21987-29-1

Basic information

• Product Name: 4,4-DIFLUOROPIPERIDINE
• Synonyms: 4,4-DIFLUOROPIPERIDINE;Piperidine, 4,4-difluoro-
• CAS NO: 21987-29-1
• Molecular Formula: C₅H₉F₂N
• Molecular Weight: 121.13
• Product Categories: pharmacetical;Pharmaceutical intermediate
• Mol File: 21987-29-1.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 34°C 12mm
• Flash Point: 22.931 °C
• Appearance: /
• Density: 1.089 g/cm³
• Vapor Pressure: 20mmHg at 25°C
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• Solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
• PKA: 8.20±0.10(Predicted)
• CAS DataBase Reference: 4,4-DIFLUOROPIPERIDINE(CAS DataBase Reference)
• NIST Chemistry Reference: 4,4-DIFLUOROPIPERIDINE(21987-29-1)
• EPA Substance Registry System: 4,4-DIFLUOROPIPERIDINE(21987-29-1)

Safety Data

• Statements: 36/37/38
• Safety Statements: 16-26-36/37/39
• Hazardous Substances Data: 21987-29-1(Hazardous Substances Data)

Usage

Description

4,4-Difluoropiperidine is an organic compound with the molecular formula C5H10F2N. It is primarily known for its usage in pharmaceutical and medical research. 4,4-DIFLUOROPIPERIDINE exists as a clear or slightly yellow liquid and is classified as an organic compound with piperidines as its main functional group, which largely contributes to its properties and characteristics. Although there is limited information about its impact on human health, it is considered potentially harmful if inhaled, ingested, or comes into contact with skin and eyes. Therefore, it is essential for researchers and anyone handling the substance to follow safety guidelines and use necessary protective equipment.

Uses

Used in Pharmaceutical Industry:
4,4-Difluoropiperidine is used as a chemical intermediate for the synthesis of various pharmaceutical compounds. Its unique structure and properties make it a valuable building block in the development of new drugs and medications.
Used in Medical Research:
4,4-Difluoropiperidine is used as a research tool in the field of medical research. It aids scientists in understanding the mechanisms of action and potential applications of various compounds, contributing to the advancement of medical knowledge and the discovery of new treatments.
Used in Chemical Synthesis:
4,4-Difluoropiperidine is used as a reagent in the synthesis of other chemical compounds. Its versatility and unique properties make it a valuable component in the creation of new materials and substances with potential applications in various industries.

InChI:InChI=1/C5H9F2N/c6-5(7)1-3-8-4-2-5/h8H,1-4H2/p+1

Upstream product

• 144230-52-4 4,4-difluoropiperidine hydrochloride 
• 79099-07-3 N-tert-butyloxycarbonylpiperidin-4-one 
• 281652-10-6 4,4-difluoropiperidine-1-formic acid tert-butyl ester 
• 39742-60-4 1-(2-phenylethyl)-4-piperidinone 
• 3612-20-2 1-phenylmethyl-4-piperidone 
• 155137-18-1 1-benzyl-4,4-difluoropiperidine 

Downstream Products

• 860344-90-7 4,4-difluoropiperidine-1-carbothioamide 
• 1394938-42-1 N-{3-[2-(4,4-difluoropiperidin-1-yl)-5-(pyridin-4-yl)-1,3-thiazol-4-yl]-2-fluorophenyl}-2,5-difluorobenzenesulfonamide 
• 1206162-31-3 cyclopropanecarboxylic acid {5-[4-(4,4-difluoro-piperidin-1-ylmethyl)-phenyl]-[1,2,4]triazolo[1,5-a]pyridin-2-yl}-amide 
• 1361323-63-8 C₃₄H₃₀F₂N₄O₂S 
• 1602923-09-0 (4-chlorophenyl)-carbamic acid (S)-1-(4,4-difluoropiperidin-1-ylmethyl)-2,2,2-trifluoroethyl ester hydrochloride 
• 1603165-05-4 (4-chlorophenyl)-carbamic acid (S)-1-(4,4-difluoropiperidin-1-ylmethyl)-2,2,2-trifluoroethyl ester 
• 1595285-95-2 (E)-N-(4-((3-chloro-4-fluorophenyl)amino)thieno[2,3-d]pyrimidin-6-yl)-4-(4,4-difluoropiperidin-1-yl)but-2-enamide 

Relevant articles and documents

Synthesis method of 4,4-difluoropiperidine-1-formyl chloride

The invention discloses a synthesis method of 4,4-difluoropiperidine-1-formyl chloride. The synthesis method comprises the following steps that first, a compound I, namely benzylpiperidin-4-one, and afluorine reagent are deoxidized and fluorated in a firs

QUINOLINE OR ISOQUINOLINE SUBSTITUTED P2X7 ANTAGONISTS

The present invention is related to novel compounds of formula (I) having P2X7 antagonistic properties, pharmaceutical compositions comprising these compounds, chemical processes for preparing these compounds and their use in the treatment or prophylaxis of diseases associated with P2X7 receptor activity in animals, in particular humans. (I)

Reduction of CYP450 inhibition in the 4-[(1H-imidazol-4-yl)methyl] piperidine series of histamine H3 receptor antagonists

A novel series of histamine H3 receptor antagonists based on the 4-[(1H-imidazol-4-yl)methyl]piperidine template displaying low CYP2D6 and CYP3A4 inhibitory profiles has been identified. Structural features responsible for the reduction of P450 activity, a typical liability of 4-substituted imidazoles, have been established.