22966-17-2

Basic information

• Product Name: Benzonitrile, 4-[(1E)-3-oxo-3-phenyl-1-propenyl]-
• CAS NO: 22966-17-2
• Molecular Formula: C16H11NO
• Molecular Weight: 233.269
• Mol File: 22966-17-2.mol
• Article Data: 45

Chemical Properties

• CAS DataBase Reference: Benzonitrile, 4-[(1E)-3-oxo-3-phenyl-1-propenyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzonitrile, 4-[(1E)-3-oxo-3-phenyl-1-propenyl]-(22966-17-2)
• EPA Substance Registry System: Benzonitrile, 4-[(1E)-3-oxo-3-phenyl-1-propenyl]-(22966-17-2)

Safety Data

• Hazardous Substances Data: 22966-17-2(Hazardous Substances Data)

Upstream product

• 98-86-2 acetophenone 
• 105-07-7 4-cyanobenzaldehyde 
• 98-85-1 1-Phenylethanol 
• 874-89-5 4-Cyanobenzyl alcohol 
• 623-00-7 4-bromobenzenecarbonitrile 
• 4187-87-5 1-Phenyl-2-propyn-1-ol 
• 100-52-7 benzaldehyde 
• 583-06-2 3-benzoylacrylic acid 
• 536-74-3 phenylacetylene 
• 3058-39-7 4-iodobenzonitrile 
• 936-59-4 3-chloropropiophenone 
• 350015-18-8 4-(3-oxo-3-phenylprop-1-yn-1-yl)benzonitrile 
• 3032-92-6 4-cyanophenylacetylene 
• 98-88-4 benzoyl chloride 

Downstream Products

• 98258-72-1 (E)-methyl 4-(3-oxo-3-phenylprop-1-en-1-yl)benzoate 
• 86864-14-4 3-(p-cyanophenyl)-4,4-bis(phenylthio)-1,4-diphenyl-1-butanone 
• 59824-24-7 1-phenyl-3-(p-cyanophenyl)-1-propanone 
• 193205-46-8 3-(4-cyano)phenyl-3-morpholino-1-phenylpropan-1-one 
• 1186044-33-6 diisopropyl 2-(1-(4-cyanophenyl)-3-oxo-3-phenylpropyl)malonate 
• 1221402-57-8 4-{(S)-3-oxo-1-[(R)-2-oxocyclopentyl]-3-phenylpropyl}benzonitrile 
• 1266096-08-5 (R)-tert-butyl 2-oxo-5-((S)-1-(4-cyanophenyl)-3-oxo-3-phenylpropyl)-2,5-dihydro-1H-pyrrole-1-carboxylate 
• 1292816-43-3 C₂₁H₁₃NOS 
• 1292816-40-0 4-(2-(3-chlorophenyl)-5-phenylfuran-3-yl)benzonitrile 
• 1292816-41-1 4-(2-(2-chlorophenyl)-5-phenylfuran-3-yl)benzonitrile 
• 1292816-39-7 4-(5-phenyl-2-p-tolylfuran-3-yl)benzonitrile 

Relevant articles and documents

Borane-Catalyzed, Chemoselective Reduction and Hydrofunctionalization of Enones Enabled by B-O Transborylation

The use of stoichiometric organoborane reductants in organic synthesis is well established. Here these reagents have been rendered catalytic through an isodesmic B-O/B-H transborylation applied in the borane-catalyzed, chemoselective alkene reduction and formal hydrofunctionalization of enones. The reaction was found to proceed by a 1,4-hydroboration of the enone and B-O/B-H transborylation with HBpin, enabling catalyst turnover. Single-turnover and isotopic labeling experiments supported the proposed mechanism of catalysis with 1,4-hydroboration and B-O/B-H transborylation as key steps.

Microwave-assisted synthesis of novel pyrazole derivatives and their biological evaluation as anti-bacterial agents

Aims and Objectives: Microwave-assisted condensation of acetophenone 1 and aromatic aldehydes 2 gave chalcone analogs 3, which were cyclized to pyrazole derivatives 6a-f via the reaction with hydrazine hydrate and oxalic acid in the presence of the catalytic amount of acetic acid in ethanol. Materials and Methods: The structural features of the synthesized compounds were characterized by melting point, FT-IR,1H,13C NMR and elemental analysis. Results: The antibacterial activities of the synthesized pyrazoles were evaluated against three gram-positive bacteria, such as Enterococcus durans, Staphylococcus aureus, Bacillus subtilis and two gram-negative bacteria such as Escherichia coli and Salmonella typhimurium. Conclusion: All the synthesized pyrazoles showed relatively high antibacterial activity against S. aureus strain, and none of them demonstrated antibacterial activity against E. coli.

Gold-catalyzed partial hydrogenation of activated alkynes mediated by triphenylphosphine

Gold(I) can exhibit a cooperative effect with triphenylphosphine, accelerating the triphenylphosphine-mediated partial hydrogenation of activated alkynes. In this protocol, 3-arylpropiolates are selectively reduced to the Z -isomer when the aryl ring bears an electron-donor substituent, whereas 3-arylpropynones are reduced to the E-isomers.