22179-80-2

Basic information

• Product Name: 2,4-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE
• Synonyms: 2,4-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE;2,4-DICHLOROBENZAMIDOXIME;BUTTPARK 48\11-35;2,4-Dichloro-N'-hydroxybenzamidine;2,4-dichloro-N-hydroxybenzene-1-carboxiMidaMide;2,4-Dichloro-N'-hydroxybenziMidaMide
• CAS NO: 22179-80-2
• Molecular Formula: C₇H₆Cl₂N₂O
• Molecular Weight: 205.04
• Mol File: 22179-80-2.mol
• Article Data: 16

Chemical Properties

• Melting Point: 156-158℃
• Boiling Point: 311℃
• Flash Point: 142℃
• Appearance: /
• Density: 1.52
• Vapor Pressure: 4.43E-06mmHg at 25°C
• Refractive Index: 1.622
• Storage Temp.: 2-8°C
• CAS DataBase Reference: 2,4-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(22179-80-2)
• EPA Substance Registry System: 2,4-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE(22179-80-2)

Safety Data

• Hazard Codes: Xi
• Statements: 41
• Safety Statements: 26-39
• Hazardous Substances Data: 22179-80-2(Hazardous Substances Data)

Usage

General Description

2,4-DICHLORO-N'-HYDROXYBENZENECARBOXIMIDAMIDE, also known as Dicamba, is a widely used herbicide that is effective in controlling broadleaf weeds and brush. It works by mimicking the plant growth hormone auxin, causing uncontrolled growth and ultimately leading to the death of the plant. Dicamba is commonly used in agricultural settings, including on soybeans, corn, and wheat, as well as in residential and commercial landscaping. However, its use has been controversial due to concerns about its potential to drift and damage neighboring crops, as well as its impact on human and environmental health. Efforts are being made to develop formulations and application practices that minimize these risks while still providing effective weed control.

InChI:InChI=1/C7H6Cl2N2O/c8-4-1-2-5(6(9)3-4)7(10)11-12/h1-3,12H,(H2,10,11)

Upstream product

• 6574-98-7 2,4-dichlorobenzylnitrile 
• 56843-28-8 2,4-dichlorobenzaldoxime 

Downstream Products

• 69792-97-8 3-(2,4-dichloro-phenyl)-5-ethoxy-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 
• 69792-78-5 5-methyl-3-(2,4-dichlorophenyl)-1,2,4-oxadiazole 
• 69792-79-6 1-[3-(2,4-dichloro-phenyl)-[1,2,4]oxadiazol-5-yl]-propan-2-one 
• 69792-92-3 3-(2,4-dichloro-phenyl)-5-methyl-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 
• 69792-81-0 2-[3-(2,4-dichloro-phenyl)-[1,2,4]oxadiazol-5-yl]-aniline 
• 69792-80-9 3-(2,4-dichlorophenyl)-5-(furan-2-yl)-1,2,4-oxadiazole 
• 70048-89-4 5-chloromethyl-3-(2,4-dichloro-phenyl)-2⁽⁴⁾,5-dihydro-[1,2,4]oxadiazole 

Relevant articles and documents

HETEROCYCLIC COMPOUNDS

The invention provides new heterocyclic compounds having the general formula (I) wherein A, L1, X, m, n and R1 to R4 are as described herein, compositions including the compounds, processes of manufacturing the compounds and methods of using the compounds.

KCNT1 INHIBITORS AND METHODS OF USE

The present invention is directed to, in part, compounds and compositions useful for preventing and/or treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene (e.g., KCNT1). Methods of treating a neurological disease or disorder, a disease or condition relating to excessive neuronal excitability, and/or a gain-of-function mutation in a gene such as KCNT1 are also provided herein.

A cascade process for directly converting nitriles (RCN) to cyanamides (RNHCN) via SO2F2-activated Tiemann rearrangement

A simple, mild and practical process for the direct conversion of nitriles to cyanamides was newly discovered and exhibited a wide substrate scope as well as great functional group-tolerability (36 examples). In this efficient strategy, the in situ generated amidoximes obtained from the reaction of nitriles with hydroxylamine subsequently underwent Tiemann rearrangement, producing the corresponding cyanamides with great isolated yields under SO2F2. Additionally, the control experiments reportedly shed light on the tentative mechanism involved in the formation and elimination of the key intermediate: a sulfonyl ester.