23438-61-1

Basic information

• Product Name: 2-Piperidinone, 1-[(4-methylphenyl)sulfonyl]-
• CAS NO: 23438-61-1
• Molecular Formula: C12H15NO3S
• Molecular Weight: 253.322
• Mol File: 23438-61-1.mol
• Article Data: 27

Chemical Properties

• CAS DataBase Reference: 2-Piperidinone, 1-[(4-methylphenyl)sulfonyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Piperidinone, 1-[(4-methylphenyl)sulfonyl]-(23438-61-1)
• EPA Substance Registry System: 2-Piperidinone, 1-[(4-methylphenyl)sulfonyl]-(23438-61-1)

Safety Data

• Hazardous Substances Data: 23438-61-1(Hazardous Substances Data)

Upstream product

• 89896-39-9 ethyl 5-azidovalerate 
• 98-59-9 p-toluenesulfonyl chloride 
• 5693-62-9 2,3,4,5-tetrahydro-6-methoxypyridine 
• 55456-48-9 ((2S)-1-p-toluenesulfonyl-2-pyrrolidinyl)methanol 
• 2508-29-4 5-hydroxypentylamine 
• 16780-44-2 N-(5-hydroxy-pentyl)-4-methyl-benzenesulfonamide 
• 101250-69-5 (S)-1-<(4-methylphenyl)sulfonyl>-2-pyrrolidinecarboxaldehyde 
• 675-20-7 piperidin-2-one 
• 52533-88-7 5-bromo-N-tosylpentanamide 
• 2042-45-7 5-(4-methylphenylsulfonamido)pentanoic acid 

Downstream Products

• 960059-43-2 C₂₄H₂₄NO₄PS 
• 67488-65-7 (RS)-1-(toluene-4-sulfonyl)-pyrrolidine-2-carboxylic acid methyl ester 
• 16814-85-0 N-tosyl proline ethyl ester 
• 626232-87-9 trifluoromethanesulfonic acid 4-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl ester 
• 757191-75-6 1-[4-isopropyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]cyclobutanol 
• 646996-64-7 1-[4-methyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]cyclobutanol 
• 757191-69-8 4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl trifluoromethanesulfonate 
• 353248-32-5 1-[4-phenyl-1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]cyclobutanol 
• 353248-22-3 1-[1-(toluene-4-sulfonyl)-1,4,5,6-tetrahydropyridin-2-yl]-cyclobutanol 
• 353248-34-7 4-phenyl-1-(toluene-4-sulfonyl)-piperidin-2-one 
• 96013-56-8 4-methyl-1-(toluene-4-sulfonyl)-piperidin-2-one 
• 81097-36-1 1-(toluene-4-sulfonyl)-1,2,3,4-tetrahydropyridine 

Relevant articles and documents

N -Tosyl-3-azacyclohexyne. Synthesis and chemistry of a strained cyclic ynamide

The first synthesis of a strained six-membered cyclic ynamide is described. N-Tosyl-3-azacyclohexyne is generated via fluoride-promoted 1,2 elimination under conditions that allow trapping of the strained heterocyclic alkyne in a variety of addition, insertion, and [2 + 2], [3 + 2], and [4 + 2] cycloaddition reactions.

Transamidation for the Synthesis of Primary Amides at Room Temperature

Various primary amides have been synthesized using the transamidation of various tertiary amides under metal-free and mild reaction conditions. When (NH4)2CO3 reacts with a tertiary amide bearing an N-electron-withdrawing substituent, such as sulfonyl and diacyl, in DMSO at 25 °C, the desired primary amide product is formed in good yield with good funcctional group tolerance. In addition, N-tosylated lactam derivatives afforded their corresponding N-tosylamido alkyl amide products via a ring opening reaction.

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

Synthesis of aminopyrazoles from sydnones and ynamides

Aminopyrazoles are prepared from readily accessible sydnones and sulfonyl ynamides using either a copper-mediated sydnone alkyne cycloaddition (CuSAC) or in situ generated strained cyclic ynamides.