21733-03-9

Basic information

• Product Name: 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID
• Synonyms: 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID;5-Chloro-1H-1,2,4-triazole-3-carboxylic acid N-methylmethanamine;5-Chloro-2H-1,2,4-triazole-3-carboxylic acid
• CAS NO: 21733-03-9
• Molecular Formula: C3H2ClN3O2
• Molecular Weight: 147.52
• Mol File: 21733-03-9.mol
• Article Data: 1

Chemical Properties

• Boiling Point: 483.7 °C at 760 mmHg
• Flash Point: 246.4 °C
• Appearance: /
• Density: 1.874 g/cm³
• PKA: 2.92±0.10(Predicted)
• CAS DataBase Reference: 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID(21733-03-9)
• EPA Substance Registry System: 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID(21733-03-9)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 21733-03-9(Hazardous Substances Data)

Usage

Description

5-Chloro-1H-1,2,4-triazole-3-carboxylic acid is a chemical compound belonging to the triazole family, characterized by the molecular formula C3H2ClN3O2. It features a carboxylic acid group and is recognized for its role as a versatile building block in organic synthesis and pharmaceutical chemistry, enabling the creation of a variety of chemical compounds with tailored properties.

Uses

Used in Organic Synthesis:
5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID serves as a key intermediate in organic synthesis, facilitating the production of a range of chemical compounds with specific applications across different industries.
Used in Pharmaceutical Chemistry:
In the pharmaceutical industry, 5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID is utilized as an intermediate for the synthesis of various pharmaceuticals, contributing to the development of new drugs with potential therapeutic benefits.
Used in Agrochemical Production:
5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID is employed as a building block in the creation of agrochemicals, playing a crucial role in the development of products designed to enhance crop protection and yield.
Used in Specialty Chemicals:
5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID also finds application in the production of specialty chemicals, where its unique properties allow for the creation of compounds used in specific applications, such as coatings, adhesives, or materials with particular performance characteristics.
Used in Research and Development:
5-CHLORO-1H-1,2,4-TRIAZOLE-3-CARBOXYLIC ACID is further utilized in research and development settings to explore its potential pharmacological and biological activities, with the aim of discovering new uses and expanding its applications in various fields.

Upstream product

• 3641-13-2 5-amino-1H-[1,2,4]triazole-3-carboxylic acid 

Downstream Products

• 21733-05-1 methyl 5-chloro-1,2,4-triazole-3-carboxylate 

Relevant articles and documents

Chemoenzymatic method of 1,2,4-triazole nucleoside synthesis: Possibilities and limitations

Possibilities and limitations of chemoenzymatic synthesis of novel structural analogues of an antiviral preparation of Ribavirin (1-β-D-ribofuranosyl-1,2,4-triazole-3-carboxamide) were established. A synthesis of various amides of 1H-1,2,4-triazole-3-carboxylic acid and its 5-substituted analogues - potential substrates of purine nucleoside phosphorylase - has been described. Comparative efficiency of preparation methods of these amides, as well as the methods of introduction of functional groups to the C5 position of heterocyclic system, were investigated. Novel analogues of Ribavirin containing various substitutes in the carboxamide group were synthesized. A biotechnological method was developed for the preparation of 1-β-D-ribofuranozyl-1,2,4-triazole-3-carbonitryl, an intermediate in the synthesis of Viramidine, the modern analogue of Ribavirin.