227626-61-1Relevant articles and documents
Oxadiazolone bioisosteres of pregabalin and gabapentin
Wustrow, David J.,Belliotti, Thomas R.,Capiris, Thomas,Kneen, Clare O.,Bryans, Justin S.,Field, Mark J.,Williams, Dic,El-Kattan, Ayman,Buchholz, Lisa,Kinsora, Jack J.,Lotarski, Susan M.,Vartanian, Mark G.,Taylor, Charles P.,Donevan, Sean D.,Thorpe, Andrew J.,Schwarz, Jacob B.
scheme or table, p. 247 - 250 (2009/05/26)
A series of oxadiazolone bioisosteres of pregabalin 1 and gabapentin 2 were prepared, and several were found to exhibit similar potency for the α2-δ subunit of voltage-gated calcium channels. Oxadiazolone 9 derived from 2 achieved low brain upt
Method of treating tinnitus
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, (2008/06/13)
The invention relates to a method of treating tinnitus by administering an alpha2delta ligand such as, for example, a compound of Formula and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.
Method of treating cartilage damage
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, (2008/06/13)
The invention relates to a method of preventing or treating cartilage damage by administering a GABA analog such as, for example, a compound of Formula 1and pharmaceutically acceptable salts thereof, wherein R1 is hydrogen or straight or branched lower alkyl, and n is an integer of from 4 to 6.