22525-43-5 Usage
Description
4-AMINO-4'-(N,N-DIMETHYLAMINO)STILBENE, also known as DASB, is a chemical compound that serves as a serotonin transporter ligand. It is a fluorescent dye with high affinity for serotonin transporters, making it a valuable tool in neuroimaging studies for visualizing the location and activity of these transporters in the brain. DASB's fluorescent properties allow for the study of the distribution and function of serotonin transporters in the central nervous system, and it is also utilized in the development and evaluation of pharmaceuticals targeting serotonin-related disorders.
Uses
Used in Neuroimaging Studies:
4-AMINO-4'-(N,N-DIMETHYLAMINO)STILBENE is used as a fluorescent dye for visualizing the location and activity of serotonin transporters in the brain. Its high affinity for these transporters makes it a valuable tool for studying various neurological conditions, such as depression, anxiety, and Parkinson's disease.
Used in Pharmaceutical Development:
4-AMINO-4'-(N,N-DIMETHYLAMINO)STILBENE is used as a research compound in the development and evaluation of potential pharmaceuticals to treat serotonin-related disorders. Its ability to bind with high affinity to serotonin transporters aids in understanding the mechanisms of action and efficacy of these potential treatments.
Used in Scientific Research:
4-AMINO-4'-(N,N-DIMETHYLAMINO)STILBENE is used as a research tool in various scientific studies to investigate the role of serotonin transporters in the central nervous system. Its fluorescent properties enable researchers to explore the distribution and function of these transporters, contributing to a better understanding of the underlying mechanisms of neurological conditions and the development of targeted therapies.
Check Digit Verification of cas no
The CAS Registry Mumber 22525-43-5 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,2,5,2 and 5 respectively; the second part has 2 digits, 4 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 22525-43:
(7*2)+(6*2)+(5*5)+(4*2)+(3*5)+(2*4)+(1*3)=85
85 % 10 = 5
So 22525-43-5 is a valid CAS Registry Number.
22525-43-5Relevant articles and documents
Copper Bis(thiosemicarbazonato)-stilbenyl Complexes That Bind to Amyloid-β Plaques
Cullinane, Carleen,Donnelly, Paul S.,Hayne, David J.,Lim, SinChun,McLean, Catriona A.,Noor, Asif,Roselt, Peter D.,Van Zuylekom, Jessica K.,White, Jonathan M.
, p. 11658 - 11669 (2020/08/24)
Alzheimer's disease is characterized by the presence of extracellular amyloid-β plaques. Positron emission tomography (PET) imaging with tracers radiolabeled with positron-emitting radionuclides that bind to amyloid-β plaques can assist in the diagnosis o
Theoretical and Experimental Studies of N,N-Dimethyl-N′-Picryl-4,4′-Stilbenediamine
Papper, Vladislav,Wu, Yuanyuan,Kharlanov, Vladimir,Sukharaharja, Ayrine,Steele, Terry W. J.,Marks, Robert S.
, p. 13 - 19 (2015/02/19)
N,N-dimethyl-N′-picryl-4,4′-stilbenediamine (DMPSDA) was prepared, purified and crystallised in a form of black lustrous crystals, and its absorption and fluorescence spectra were recorded in cyclohexane, acetonitrile and dimethyl sulfoxide. Non-emissive
Rhenium(i) complexes of N-heterocyclic carbene ligands that bind to amyloid plaques of Alzheimer's disease
Chan, Chung Ying,Noor, Asif,McLean, Catriona A.,Donnelly, Paul S.,Barnard, Peter J.
supporting information, p. 2311 - 2314 (2017/02/23)
A series of [Re(i)L(CO)3]+ complexes (where L is a bifunctional bis(NHC)-amine ligand) that are analogues of potential Tc-99m diagnostic imaging agents for Alzheimer's disease have been synthesised. One of the complexes bound to amyl
