CAS DataBase Reference)
• NIST Chemistry Reference: 6-AMINOISOQUINOLINE(23687-26-5)
• EPA Substance Registry System: 6-AMINOISOQUINOLINE(23687-26-5)

Safety Data

• Hazard Codes: Xn
• Statements: 22-36
• Safety Statements: 26
• Hazardous Substances Data: 23687-26-5(Hazardous Substances Data)

Usage

Description

6-Aminoisoquinoline is an organic compound with the molecular formula C9H8N2. It is a heterocyclic compound featuring a quinoline ring with an amino group at the 6th position. 6-Aminoisoquinoline serves as a key intermediate in the synthesis of various pharmaceuticals and chemical compounds due to its unique structure and reactivity.

Uses

Used in Pharmaceutical Industry:
6-Aminoisoquinoline is used as a reactant for the preparation of N-[2-(4-methylpiperidin-1-yl)-6-(trifluoromethyl)-pyridin-3-ylmethyl] N''-(6,6-fused heterocyclic) ureas. These compounds are highly potent TRPV1 antagonists, which are valuable in the development of medications targeting pain relief and other conditions associated with the transient receptor potential vanilloid 1 (TRPV1) receptor. The antagonistic action on TRPV1 can help in managing pain, inflammation, and thermal hyperalgesia.

InChI:InChI=1/C9H8N2/c10-9-2-1-8-6-11-4-3-7(8)5-9/h1-6H,10H2

Upstream product

• 7651-82-3 isoquinolin-6-ol 
• 70538-57-7 6-nitroisoquinoline 
• 52962-35-3 2-(1,3-diethoxy-1,3-dioxopropan-2-yl)-4-nitrobenzoic acid 
• 99-60-5 2-chloro-4-nitrobenzoic acid 
• 39585-32-5 2-carboxymethyl-4-nitro-benzoic acid 
• 1082674-24-5 6-(bromoisoquinoline-1-carbonitrile) 
• 76144-87-1 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl 
• 34784-05-9 6-bromo-isoquinoline 
• 1336-21-6 ammonium hydroxide 
• 91-21-4 1,2,3,4-tetrahydroisoquinoline 

Downstream Products

• 107322-01-0 isoquinoline-6-sulfonyl chloride 

Relevant articles and documents

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Methods for the preparation of 6-aminoisoquinoline

Described are methods for the preparation of 6-aminoisoquinoline, a useful intermediate compound in the synthesis of kinase inhibitors.

NOVEL SELECTIVE ANDROGEN RECEPTOR MODULATORS

The present invention relates to a compound of Formula 1, 2 or 3: wherein A is N or —CR0—, where R0 is hydrogen, C1-C6 linear or branched chain alkyl, etc., Z is —CRe—, or, —N—, where Re is hydrogen, C1-C6 linear or branched chain alkyl,etc.; R1 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R2 are independently hydrogen or C1-C6 linear or branched chain alkyl; R3 and R4 are independently hydrogen, C1-C6 linear or branched chain alkyl, etc.;. R5 and R6 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; R8 is hydrogen, C1-C6 linear or branched chain alkyl, etc.; R9 and R10 are independently hydrogen or C1-C6 linear or branched chain alkyl, etc.; Q is —CO—, —(CH2)q—, —(CHRs)q—, or (CRsRt)q—, where Rs and Rt are independently C1-C6 linear or branched chain alkyl, aryl, alkylaryl, heteroaryl or alkylheteroaryl; where q is 0, 1, 2, or 3; and, where n is 0, 1, 2, 3, 4 or 5; or, a pharmaceutically acceptable salt thereof, to compositions containing such compounds; and to the uses of such compounds in the treatment of various diseases, particularly, those affected or mediated by the androgen receptor.