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225120-65-0

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225120-65-0 Usage

Description

Cathepsin Inhibitor 1 is a chemical compound specifically designed to inhibit the activity of cathepsin enzymes, including cathepsin B, L, and S. These proteases play a crucial role in physiological and pathological processes such as protein degradation, antigen presentation, and tumor invasion. By effectively blocking the activity of these enzymes, Cathepsin Inhibitor 1 has the potential to modulate these processes and is currently being explored as a promising therapeutic agent for a range of diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. Ongoing research is focused on understanding the effects of Cathepsin Inhibitor 1 on cathepsin activity and its implications for disease treatment and therapy development.

Uses

Used in Pharmaceutical Industry:
Cathepsin Inhibitor 1 is used as a therapeutic agent for the treatment of various diseases, including cancer, autoimmune disorders, and neurodegenerative diseases. Its ability to inhibit cathepsin enzymes modulates key processes involved in these diseases, offering a potential avenue for new treatment options.
Used in Cancer Therapy:
Cathepsin Inhibitor 1 is used as an anticancer agent, targeting the proteolytic activity of cathepsins that facilitate tumor invasion and metastasis. By inhibiting these enzymes, Cathepsin Inhibitor 1 can potentially limit the progression of cancer and improve patient outcomes.
Used in Autoimmune Disorder Treatment:
Cathepsin Inhibitor 1 is used as a treatment for autoimmune disorders, where the inhibition of cathepsin enzymes can help regulate the immune response and reduce inflammation, thereby alleviating symptoms and managing the disease.
Used in Neurodegenerative Disease Management:
Cathepsin Inhibitor 1 is used in the management of neurodegenerative diseases, where the inhibition of cathepsin enzymes may help slow down the progression of neurodegeneration by modulating protein degradation and aggregation processes.
Used in Research Applications:
Cathepsin Inhibitor 1 is used as a research tool to study the role of cathepsin enzymes in various biological processes and disease mechanisms. This helps in understanding the underlying pathways and developing targeted therapies for different conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 225120-65-0 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 2,2,5,1,2 and 0 respectively; the second part has 2 digits, 6 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 225120-65:
(8*2)+(7*2)+(6*5)+(5*1)+(4*2)+(3*0)+(2*6)+(1*5)=90
90 % 10 = 0
So 225120-65-0 is a valid CAS Registry Number.

225120-65-0SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 3-Chloro-N-(cyanomethyl)-Nα-{[1-methyl-3-(2-methyl-2-propanyl)-1H -pyrazol-5-yl]carbonyl}-L-phenylalaninamide

1.2 Other means of identification

Product number -
Other names Cathepsin Inhibitor 1

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:225120-65-0 SDS

225120-65-0Upstream product

225120-65-0Downstream Products

225120-65-0Relevant articles and documents

Dipeptidyl nitrile inhibitors of Cathepsin L

Asaad, Nabil,Bethel, Paul A.,Coulson, Michelle D.,Dawson, Jack E.,Ford, Susannah J.,Gerhardt, Stefan,Grist, Matthew,Hamlin, Gordon A.,James, Michael J.,Jones, Emma V.,Karoutchi, Galith I.,Kenny, Peter W.,Morley, Andrew D.,Oldham, Keith,Rankine, Neil,Ryan, David,Wells, Stuart L.,Wood, Linda,Augustin, Martin,Krapp, Stephan,Simader, Hannes,Steinbacher, Stefan

scheme or table, p. 4280 - 4283 (2010/04/30)

A series of potent Cathepsin L inhibitors with good selectivity with respect to other cysteine Cathepsins is described and SAR is discussed with reference to the crystal structure of a protein-ligand complex.

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