21901-29-1

Basic information

• Product Name: 2-Amino-3-nitro-6-picoline
• Synonyms: 2-AMINO-6-METHYL-3-NITROPYRIDINE;2-AMINO-3-NITRO-6-METHYLPYRIDINE;2-AMINO-3-NITRO-6-PICOLINE;6-METHYL-3-NITRO-PYRIDIN-2-YLAMINE;6-AMINO-5-NITRO-2-PICOLINE;2-Amino-6-methyl-3-nitropyridine 95%;6-AMINO-5-NITRO-2-PICOLINE,98%;2-Amino-3-nitro-6-methylpyridine ,98%
• CAS NO: 21901-29-1
• Molecular Formula: C₆H₇N₃O₂
• Molecular Weight: 153.14
• Product Categories: compounds of pyridine;Amines;blocks;NitroCompounds;Pyridines;Pyridine;Pyridines derivates;Boronic Acid
• Mol File: 21901-29-1.mol
• Article Data: 15

Chemical Properties

• Melting Point: 147-157 °C
• Boiling Point: 276.04°C (rough estimate)
• Flash Point: 140.7 °C
• Appearance: Yellow/Crystalline Powder
• Density: 1.3682 (rough estimate)
• Vapor Pressure: 0.000655mmHg at 25°C
• Refractive Index: 1.6500 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 2.50±0.50(Predicted)
• Water Solubility: Slightly soluble in water.
• CAS DataBase Reference: 2-Amino-3-nitro-6-picoline(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Amino-3-nitro-6-picoline(21901-29-1)
• EPA Substance Registry System: 2-Amino-3-nitro-6-picoline(21901-29-1)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 36/37/38-20/21/22
• Safety Statements: 36/37/39-26-22-36
• WGK Germany: 3
• Hazardous Substances Data: 21901-29-1(Hazardous Substances Data)

Usage

Description

2-Amino-3-nitro-6-picoline, also known as 2-Amino-6-methyl-3-nitropyridine, is a yellow crystalline powder with unique chemical properties. It is an organic compound that serves as a versatile intermediate in various chemical reactions and holds potential applications in the pharmaceutical industry due to its distinct molecular structure.

Uses

Used in Organic Synthesis:
2-Amino-3-nitro-6-picoline is used as an intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows it to participate in a range of reactions, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, 2-Amino-3-nitro-6-picoline is used as a building block for the development of new drugs. Its chemical properties and reactivity enable the creation of novel drug candidates with potential therapeutic applications.
Used in Chemical Research:
2-Amino-3-nitro-6-picoline is also utilized in chemical research to study the properties and behavior of various organic compounds. Its unique structure provides researchers with valuable insights into the mechanisms of chemical reactions and the development of new synthetic methods.

InChI:InChI=1/C6H7N3O2/c1-4-2-3-5(9(10)11)6(7)8-4/h2-3H,1H3,(H2,7,8)/p+1

Upstream product

• 1824-81-3 2-Amino-6-methylpyridine 
• 19346-45-3 2-fluoro-3-nitro-6-methylpyridine 
• 109-06-8 α-picoline 
• 33986-37-7 6-methyl-2-nitraminopyridine 
• 7664-93-9 sulfuric acid 
• 2802-08-6 (E)-4-(dimethylamino)but-3-en-2-one 
• 71090-35-2 1,1-diamino-2-nitroethene 
• 2802-09-7 cis-1-amino-1-buten-3-one 
• 92277-16-2 Nitroacetamidsaeuremethylester-hydrochlorid 

Downstream Products

• 33259-72-2 2,3-diamino-6-methyl-pyridine 
• 39745-39-6 6-methyl-3-nitrohydropyridin-2-one 
• 56057-19-3 2-chloro-6-methyl-3-nitropyridine 
• 939053-51-7 N-(6-methyl-3-nitropyridin-2-yl)benzamide 
• 39745-39-6 6-methyl-3-nitropyridin-2-one 
• 52334-80-2 3-benzoylamino-6-methyl-2-pyridone 
• 112163-03-8 5-nitro-6-methoxy-2-methylpyridine 

Relevant articles and documents

Fragment-Based Drug Discovery of Inhibitors of Phosphopantetheine Adenylyltransferase from Gram-Negative Bacteria

The discovery and development of new antibiotics capable of curing infections due to multidrug-resistant and pandrug-resistant Gram-negative bacteria are a major challenge with fundamental importance to our global healthcare system. Part of our broad program at Novartis to address this urgent, unmet need includes the search for new agents that inhibit novel bacterial targets. Here we report the discovery and hit-to-lead optimization of new inhibitors of phosphopantetheine adenylyltransferase (PPAT) from Gram-negative bacteria. Utilizing a fragment-based screening approach, we discovered a number of unique scaffolds capable of interacting with the pantetheine site of E. coli PPAT and inhibiting enzymatic activity, including triazolopyrimidinone 6. Structure-based optimization resulted in the identification of two lead compounds as selective, small molecule inhibitors of bacterial PPAT: triazolopyrimidinone 53 and azabenzimidazole 54 efficiently inhibited E. coli and P. aeruginosa PPAT and displayed modest cellular potency against the efflux-deficient E. coli ΔtolC mutant strain.

THE NITROPYRIDINYL ETHYLENEIMINE COMPOUND, THE PHARMACEUTICAL COMPOSITION CONTAINING IT, THE PREPARATION METHOD AND USE THEREOF

The present invention discloses a nitropyridinyl ethyleneimine compound as shown in the formula I and a preparation method of the same, as well as use of the compound in manufacture of a prodrug and in manufacture of a drug for treating a tumor.

Discovery of heterobicyclic templates for novel metabotropic glutamate receptor subtype 5 antagonists

Investigation of a series of heterobicyclic compounds with essential pharmacophoric features of the metabotropic glutamate receptor 5 (mGluR5) antagonists MPEP and MTEP provided novel structural templates with sub-micromolar affinities at the mGluR5.