2217-41-6

Basic information

• Product Name: 5,6,7,8-Tetrahydro-1-naphthylamine
• Synonyms: 1,2,3,4-Tetrahydro-5-naphthylamine;1-Naphthylamine, 5,6,7,8-tetrahydro-;4-Amino-6-oxo-thioxo-1,2,3,6-tetrahydropyrimidine;5,6,7,8-tetrahydro-1-naphthylamin;5-Amino-1,2,3,4-tetrahydronaphthalene;5-Tetralylamine;alpha-Tetrahydronaphthylamine;5,6,7,8-TETRAHYDRO-1-NAPHTHALENAMINE
• CAS NO: 2217-41-6
• Molecular Formula: C₁₀H₁₃N
• Molecular Weight: 147.22
• EINECS: 218-713-2
• Product Categories: Amines;Building Blocks;C10;Chemical Synthesis;Nitrogen Compounds;Organic Building Blocks
• Mol File: 2217-41-6.mol
• Article Data: 16

Chemical Properties

• Melting Point: 38 °C(lit.)
• Boiling Point: 275-277 °C713 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: Clear yellow to brown/Liquid
• Density: 1,06 g/cm3
• Vapor Pressure: 0.0032mmHg at 25°C
• Refractive Index: n20/D 1.590(lit.)
• Solubility: miscible with Alcohol
• PKA: 4.56±0.20(Predicted)
• BRN: 387264
• CAS DataBase Reference: 5,6,7,8-Tetrahydro-1-naphthylamine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-Tetrahydro-1-naphthylamine(2217-41-6)
• EPA Substance Registry System: 5,6,7,8-Tetrahydro-1-naphthylamine(2217-41-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• RTECS: QM4780000
• F: 9
• Hazardous Substances Data: 2217-41-6(Hazardous Substances Data)

Usage

Description

5,6,7,8-Tetrahydro-1-naphthylamine is an organic compound with the chemical formula C10H11N. It is a clear yellow to brown liquid and is commonly utilized as a reagent in the synthesis of various compounds due to its unique chemical properties.

Uses

Used in Pharmaceutical Industry:
5,6,7,8-Tetrahydro-1-naphthylamine is used as a reagent for the synthesis of GoSlo-SR-5-69, a potent activator of large conductance Ca2+-activated K+ (BK) channels. This application is significant in the development of drugs targeting various medical conditions, as BK channel activation can have therapeutic effects on conditions such as hypertension and other cardiovascular diseases.
Used in Chemical Research:
5,6,7,8-Tetrahydro-1-naphthylamine is also used as a reagent in the synthesis of benzopyrans and related compounds. These compounds serve as inhibitors of the hypoxia-inducible factor (HIF) pathway, which plays a crucial role in cellular responses to low oxygen levels and is involved in the development of several diseases, including cancer. By inhibiting the HIF pathway, these synthesized compounds can potentially be used in the development of treatments for diseases associated with hypoxia and HIF dysregulation.

InChI:InChI=1/C10H13N/c11-10-7-3-5-8-4-1-2-6-9(8)10/h3,5,7H,1-2,4,6,11H2

Upstream product

• 32666-56-1 1-amino-5,8-dihydronaphthalene 
• 134-32-7 1-amino-naphthalene 
• 605-71-0 1,5-dinitronaphthalene 
• 29809-14-1 5-nitro-1,2,3,4-tetrahydronaphthalene 
• 64-17-5 ethanol 
• 602-38-0 1,8-dinitronaphthalene 
• 86-57-7 1-Nitronaphthalene 
• 110-82-7 cyclohexane 
• 90-15-3 α-naphthol 
• 67-56-1 methanol 
• 71-41-0 pentan-1-ol 
• 75-04-7 ethylamine 
• 78422-63-6 4-amino-5,6,7,8-tetrahydro-naphthalene-2-sulfonic acid 
• 575-36-0 1-acetamidonaphthalene 

Downstream Products

• 19356-99-1 N-(5,6,7,8-tetrahydro-[1]naphthyl)-phthalamic acid 
• 101574-48-5 N-phenyl-N'-(5,6,7,8-tetrahydro-[1]naphthyl)-urea 
• 78015-38-0 N-phenyl-N'-(5,6,7,8-tetrahydro-[1]naphthyl)-thiourea 
• 22302-73-4 1-(Chloroacetamido)-5,6,7,8-tetrahydronaphthalin 
• 138536-34-2 4-methyl-N-(5,6,7,8-tetrahydronaphthalen-1-yl)benzenesulfonamide 
• 97135-12-1 8,9,10,11-tetrahydrodibenzacridine 
• 6266-55-3 3-hydroxy-[2]naphthoic acid-(5,6,7,8-tetrahydro-[1]naphthylamide) 
• 13541-35-0 1-N,N-dimethylamino-5,6,7,8-tetrahyfronaphthalene 
• 124-04-9 Adipic acid 
• 529-35-1 5,6,7,8-Tetrahydronaphthalen-1-ol 
• 29809-13-0 5,6,7,8-tetrahydronaphthalene-1-carbonitrile 
• 6134-55-0 5-bromotetralin 
• 79506-62-0 5,6,7,8-tetrahydro-naphthalene-1-thiol 
• 76663-00-8 N-(4-Sulfamoyl-phenyl)-2-(5,6,7,8-tetrahydro-naphthalen-1-ylamino)-acetamide 

Relevant articles and documents

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Ether compound and pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome

The invention relates to an ether compound and a pharmaceutical application thereof in prevention and treatment of diabetes and metabolic syndrome. Specifically, the invention provides a compound as shown in a formula (I), an isomer, a raceme, a prodrug, a solvate, a deuterated substance or a pharmaceutically acceptable salt thereof, and Ar1, Ar2, X, Y and R are defined in the specification.

Cobalt-Nanoparticles Catalyzed Efficient and Selective Hydrogenation of Aromatic Hydrocarbons

The development of inexpensive and practical catalysts for arene hydrogenations is key for future valorizations of this general feedstock. Here, we report the development of cobalt nanoparticles supported on silica as selective and general catalysts for such reactions. The specific nanoparticles were prepared by assembling cobalt-pyromellitic acid-piperazine coordination polymer on commercial silica and subsequent pyrolysis. Applying the optimal nanocatalyst, industrial bulk, substituted, and functionalized arenes as well as polycyclic aromatic hydrocarbons are selectively hydrogenated to obtain cyclohexane-based compounds under industrially viable and scalable conditions. The applicability of this hydrogenation methodology is presented for the storage of H2 in liquid organic hydrogen carriers.

Superelectrophilic activation of 1-nitronaphthalene in the presence of aluminum chloride. Reactions with benzene and cyclohexane

1-Nitronaphthalene smoothly reacts with benzene and undergoes selective reduction with cyclohexane in the presence of aluminum chloride to give 2,4,4-triphenyl-3,4-dihydronaphthalen-1(2H)-one oxime and 5,6,7,8-tetrahydro-1-naphthylamine, respectively. The mechanistic aspects of these and related reactions are discussed on the basis of DFT, providing insight into the protonation behavior of 1-nitronaphthalene coordinated to AlCl3.