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2216-69-5

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2216-69-5 Usage

Description

1-Methoxynaphthalene is a methoxyphenolic compound and a naphthalene derivative that exhibits a range of applications in various industries. It is characterized as a clear light yellow to brown liquid with a less pleasant aroma compared to 2-methoxynaphthalene. 1-Methoxynaphthalene is insoluble in water but soluble in ethanol, ether, benzene, and chloroform.

Uses

Used in Pharmaceutical Research:
1-Methoxynaphthalene is used as a precursor for the preparation of pharmaceutical drugs, contributing to the development of new therapeutic agents.
Used in Enzyme Activity Studies:
In the field of biochemistry, 1-Methoxynaphthalene serves as a valuable tool in studying the peroxygenase activity of cytochrome c peroxidase, aiding researchers in understanding enzyme mechanisms.
Used in Organic Synthesis:
1-Methoxynaphthalene is utilized as a precursor to synthesize prenyl naphthalene-ols, which exhibit antioxidative activity and have potential applications in various chemical processes.
Used in Pesticide Industry:
As a component in the formulation of pesticides, 1-Methoxynaphthalene contributes to the development of effective pest control solutions.
Used in Perfumery:
In the perfume industry, 1-Methoxynaphthalene is used in the production of fragrances for soaps, enhancing the scent and quality of the final product.
Used in Film Development:
1-Methoxynaphthalene plays a role in the film development process, contributing to the production of high-quality photographic films.

Preparation

1-Methoxynaphthalene can be obtained by methylating 1-naphthol, and the methylating reagent can be selected from methyl trifluoroacetate, dimethyl carbonate and dimethyl sulfate.

Synthesis Reference(s)

Tetrahedron Letters, 32, p. 675, 1991 DOI: 10.1016/S0040-4039(00)74857-X

Purification Methods

Steam distil the ether from alkaline solution. The distillate is extracted with Et2O. After drying (MgSO4) the extract and evaporating Et2O, the methyl naphthyl ether is then fractionated under reduced pressure from CaH2. The picrate has m 129.5-130.5o (from EtOH). [Beilstein 6 IV 4211.]

Check Digit Verification of cas no

The CAS Registry Mumber 2216-69-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,2,1 and 6 respectively; the second part has 2 digits, 6 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 2216-69:
(6*2)+(5*2)+(4*1)+(3*6)+(2*6)+(1*9)=65
65 % 10 = 5
So 2216-69-5 is a valid CAS Registry Number.
InChI:InChI=1/C11H10O/c1-12-11-8-4-6-9-5-2-3-7-10(9)11/h2-8H,1H3

2216-69-5 Well-known Company Product Price

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  • Alfa Aesar

  • (B24825)  1-Methoxynaphthalene, 98+%   

  • 2216-69-5

  • 25g

  • 466.0CNY

  • Detail
  • Alfa Aesar

  • (B24825)  1-Methoxynaphthalene, 98+%   

  • 2216-69-5

  • 100g

  • 953.0CNY

  • Detail
  • Alfa Aesar

  • (B24825)  1-Methoxynaphthalene, 98+%   

  • 2216-69-5

  • 500g

  • 4058.0CNY

  • Detail

2216-69-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 11, 2017

Revision Date: Aug 11, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-Methoxynaphthalene

1.2 Other means of identification

Product number -
Other names Naphthalene, 1-methoxy-

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only. Food additives -> Flavoring Agents
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2216-69-5 SDS

2216-69-5Relevant articles and documents

Heterocyclic seven-membered ring compounds, XXVIII. On 5-acetoxy- and 5-methoxy-1-benzothiepine and analogous 1-benzoxepines

Hofmann,Djafari

, p. 599 - 604 (1985)

-

-

Fischer et al.

, p. 106 (1966)

-

A Mild Heteroatom (O -, N -, and S -) Methylation Protocol Using Trimethyl Phosphate (TMP)-Ca(OH) 2Combination

Tang, Yu,Yu, Biao

, (2022/03/27)

A mild heteroatom methylation protocol using trimethyl phosphate (TMP)-Ca(OH)2combination has been developed, which proceeds in DMF, or water, or under neat conditions, at 80 °C or at room temperature. A series of O-, N-, and S-nucleophiles, including phenols, sulfonamides, N-heterocycles, such as 9H-carbazole, indole derivatives, and 1,8-naphthalimide, and aryl/alkyl thiols, are suitable substrates for this protocol. The high efficiency, operational simplicity, scalability, cost-efficiency, and environmentally friendly nature of this protocol make it an attractive alternative to the conventional base-promoted heteroatom methylation procedures.

Preparation method of naphthalene ring C marked α .

-

Paragraph 0046-0048; 0056-0058; 0066-0068, (2021/10/05)

The invention discloses C labeled α - naphthalene acetic acid preparation method and belongs to the field of radioisotope C labeled compounds. C-labeled α - naphthylacetic acid preparation method, C radioisotope labeling is introduced on a naphthalene ring structure α -naphthol acid, C labeling site is in α-position. The method has the advantages that the reaction raw materials are easily available, the synthesis steps are high in yield, the total yield is more 60%, C marker isotopes are less in use amount, and waste is generated. The marker site α-position on the naphthalene ring is less likely to be metabolized compared to C-labeled branched acetic acid, and the synthesized C-labeled compound provides a better study of α -naphthoic acid in the environment.

A highly stable all-in-one photocatalyst for aryl etherification: The NiIIembedded covalent organic framework

Chen, Hao,Dong, Wenbo,Hu, Jianxiang,Rao, Li,Wang, Pei,Wang, Shengyao,Xiang, Yonggang,Yang, Yi

, p. 5797 - 5805 (2021/08/23)

The efficient conversion of aryl bromides to the corresponding aryl alkyl ethers by dual nickel/photocatalysis has seen great progress, but difficulties of recycling the photosensitizer or nickel complexes cause problems of sustainability. Here, we report the design of a novel, highly stable vinyl bridge 2D covalent organic framework (COF) containing Ni, which combines the role of photosensitizer and reactive site. The as-prepared sp2c-COFdpy-Ni acts as an efficient heterogeneous photocatalyst for C-O cross coupling. The sp2c-COFdpy-Ni can be completely recovered and used repeatedly without loss of activity, overcoming the limitations of the prior methods. Preliminary studies reveal that strong interlayer electron transfer may facilitate the generation of the proposed intermediate sp2c-COFdpy-NiI in a bimolecular and self-sustained manner. This all-in-one heterogeneous photocatalyst exhibits good compatibility of substrates and tolerance of functional groups. The successful attempt to expand the 2D COFs with this new catalyst into photocatalytic organic transformation opens an avenue for photoredox/transition metal mediated coupling reactions.

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